Effect of Cobalt and Chromium Ions on the Chlorhexidine Digluconate as Seen by Intermolecular Diffusion

Detalhes bibliográficos
Autor(a) principal: Fangaia, Sónia I. G.
Data de Publicação: 2021
Outros Autores: Nicolau, Pedro M. G., Guerra, Fernando A. D. R. A., Rodrigo, M. Melia, Utzeri, Gianluca, Cabral, Ana M. T. D. P. V., Valente, Artur J. M., Esteso, Miguel Á., Ribeiro, Ana C. F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/104797
https://doi.org/10.3390/ijms222413266
Resumo: Metal ions such as cobalt (II) and chromium (III) might be present in the oral cavity, as a consequence of the corrosion of Co-Cr dental alloys. The diffusion of such metal ions into the organism, carried by saliva, can cause health problems as a consequence of their toxicity, enhanced by a cumulative effect in the body. The effect of the chlorhexidine digluconate, which is commonly used in mouthwash formulations, on the transport of these salts is evaluated in this paper by using the Taylor dispersion technique, which will allow an assessment of how the presence of chlorhexidine digluconate (either in aqueous solution or in a commercial formulation) may affect the diffusion of metal ions. The ternary mutual diffusion coefficients of metal ions (Co and Cr) in the presence of chlorhexidine digluconate, in an artificial saliva media, were measured. Significant coupled diffusion of CoCl2 (and CrCl3) and chlorhexidine digluconate is observed by analysis of the non-zero values of the cross-diffusion coefficients, D12 and D21. The observed interactions between metal ions and chlorhexidine digluconate suggest that the latter might be considered as an advantageous therapeutic agent, once they contribute to the reduction of the concentration of those ions inside the mouth.
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spelling Effect of Cobalt and Chromium Ions on the Chlorhexidine Digluconate as Seen by Intermolecular Diffusionartificial salivacobalt chloridechromium chloridediffusion coefficientschlorhexidine digluconateChlorhexidineChromiumChromium AlloysCobaltCorrosionDiffusionHumansMolecular ConformationSaliva, ArtificialMetal ions such as cobalt (II) and chromium (III) might be present in the oral cavity, as a consequence of the corrosion of Co-Cr dental alloys. The diffusion of such metal ions into the organism, carried by saliva, can cause health problems as a consequence of their toxicity, enhanced by a cumulative effect in the body. The effect of the chlorhexidine digluconate, which is commonly used in mouthwash formulations, on the transport of these salts is evaluated in this paper by using the Taylor dispersion technique, which will allow an assessment of how the presence of chlorhexidine digluconate (either in aqueous solution or in a commercial formulation) may affect the diffusion of metal ions. The ternary mutual diffusion coefficients of metal ions (Co and Cr) in the presence of chlorhexidine digluconate, in an artificial saliva media, were measured. Significant coupled diffusion of CoCl2 (and CrCl3) and chlorhexidine digluconate is observed by analysis of the non-zero values of the cross-diffusion coefficients, D12 and D21. The observed interactions between metal ions and chlorhexidine digluconate suggest that the latter might be considered as an advantageous therapeutic agent, once they contribute to the reduction of the concentration of those ions inside the mouth.MDPI2021-12-09info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/104797http://hdl.handle.net/10316/104797https://doi.org/10.3390/ijms222413266eng1422-0067Fangaia, Sónia I. G.Nicolau, Pedro M. G.Guerra, Fernando A. D. R. A.Rodrigo, M. MeliaUtzeri, GianlucaCabral, Ana M. T. D. P. V.Valente, Artur J. M.Esteso, Miguel Á.Ribeiro, Ana C. F.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-01-25T21:58:58Zoai:estudogeral.uc.pt:10316/104797Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:21:26.653973Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Effect of Cobalt and Chromium Ions on the Chlorhexidine Digluconate as Seen by Intermolecular Diffusion
title Effect of Cobalt and Chromium Ions on the Chlorhexidine Digluconate as Seen by Intermolecular Diffusion
spellingShingle Effect of Cobalt and Chromium Ions on the Chlorhexidine Digluconate as Seen by Intermolecular Diffusion
Fangaia, Sónia I. G.
artificial saliva
cobalt chloride
chromium chloride
diffusion coefficients
chlorhexidine digluconate
Chlorhexidine
Chromium
Chromium Alloys
Cobalt
Corrosion
Diffusion
Humans
Molecular Conformation
Saliva, Artificial
title_short Effect of Cobalt and Chromium Ions on the Chlorhexidine Digluconate as Seen by Intermolecular Diffusion
title_full Effect of Cobalt and Chromium Ions on the Chlorhexidine Digluconate as Seen by Intermolecular Diffusion
title_fullStr Effect of Cobalt and Chromium Ions on the Chlorhexidine Digluconate as Seen by Intermolecular Diffusion
title_full_unstemmed Effect of Cobalt and Chromium Ions on the Chlorhexidine Digluconate as Seen by Intermolecular Diffusion
title_sort Effect of Cobalt and Chromium Ions on the Chlorhexidine Digluconate as Seen by Intermolecular Diffusion
author Fangaia, Sónia I. G.
author_facet Fangaia, Sónia I. G.
Nicolau, Pedro M. G.
Guerra, Fernando A. D. R. A.
Rodrigo, M. Melia
Utzeri, Gianluca
Cabral, Ana M. T. D. P. V.
Valente, Artur J. M.
Esteso, Miguel Á.
Ribeiro, Ana C. F.
author_role author
author2 Nicolau, Pedro M. G.
Guerra, Fernando A. D. R. A.
Rodrigo, M. Melia
Utzeri, Gianluca
Cabral, Ana M. T. D. P. V.
Valente, Artur J. M.
Esteso, Miguel Á.
Ribeiro, Ana C. F.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fangaia, Sónia I. G.
Nicolau, Pedro M. G.
Guerra, Fernando A. D. R. A.
Rodrigo, M. Melia
Utzeri, Gianluca
Cabral, Ana M. T. D. P. V.
Valente, Artur J. M.
Esteso, Miguel Á.
Ribeiro, Ana C. F.
dc.subject.por.fl_str_mv artificial saliva
cobalt chloride
chromium chloride
diffusion coefficients
chlorhexidine digluconate
Chlorhexidine
Chromium
Chromium Alloys
Cobalt
Corrosion
Diffusion
Humans
Molecular Conformation
Saliva, Artificial
topic artificial saliva
cobalt chloride
chromium chloride
diffusion coefficients
chlorhexidine digluconate
Chlorhexidine
Chromium
Chromium Alloys
Cobalt
Corrosion
Diffusion
Humans
Molecular Conformation
Saliva, Artificial
description Metal ions such as cobalt (II) and chromium (III) might be present in the oral cavity, as a consequence of the corrosion of Co-Cr dental alloys. The diffusion of such metal ions into the organism, carried by saliva, can cause health problems as a consequence of their toxicity, enhanced by a cumulative effect in the body. The effect of the chlorhexidine digluconate, which is commonly used in mouthwash formulations, on the transport of these salts is evaluated in this paper by using the Taylor dispersion technique, which will allow an assessment of how the presence of chlorhexidine digluconate (either in aqueous solution or in a commercial formulation) may affect the diffusion of metal ions. The ternary mutual diffusion coefficients of metal ions (Co and Cr) in the presence of chlorhexidine digluconate, in an artificial saliva media, were measured. Significant coupled diffusion of CoCl2 (and CrCl3) and chlorhexidine digluconate is observed by analysis of the non-zero values of the cross-diffusion coefficients, D12 and D21. The observed interactions between metal ions and chlorhexidine digluconate suggest that the latter might be considered as an advantageous therapeutic agent, once they contribute to the reduction of the concentration of those ions inside the mouth.
publishDate 2021
dc.date.none.fl_str_mv 2021-12-09
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/104797
http://hdl.handle.net/10316/104797
https://doi.org/10.3390/ijms222413266
url http://hdl.handle.net/10316/104797
https://doi.org/10.3390/ijms222413266
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1422-0067
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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