Remdesivir and corticosteroids in the treatment of hospitalized COVID-19 patients

Detalhes bibliográficos
Autor(a) principal: Coelho, Luís
Data de Publicação: 2023
Outros Autores: Falcão, Fatima, Povoa, Pedro, Viegas, Erica, Martins, Antonio Pais, Carmo, Eduarda, Fonseca, Candida, Campos, Luis, Mansinho, Kamal, Carmo, Inês, Soares, Joana, Solano, Mariana, Mendes, Dina, Miranda, Ana Cláudia, Carvalho, Antonio, Mirco, Ana, Farinha, Helena, Aldir, Isabel, Correia, José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/151476
Resumo: ok
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spelling Remdesivir and corticosteroids in the treatment of hospitalized COVID-19 patientsGeneralokCoronavirus disease 2019 (COVID-19) is a pandemic infection caused by the newly discovered severe acute respiratory syndrome coronavirus 2. Remdesivir (RDV) and corticosteroids are used mainly in COVID-19 patients with acute respiratory failure. The main objective of the study was to assess the effectiveness of remdesivir with and without corticosteroids in the treatment of COVID-19 patients. We conducted a prospective observational study, including adult patients consecutively hospitalized with confirmed COVID-19 and acute respiratory failure. Patients were divided according to treatment strategy: RDV alone versus RDV with corticosteroids. The primary outcome was the time to recovery in both treatment groups. We included 374 COVID-19 adult patients, 184 were treated with RDV, and 190 were treated with RDV and corticosteroid. Patients in the RDV group had a shorter time to recovery in comparison with patients in the RDV plus corticosteroids group at 28 days after admission [11 vs. 16 days (95% confidence Interval 9.7-12.8; 14.9-17.1; p = .016)]. Patients treated with RDV alone had a shorter length of hospital stay. The use of corticosteroids as adjunctive therapy of RDV was not associated with improvement in mortality of COVID-19 patients.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNCoelho, LuísFalcão, FatimaPovoa, PedroViegas, EricaMartins, Antonio PaisCarmo, EduardaFonseca, CandidaCampos, LuisMansinho, KamalCarmo, InêsSoares, JoanaSolano, MarianaMendes, DinaMiranda, Ana CláudiaCarvalho, AntonioMirco, AnaFarinha, HelenaAldir, IsabelCorreia, José2023-03-31T22:20:53Z2023-03-182023-03-18T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1application/pdfhttp://hdl.handle.net/10362/151476eng2045-2322PURE: 57370604https://doi.org/10.1038/s41598-023-31544-5info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:33:56Zoai:run.unl.pt:10362/151476Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:54:36.812560Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Remdesivir and corticosteroids in the treatment of hospitalized COVID-19 patients
title Remdesivir and corticosteroids in the treatment of hospitalized COVID-19 patients
spellingShingle Remdesivir and corticosteroids in the treatment of hospitalized COVID-19 patients
Coelho, Luís
General
title_short Remdesivir and corticosteroids in the treatment of hospitalized COVID-19 patients
title_full Remdesivir and corticosteroids in the treatment of hospitalized COVID-19 patients
title_fullStr Remdesivir and corticosteroids in the treatment of hospitalized COVID-19 patients
title_full_unstemmed Remdesivir and corticosteroids in the treatment of hospitalized COVID-19 patients
title_sort Remdesivir and corticosteroids in the treatment of hospitalized COVID-19 patients
author Coelho, Luís
author_facet Coelho, Luís
Falcão, Fatima
Povoa, Pedro
Viegas, Erica
Martins, Antonio Pais
Carmo, Eduarda
Fonseca, Candida
Campos, Luis
Mansinho, Kamal
Carmo, Inês
Soares, Joana
Solano, Mariana
Mendes, Dina
Miranda, Ana Cláudia
Carvalho, Antonio
Mirco, Ana
Farinha, Helena
Aldir, Isabel
Correia, José
author_role author
author2 Falcão, Fatima
Povoa, Pedro
Viegas, Erica
Martins, Antonio Pais
Carmo, Eduarda
Fonseca, Candida
Campos, Luis
Mansinho, Kamal
Carmo, Inês
Soares, Joana
Solano, Mariana
Mendes, Dina
Miranda, Ana Cláudia
Carvalho, Antonio
Mirco, Ana
Farinha, Helena
Aldir, Isabel
Correia, José
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Coelho, Luís
Falcão, Fatima
Povoa, Pedro
Viegas, Erica
Martins, Antonio Pais
Carmo, Eduarda
Fonseca, Candida
Campos, Luis
Mansinho, Kamal
Carmo, Inês
Soares, Joana
Solano, Mariana
Mendes, Dina
Miranda, Ana Cláudia
Carvalho, Antonio
Mirco, Ana
Farinha, Helena
Aldir, Isabel
Correia, José
dc.subject.por.fl_str_mv General
topic General
description ok
publishDate 2023
dc.date.none.fl_str_mv 2023-03-31T22:20:53Z
2023-03-18
2023-03-18T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/151476
url http://hdl.handle.net/10362/151476
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2045-2322
PURE: 57370604
https://doi.org/10.1038/s41598-023-31544-5
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1
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instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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