Alginate–Chitosan Membranes for the Encapsulation of Lavender Essential Oil and Development of Biomedical Applications Related to Wound Healing

Detalhes bibliográficos
Autor(a) principal: Cruz Sánchez, Encarnación
Data de Publicação: 2023
Outros Autores: García, María Teresa, Pereira, Joana, Oliveira, Filipe, Craveiro, Rita, Paiva, Alexandre, Gracia, Ignacio, García-Vargas, Jesús Manuel, Duarte, Ana Rita C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/154628
Resumo: This research was funded by the project Ref. SBPLY/17/180501/000311 from the Consejería de Educación, Cultura y Deportes of Junta de Comunidades de Castilla-La Mancha. It has also been possible to carry out this work thanks to funding from the “Call for grants to carry out pre-doctoral stays in foreign Universities and Research Centres for UCLM doctoral students—Co-funded by the Collaboration Agreement between the University of Castilla-La Mancha and Banco Santander”. Publisher Copyright: © 2023 by the authors.
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spelling Alginate–Chitosan Membranes for the Encapsulation of Lavender Essential Oil and Development of Biomedical Applications Related to Wound Healingalginatebiocompatibility assessmentcell viabilitychitosanlavender essential oilmembraneswater uptake abilitywound healingAnalytical ChemistryChemistry (miscellaneous)Molecular MedicinePharmaceutical ScienceDrug DiscoveryPhysical and Theoretical ChemistryOrganic ChemistryThis research was funded by the project Ref. SBPLY/17/180501/000311 from the Consejería de Educación, Cultura y Deportes of Junta de Comunidades de Castilla-La Mancha. It has also been possible to carry out this work thanks to funding from the “Call for grants to carry out pre-doctoral stays in foreign Universities and Research Centres for UCLM doctoral students—Co-funded by the Collaboration Agreement between the University of Castilla-La Mancha and Banco Santander”. Publisher Copyright: © 2023 by the authors.Biopolymers such as chitosan (CHT) or alginate (ALG) are among the most prominent for health-related applications due to their broad bioactivity. Their combination for the preparation of membranes is hereby proposed as an application for wound healing with the incorporation of lavender essential oil (LEO), widely known for its antioxidant and antimicrobial properties. The preparation of CHT, CHT + LEO, ALG, ALG + LEO, and CHT/ALG + LEO membranes was accomplished, and its composition was analyzed using Fourier Transform Infrared Spectroscopy (FTIR). The water absorption capacity and oil release profile of the membranes revealed higher water uptake capacity when a lower LEO release was obtained. The combined CHT/ALG + LEO film showed a water uptake percentage of 638% after 48 h and a maximum LEO release concentration of 42 mg/L. Cytotoxicity and biocompatibility of the prepared membranes were studied using a HaCaT cell line, with an assessment of cell viability regarding film leachables, DNA quantification, and DAPI-phalloidin staining. The results revealed that the indirect contact of the prepared membranes via its leachables does not compromise cell viability, and upon direct contact, cells do not adhere or proliferate on the surface of the membranes. Moreover, the CHT/ALG + LEO membrane increases cell proliferation, making it suitable for applications in wound healing.LAQV@REQUIMTEDQ - Departamento de QuímicaRUNCruz Sánchez, EncarnaciónGarcía, María TeresaPereira, JoanaOliveira, FilipeCraveiro, RitaPaiva, AlexandreGracia, IgnacioGarcía-Vargas, Jesús ManuelDuarte, Ana Rita C.2023-06-29T22:17:54Z2023-04-252023-04-25T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article14application/pdfhttp://hdl.handle.net/10362/154628eng1420-3049PURE: 64823050https://doi.org/10.3390/molecules28093689info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:37:07Zoai:run.unl.pt:10362/154628Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:55:42.499334Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Alginate–Chitosan Membranes for the Encapsulation of Lavender Essential Oil and Development of Biomedical Applications Related to Wound Healing
title Alginate–Chitosan Membranes for the Encapsulation of Lavender Essential Oil and Development of Biomedical Applications Related to Wound Healing
spellingShingle Alginate–Chitosan Membranes for the Encapsulation of Lavender Essential Oil and Development of Biomedical Applications Related to Wound Healing
Cruz Sánchez, Encarnación
alginate
biocompatibility assessment
cell viability
chitosan
lavender essential oil
membranes
water uptake ability
wound healing
Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry
title_short Alginate–Chitosan Membranes for the Encapsulation of Lavender Essential Oil and Development of Biomedical Applications Related to Wound Healing
title_full Alginate–Chitosan Membranes for the Encapsulation of Lavender Essential Oil and Development of Biomedical Applications Related to Wound Healing
title_fullStr Alginate–Chitosan Membranes for the Encapsulation of Lavender Essential Oil and Development of Biomedical Applications Related to Wound Healing
title_full_unstemmed Alginate–Chitosan Membranes for the Encapsulation of Lavender Essential Oil and Development of Biomedical Applications Related to Wound Healing
title_sort Alginate–Chitosan Membranes for the Encapsulation of Lavender Essential Oil and Development of Biomedical Applications Related to Wound Healing
author Cruz Sánchez, Encarnación
author_facet Cruz Sánchez, Encarnación
García, María Teresa
Pereira, Joana
Oliveira, Filipe
Craveiro, Rita
Paiva, Alexandre
Gracia, Ignacio
García-Vargas, Jesús Manuel
Duarte, Ana Rita C.
author_role author
author2 García, María Teresa
Pereira, Joana
Oliveira, Filipe
Craveiro, Rita
Paiva, Alexandre
Gracia, Ignacio
García-Vargas, Jesús Manuel
Duarte, Ana Rita C.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv LAQV@REQUIMTE
DQ - Departamento de Química
RUN
dc.contributor.author.fl_str_mv Cruz Sánchez, Encarnación
García, María Teresa
Pereira, Joana
Oliveira, Filipe
Craveiro, Rita
Paiva, Alexandre
Gracia, Ignacio
García-Vargas, Jesús Manuel
Duarte, Ana Rita C.
dc.subject.por.fl_str_mv alginate
biocompatibility assessment
cell viability
chitosan
lavender essential oil
membranes
water uptake ability
wound healing
Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry
topic alginate
biocompatibility assessment
cell viability
chitosan
lavender essential oil
membranes
water uptake ability
wound healing
Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry
description This research was funded by the project Ref. SBPLY/17/180501/000311 from the Consejería de Educación, Cultura y Deportes of Junta de Comunidades de Castilla-La Mancha. It has also been possible to carry out this work thanks to funding from the “Call for grants to carry out pre-doctoral stays in foreign Universities and Research Centres for UCLM doctoral students—Co-funded by the Collaboration Agreement between the University of Castilla-La Mancha and Banco Santander”. Publisher Copyright: © 2023 by the authors.
publishDate 2023
dc.date.none.fl_str_mv 2023-06-29T22:17:54Z
2023-04-25
2023-04-25T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/154628
url http://hdl.handle.net/10362/154628
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1420-3049
PURE: 64823050
https://doi.org/10.3390/molecules28093689
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 14
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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