Levosimendan efficacy and safety : 20 Years of SIMDAX in clinical use
| Autor(a) principal: | |
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| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/44086 |
Resumo: | Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. |
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Levosimendan efficacy and safety : 20 Years of SIMDAX in clinical useAcute heart failureAdvanced heart failureHemodynamicsInodilatorInotropeNeurohormoneRegulatory clinical trialCopyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc.Levosimendan was first approved for clinical use in 2000, when authorization was granted by Swedish regulatory authorities for the hemodynamic stabilization of patients with acutely decompensated chronic heart failure (HF). In the ensuing 20 years, this distinctive inodilator, which enhances cardiac contractility through calcium sensitization and promotes vasodilatation through the opening of adenosine triphosphate–dependent potassium channels on vascular smooth muscle cells, has been approved in more than 60 jurisdictions, including most of the countries of the European Union and Latin America. Areas of clinical application have expanded considerably and now include cardiogenic shock, takotsubo cardiomyopathy, advanced HF, right ventricular failure, pulmonary hypertension, cardiac surgery, critical care, and emergency medicine. Levosimendan is currently in active clinical evaluation in the United States. Levosimendan in IV formulation is being used as a research tool in the exploration of a wide range of cardiac and noncardiac disease states. A levosimendan oral form is at present under evaluation in the management of amyotrophic lateral sclerosis. To mark the 20 years since the advent of levosimendan in clinical use, 51 experts from 23 European countries (Austria, Belgium, Croatia, Cyprus, Czech Republic, Estonia, Finland, France, Germany, Greece, Hungary, Italy, the Netherlands, Norway, Poland, Portugal, Russia, Slovenia, Spain, Sweden, Switzerland, the United Kingdom, and Ukraine) contributed to this essay, which evaluates one of the relatively few drugs to have been successfully introduced into the acute HF arena in recent times and charts a possible development trajectory for the next 20 years.Wolters Kluwer Health, Inc.Repositório da Universidade de LisboaPapp, ZoltánAgostoni, PiergiuseppeAlvarez, JulianBettex, DominiqueBouchez, StefanBrito, DulceCˇerný, VladimirComin-Colet, JosepCrespo-Leiro, Marisa GDelgado, Juan FÉdes, IstvanEremenko, Alexander AFarmakis, DimitriosFedele, FrancescoFonseca, CândidaFruhwald, SonjaGirardis, MassimoGuarracino, FabioHarjola, Veli-PekkaHeringlake, MatthiasHerpain, AntoineHeunks, Leo MAHusebye, TryggveIvancan, VišnjaKarason, KristjanKaul, SundeepKivikko, MattiKubica, JanekMasip, JosepMatskeplishvili, SimonMebazaa, AlexandreNieminen, Markku SOliva, FabrizioPapp, Julius-GyulaParissis, JohnParkhomenko, AlexanderPõder, PenttiPölzl, GerhardReinecke, AlexanderRicksten, Sven-ErikRiha, HynekRudiger, AlainSarapohja, ToniSchwinger, Robert HGToller, WolfgangTritapepe, LuigiTschöpe, CarstenWikström, Gerhardvon Lewinski, DirkVrtovec, BojanPollesello, Piero2020-07-21T12:32:55Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/44086engJournal of Cardiovascular Pharmacology: July 2020 - Volume 76 - Issue 1 - p 4-220160-244610.1097/FJC.00000000000008591533-4023info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:44:43Zoai:repositorio.ul.pt:10451/44086Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:56:41.555894Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Levosimendan efficacy and safety : 20 Years of SIMDAX in clinical use |
| title |
Levosimendan efficacy and safety : 20 Years of SIMDAX in clinical use |
| spellingShingle |
Levosimendan efficacy and safety : 20 Years of SIMDAX in clinical use Papp, Zoltán Acute heart failure Advanced heart failure Hemodynamics Inodilator Inotrope Neurohormone Regulatory clinical trial |
| title_short |
Levosimendan efficacy and safety : 20 Years of SIMDAX in clinical use |
| title_full |
Levosimendan efficacy and safety : 20 Years of SIMDAX in clinical use |
| title_fullStr |
Levosimendan efficacy and safety : 20 Years of SIMDAX in clinical use |
| title_full_unstemmed |
Levosimendan efficacy and safety : 20 Years of SIMDAX in clinical use |
| title_sort |
Levosimendan efficacy and safety : 20 Years of SIMDAX in clinical use |
| author |
Papp, Zoltán |
| author_facet |
Papp, Zoltán Agostoni, Piergiuseppe Alvarez, Julian Bettex, Dominique Bouchez, Stefan Brito, Dulce Cˇerný, Vladimir Comin-Colet, Josep Crespo-Leiro, Marisa G Delgado, Juan F Édes, Istvan Eremenko, Alexander A Farmakis, Dimitrios Fedele, Francesco Fonseca, Cândida Fruhwald, Sonja Girardis, Massimo Guarracino, Fabio Harjola, Veli-Pekka Heringlake, Matthias Herpain, Antoine Heunks, Leo MA Husebye, Tryggve Ivancan, Višnja Karason, Kristjan Kaul, Sundeep Kivikko, Matti Kubica, Janek Masip, Josep Matskeplishvili, Simon Mebazaa, Alexandre Nieminen, Markku S Oliva, Fabrizio Papp, Julius-Gyula Parissis, John Parkhomenko, Alexander Põder, Pentti Pölzl, Gerhard Reinecke, Alexander Ricksten, Sven-Erik Riha, Hynek Rudiger, Alain Sarapohja, Toni Schwinger, Robert HG Toller, Wolfgang Tritapepe, Luigi Tschöpe, Carsten Wikström, Gerhard von Lewinski, Dirk Vrtovec, Bojan Pollesello, Piero |
| author_role |
author |
| author2 |
Agostoni, Piergiuseppe Alvarez, Julian Bettex, Dominique Bouchez, Stefan Brito, Dulce Cˇerný, Vladimir Comin-Colet, Josep Crespo-Leiro, Marisa G Delgado, Juan F Édes, Istvan Eremenko, Alexander A Farmakis, Dimitrios Fedele, Francesco Fonseca, Cândida Fruhwald, Sonja Girardis, Massimo Guarracino, Fabio Harjola, Veli-Pekka Heringlake, Matthias Herpain, Antoine Heunks, Leo MA Husebye, Tryggve Ivancan, Višnja Karason, Kristjan Kaul, Sundeep Kivikko, Matti Kubica, Janek Masip, Josep Matskeplishvili, Simon Mebazaa, Alexandre Nieminen, Markku S Oliva, Fabrizio Papp, Julius-Gyula Parissis, John Parkhomenko, Alexander Põder, Pentti Pölzl, Gerhard Reinecke, Alexander Ricksten, Sven-Erik Riha, Hynek Rudiger, Alain Sarapohja, Toni Schwinger, Robert HG Toller, Wolfgang Tritapepe, Luigi Tschöpe, Carsten Wikström, Gerhard von Lewinski, Dirk Vrtovec, Bojan Pollesello, Piero |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Papp, Zoltán Agostoni, Piergiuseppe Alvarez, Julian Bettex, Dominique Bouchez, Stefan Brito, Dulce Cˇerný, Vladimir Comin-Colet, Josep Crespo-Leiro, Marisa G Delgado, Juan F Édes, Istvan Eremenko, Alexander A Farmakis, Dimitrios Fedele, Francesco Fonseca, Cândida Fruhwald, Sonja Girardis, Massimo Guarracino, Fabio Harjola, Veli-Pekka Heringlake, Matthias Herpain, Antoine Heunks, Leo MA Husebye, Tryggve Ivancan, Višnja Karason, Kristjan Kaul, Sundeep Kivikko, Matti Kubica, Janek Masip, Josep Matskeplishvili, Simon Mebazaa, Alexandre Nieminen, Markku S Oliva, Fabrizio Papp, Julius-Gyula Parissis, John Parkhomenko, Alexander Põder, Pentti Pölzl, Gerhard Reinecke, Alexander Ricksten, Sven-Erik Riha, Hynek Rudiger, Alain Sarapohja, Toni Schwinger, Robert HG Toller, Wolfgang Tritapepe, Luigi Tschöpe, Carsten Wikström, Gerhard von Lewinski, Dirk Vrtovec, Bojan Pollesello, Piero |
| dc.subject.por.fl_str_mv |
Acute heart failure Advanced heart failure Hemodynamics Inodilator Inotrope Neurohormone Regulatory clinical trial |
| topic |
Acute heart failure Advanced heart failure Hemodynamics Inodilator Inotrope Neurohormone Regulatory clinical trial |
| description |
Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020-07-21T12:32:55Z 2020 2020-01-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10451/44086 |
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http://hdl.handle.net/10451/44086 |
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eng |
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eng |
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Journal of Cardiovascular Pharmacology: July 2020 - Volume 76 - Issue 1 - p 4-22 0160-2446 10.1097/FJC.0000000000000859 1533-4023 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Wolters Kluwer Health, Inc. |
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Wolters Kluwer Health, Inc. |
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