Metabolic profiling and combined therapeutic strategies unveil the cytotoxic potential of selenium-chrysin (SeChry) in NSCLC cells

Detalhes bibliográficos
Autor(a) principal: Mendes, Cindy
Data de Publicação: 2024
Outros Autores: Lemos, Isabel, Hipólito, Ana, Abreu, Bruna, Freitas-Dias, Catarina, Martins, Filipa, Pires, Rita F., Barros, Hélio, Bonifácio, Vasco D.B., Gonçalves, Luís G., Serpa, Jacinta
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/172774
Resumo: Funding Information: The institutions are funded by Fundac\u00B8 \u00E3o para a Ci\u00EAncia e a Tecnologia/Minist\u00E9rio da Ci\u00EAncia, Tecnologia e Ensino Superior (FCT/MCTES, Portugal) through national funds to iNO-VA4Health [grant numbers UIDB/04462/2020 and UIDP/04462/2020], to MOSTMICRO-ITQB [grant numbers UIDB/04612/2020 and UIDP/04612/2020] and the Associated Laboratory LS4FUTURE [grant number LA/P/0087/2020]. During the course of PhD, Cindy Mendes was funded by Liga Portuguesa Contra o Cancro -Nucleo regional Sul (LPCC-NRS) and by an FCT individual Ph.D. fellowship [grant number 2020.06956.BD]. Isabel Lemos was funded by an FCT individual Ph.D. fellowship [grant number UI/BD/154203/2022]. Ana Hip\u00F3lito was funded by a FCT individual Ph.D. fellowship [grant number SFRH/BD/148441/2019]. Filipa Martins was funded by a FCT individual Ph.D. fellowship (2020.04780.BD). Luis G. Gonc\u00B8 alves was financed by a FCT contract according to DL57/2016, [grant number SFRH/BPD/111100/2015]. This work benefited from access to CERMAX, ITQB-NOVA, Oeiras, Portugal with equipment funded by FCT, project AAC 01/SAICT/2016. Publisher Copyright: © 2024 The Author(s).
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spelling Metabolic profiling and combined therapeutic strategies unveil the cytotoxic potential of selenium-chrysin (SeChry) in NSCLC cellsBiophysicsBiochemistryMolecular BiologyCell BiologySDG 3 - Good Health and Well-beingFunding Information: The institutions are funded by Fundac\u00B8 \u00E3o para a Ci\u00EAncia e a Tecnologia/Minist\u00E9rio da Ci\u00EAncia, Tecnologia e Ensino Superior (FCT/MCTES, Portugal) through national funds to iNO-VA4Health [grant numbers UIDB/04462/2020 and UIDP/04462/2020], to MOSTMICRO-ITQB [grant numbers UIDB/04612/2020 and UIDP/04612/2020] and the Associated Laboratory LS4FUTURE [grant number LA/P/0087/2020]. During the course of PhD, Cindy Mendes was funded by Liga Portuguesa Contra o Cancro -Nucleo regional Sul (LPCC-NRS) and by an FCT individual Ph.D. fellowship [grant number 2020.06956.BD]. Isabel Lemos was funded by an FCT individual Ph.D. fellowship [grant number UI/BD/154203/2022]. Ana Hip\u00F3lito was funded by a FCT individual Ph.D. fellowship [grant number SFRH/BD/148441/2019]. Filipa Martins was funded by a FCT individual Ph.D. fellowship (2020.04780.BD). Luis G. Gonc\u00B8 alves was financed by a FCT contract according to DL57/2016, [grant number SFRH/BPD/111100/2015]. This work benefited from access to CERMAX, ITQB-NOVA, Oeiras, Portugal with equipment funded by FCT, project AAC 01/SAICT/2016. Publisher Copyright: © 2024 The Author(s).Lung cancer ranks as the predominant cause of cancer-related mortalities on a global scale. Despite progress in therapeutic interventions, encompassing surgical procedures, radiation, chemotherapy, targeted therapies and immunotherapy, the overall prognosis remains unfavorable. Imbalances in redox equilibrium and disrupted redox signaling, common traits in tumors, play crucial roles in malignant progression and treatment resistance. Cancer cells, often characterized by persistent high levels of reactive oxygen species (ROS) resulting from genetic, metabolic, and microenvironmental alterations, counterbalance this by enhancing their antioxidant capacity. Cysteine availability emerges as a critical factor in chemoresistance, shaping the survival dynamics of non-small cell lung cancer (NSCLC) cells. Selenium-chrysin (SeChry) was disclosed as a modulator of cysteine intracellular availability. This study comprehensively characterizes the metabolism of SeChry and investigates its cytotoxic effects in NSCLC. SeChry treatment induces notable metabolic shifts, particularly in selenocompound metabolism, impacting crucial pathways such as glycolysis, gluconeogenesis, the tricarboxylic acid (TCA) cycle, and amino acid metabolism. Additionally, SeChry affects the levels of key metabolites such as acetate, lactate, glucose, and amino acids, contributing to disruptions in redox homeostasis and cellular biosynthesis. The combination of SeChry with other treatments, such as glycolysis inhibition and chemotherapy, results in greater efficacy. Furthermore, by exploiting NSCLC’s capacity to consume lactate, the use of lactic acid-conjugated dendrimer nanoparticles for SeChry delivery is investigated, showing specificity to cancer cells expressing monocarboxylate transporters.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)iNOVA4Health - pólo NMSInstituto de Tecnologia Química e Biológica António Xavier (ITQB)RUNMendes, CindyLemos, IsabelHipólito, AnaAbreu, BrunaFreitas-Dias, CatarinaMartins, FilipaPires, Rita F.Barros, HélioBonifácio, Vasco D.B.Gonçalves, Luís G.Serpa, Jacinta2024-09-30T22:35:00Z2024-07-012024-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/172774eng0144-8463PURE: 100330555https://doi.org/10.1042/BSR20240752info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-11T01:38:47Zoai:run.unl.pt:10362/172774Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-11T01:38:47Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Metabolic profiling and combined therapeutic strategies unveil the cytotoxic potential of selenium-chrysin (SeChry) in NSCLC cells
title Metabolic profiling and combined therapeutic strategies unveil the cytotoxic potential of selenium-chrysin (SeChry) in NSCLC cells
spellingShingle Metabolic profiling and combined therapeutic strategies unveil the cytotoxic potential of selenium-chrysin (SeChry) in NSCLC cells
Mendes, Cindy
Biophysics
Biochemistry
Molecular Biology
Cell Biology
SDG 3 - Good Health and Well-being
title_short Metabolic profiling and combined therapeutic strategies unveil the cytotoxic potential of selenium-chrysin (SeChry) in NSCLC cells
title_full Metabolic profiling and combined therapeutic strategies unveil the cytotoxic potential of selenium-chrysin (SeChry) in NSCLC cells
title_fullStr Metabolic profiling and combined therapeutic strategies unveil the cytotoxic potential of selenium-chrysin (SeChry) in NSCLC cells
title_full_unstemmed Metabolic profiling and combined therapeutic strategies unveil the cytotoxic potential of selenium-chrysin (SeChry) in NSCLC cells
title_sort Metabolic profiling and combined therapeutic strategies unveil the cytotoxic potential of selenium-chrysin (SeChry) in NSCLC cells
author Mendes, Cindy
author_facet Mendes, Cindy
Lemos, Isabel
Hipólito, Ana
Abreu, Bruna
Freitas-Dias, Catarina
Martins, Filipa
Pires, Rita F.
Barros, Hélio
Bonifácio, Vasco D.B.
Gonçalves, Luís G.
Serpa, Jacinta
author_role author
author2 Lemos, Isabel
Hipólito, Ana
Abreu, Bruna
Freitas-Dias, Catarina
Martins, Filipa
Pires, Rita F.
Barros, Hélio
Bonifácio, Vasco D.B.
Gonçalves, Luís G.
Serpa, Jacinta
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
iNOVA4Health - pólo NMS
Instituto de Tecnologia Química e Biológica António Xavier (ITQB)
RUN
dc.contributor.author.fl_str_mv Mendes, Cindy
Lemos, Isabel
Hipólito, Ana
Abreu, Bruna
Freitas-Dias, Catarina
Martins, Filipa
Pires, Rita F.
Barros, Hélio
Bonifácio, Vasco D.B.
Gonçalves, Luís G.
Serpa, Jacinta
dc.subject.por.fl_str_mv Biophysics
Biochemistry
Molecular Biology
Cell Biology
SDG 3 - Good Health and Well-being
topic Biophysics
Biochemistry
Molecular Biology
Cell Biology
SDG 3 - Good Health and Well-being
description Funding Information: The institutions are funded by Fundac\u00B8 \u00E3o para a Ci\u00EAncia e a Tecnologia/Minist\u00E9rio da Ci\u00EAncia, Tecnologia e Ensino Superior (FCT/MCTES, Portugal) through national funds to iNO-VA4Health [grant numbers UIDB/04462/2020 and UIDP/04462/2020], to MOSTMICRO-ITQB [grant numbers UIDB/04612/2020 and UIDP/04612/2020] and the Associated Laboratory LS4FUTURE [grant number LA/P/0087/2020]. During the course of PhD, Cindy Mendes was funded by Liga Portuguesa Contra o Cancro -Nucleo regional Sul (LPCC-NRS) and by an FCT individual Ph.D. fellowship [grant number 2020.06956.BD]. Isabel Lemos was funded by an FCT individual Ph.D. fellowship [grant number UI/BD/154203/2022]. Ana Hip\u00F3lito was funded by a FCT individual Ph.D. fellowship [grant number SFRH/BD/148441/2019]. Filipa Martins was funded by a FCT individual Ph.D. fellowship (2020.04780.BD). Luis G. Gonc\u00B8 alves was financed by a FCT contract according to DL57/2016, [grant number SFRH/BPD/111100/2015]. This work benefited from access to CERMAX, ITQB-NOVA, Oeiras, Portugal with equipment funded by FCT, project AAC 01/SAICT/2016. Publisher Copyright: © 2024 The Author(s).
publishDate 2024
dc.date.none.fl_str_mv 2024-09-30T22:35:00Z
2024-07-01
2024-07-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/172774
url http://hdl.handle.net/10362/172774
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0144-8463
PURE: 100330555
https://doi.org/10.1042/BSR20240752
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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