Effect of Cobalt and Chromium Ions on the Chlorhexidine Digluconate as Seen by Intermolecular Diffusion
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/104797 https://doi.org/10.3390/ijms222413266 |
Resumo: | Metal ions such as cobalt (II) and chromium (III) might be present in the oral cavity, as a consequence of the corrosion of Co-Cr dental alloys. The diffusion of such metal ions into the organism, carried by saliva, can cause health problems as a consequence of their toxicity, enhanced by a cumulative effect in the body. The effect of the chlorhexidine digluconate, which is commonly used in mouthwash formulations, on the transport of these salts is evaluated in this paper by using the Taylor dispersion technique, which will allow an assessment of how the presence of chlorhexidine digluconate (either in aqueous solution or in a commercial formulation) may affect the diffusion of metal ions. The ternary mutual diffusion coefficients of metal ions (Co and Cr) in the presence of chlorhexidine digluconate, in an artificial saliva media, were measured. Significant coupled diffusion of CoCl2 (and CrCl3) and chlorhexidine digluconate is observed by analysis of the non-zero values of the cross-diffusion coefficients, D12 and D21. The observed interactions between metal ions and chlorhexidine digluconate suggest that the latter might be considered as an advantageous therapeutic agent, once they contribute to the reduction of the concentration of those ions inside the mouth. |
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Effect of Cobalt and Chromium Ions on the Chlorhexidine Digluconate as Seen by Intermolecular Diffusionartificial salivacobalt chloridechromium chloridediffusion coefficientschlorhexidine digluconateChlorhexidineChromiumChromium AlloysCobaltCorrosionDiffusionHumansMolecular ConformationSaliva, ArtificialMetal ions such as cobalt (II) and chromium (III) might be present in the oral cavity, as a consequence of the corrosion of Co-Cr dental alloys. The diffusion of such metal ions into the organism, carried by saliva, can cause health problems as a consequence of their toxicity, enhanced by a cumulative effect in the body. The effect of the chlorhexidine digluconate, which is commonly used in mouthwash formulations, on the transport of these salts is evaluated in this paper by using the Taylor dispersion technique, which will allow an assessment of how the presence of chlorhexidine digluconate (either in aqueous solution or in a commercial formulation) may affect the diffusion of metal ions. The ternary mutual diffusion coefficients of metal ions (Co and Cr) in the presence of chlorhexidine digluconate, in an artificial saliva media, were measured. Significant coupled diffusion of CoCl2 (and CrCl3) and chlorhexidine digluconate is observed by analysis of the non-zero values of the cross-diffusion coefficients, D12 and D21. The observed interactions between metal ions and chlorhexidine digluconate suggest that the latter might be considered as an advantageous therapeutic agent, once they contribute to the reduction of the concentration of those ions inside the mouth.MDPI2021-12-09info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/104797http://hdl.handle.net/10316/104797https://doi.org/10.3390/ijms222413266eng1422-0067Fangaia, Sónia I. G.Nicolau, Pedro M. G.Guerra, Fernando A. D. R. A.Rodrigo, M. MeliaUtzeri, GianlucaCabral, Ana M. T. D. P. V.Valente, Artur J. M.Esteso, Miguel Á.Ribeiro, Ana C. F.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-01-25T21:58:58Zoai:estudogeral.uc.pt:10316/104797Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:21:26.653973Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Effect of Cobalt and Chromium Ions on the Chlorhexidine Digluconate as Seen by Intermolecular Diffusion |
title |
Effect of Cobalt and Chromium Ions on the Chlorhexidine Digluconate as Seen by Intermolecular Diffusion |
spellingShingle |
Effect of Cobalt and Chromium Ions on the Chlorhexidine Digluconate as Seen by Intermolecular Diffusion Fangaia, Sónia I. G. artificial saliva cobalt chloride chromium chloride diffusion coefficients chlorhexidine digluconate Chlorhexidine Chromium Chromium Alloys Cobalt Corrosion Diffusion Humans Molecular Conformation Saliva, Artificial |
title_short |
Effect of Cobalt and Chromium Ions on the Chlorhexidine Digluconate as Seen by Intermolecular Diffusion |
title_full |
Effect of Cobalt and Chromium Ions on the Chlorhexidine Digluconate as Seen by Intermolecular Diffusion |
title_fullStr |
Effect of Cobalt and Chromium Ions on the Chlorhexidine Digluconate as Seen by Intermolecular Diffusion |
title_full_unstemmed |
Effect of Cobalt and Chromium Ions on the Chlorhexidine Digluconate as Seen by Intermolecular Diffusion |
title_sort |
Effect of Cobalt and Chromium Ions on the Chlorhexidine Digluconate as Seen by Intermolecular Diffusion |
author |
Fangaia, Sónia I. G. |
author_facet |
Fangaia, Sónia I. G. Nicolau, Pedro M. G. Guerra, Fernando A. D. R. A. Rodrigo, M. Melia Utzeri, Gianluca Cabral, Ana M. T. D. P. V. Valente, Artur J. M. Esteso, Miguel Á. Ribeiro, Ana C. F. |
author_role |
author |
author2 |
Nicolau, Pedro M. G. Guerra, Fernando A. D. R. A. Rodrigo, M. Melia Utzeri, Gianluca Cabral, Ana M. T. D. P. V. Valente, Artur J. M. Esteso, Miguel Á. Ribeiro, Ana C. F. |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Fangaia, Sónia I. G. Nicolau, Pedro M. G. Guerra, Fernando A. D. R. A. Rodrigo, M. Melia Utzeri, Gianluca Cabral, Ana M. T. D. P. V. Valente, Artur J. M. Esteso, Miguel Á. Ribeiro, Ana C. F. |
dc.subject.por.fl_str_mv |
artificial saliva cobalt chloride chromium chloride diffusion coefficients chlorhexidine digluconate Chlorhexidine Chromium Chromium Alloys Cobalt Corrosion Diffusion Humans Molecular Conformation Saliva, Artificial |
topic |
artificial saliva cobalt chloride chromium chloride diffusion coefficients chlorhexidine digluconate Chlorhexidine Chromium Chromium Alloys Cobalt Corrosion Diffusion Humans Molecular Conformation Saliva, Artificial |
description |
Metal ions such as cobalt (II) and chromium (III) might be present in the oral cavity, as a consequence of the corrosion of Co-Cr dental alloys. The diffusion of such metal ions into the organism, carried by saliva, can cause health problems as a consequence of their toxicity, enhanced by a cumulative effect in the body. The effect of the chlorhexidine digluconate, which is commonly used in mouthwash formulations, on the transport of these salts is evaluated in this paper by using the Taylor dispersion technique, which will allow an assessment of how the presence of chlorhexidine digluconate (either in aqueous solution or in a commercial formulation) may affect the diffusion of metal ions. The ternary mutual diffusion coefficients of metal ions (Co and Cr) in the presence of chlorhexidine digluconate, in an artificial saliva media, were measured. Significant coupled diffusion of CoCl2 (and CrCl3) and chlorhexidine digluconate is observed by analysis of the non-zero values of the cross-diffusion coefficients, D12 and D21. The observed interactions between metal ions and chlorhexidine digluconate suggest that the latter might be considered as an advantageous therapeutic agent, once they contribute to the reduction of the concentration of those ions inside the mouth. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-12-09 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/104797 http://hdl.handle.net/10316/104797 https://doi.org/10.3390/ijms222413266 |
url |
http://hdl.handle.net/10316/104797 https://doi.org/10.3390/ijms222413266 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1422-0067 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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