Alterations of gray and white matter morphology in obsessive compulsive disorder

Detalhes bibliográficos
Autor(a) principal: Gonçalves, Óscar F.
Data de Publicação: 2017
Outros Autores: Sousa, Sónia Silva, Carvalho, Sandra, Leite, Jorge, Ganho, Ana, Fernandes-Gonçalves, Ana, Pocinho, Fernando, Carracedo, Angel, Sampaio, Adriana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/52077
Resumo: Background: While the ethio-pathogenesis of Obsessive-Compulsive disorder (OCD) remains unknown, there is increased evidence of widespread structural alterations in both white and gray matter in OCD patients that include, but are not restricted, to abnormalities in cortic-ostriatal-thalamo-cortical (CSTC) regions. The objective of this study was to test the existence of structural alterations in both white and gray matter in a sample of OCD patients when compared with a group of non-clinical matched controls (NCC), using voxel-based morphometry (VBM). Method: Fifteen patients with OCD and 15 NCC underwent MRI structural scanning. Results: Frontal (increased gray matter in the middle frontal gyrus) and subcortical regions (increased white matter in the pallidum) were found to be affected in patients. Additionally, temporal parietal regions were also found to be affected and highly correlated with OCD symptom severity (decrease of gray matter in the superior parietal lobe and white matter in the angular and superior temporal gyri). Conclusions: These alterations may be associated with prominent OCD symptoms, such as difficulties with inhibitory control (pallidum, angular gyrus), executive functioning (middle frontal gyris), compulsive checking (superior temporal gyrus) and visual-spatial deficits (superior parietal lobe).
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spelling Alterations of gray and white matter morphology in obsessive compulsive disorderLas alteraciones de morfologia de la sustancia blanca y gris en el trastorno obsesivo compulsivoObsessive-compulsive disorderGray matterWhite matterVoxel based morphometryTrastorno obsesivo compulsivoMateria blancaMateria grisMorfometría basada en vóxelSocial SciencesBackground: While the ethio-pathogenesis of Obsessive-Compulsive disorder (OCD) remains unknown, there is increased evidence of widespread structural alterations in both white and gray matter in OCD patients that include, but are not restricted, to abnormalities in cortic-ostriatal-thalamo-cortical (CSTC) regions. The objective of this study was to test the existence of structural alterations in both white and gray matter in a sample of OCD patients when compared with a group of non-clinical matched controls (NCC), using voxel-based morphometry (VBM). Method: Fifteen patients with OCD and 15 NCC underwent MRI structural scanning. Results: Frontal (increased gray matter in the middle frontal gyrus) and subcortical regions (increased white matter in the pallidum) were found to be affected in patients. Additionally, temporal parietal regions were also found to be affected and highly correlated with OCD symptom severity (decrease of gray matter in the superior parietal lobe and white matter in the angular and superior temporal gyri). Conclusions: These alterations may be associated with prominent OCD symptoms, such as difficulties with inhibitory control (pallidum, angular gyrus), executive functioning (middle frontal gyris), compulsive checking (superior temporal gyrus) and visual-spatial deficits (superior parietal lobe).Antecedentes: mientras que la etiopatogenia del trastorno obsesivo-compulsivo (TOC) sigue siendo desconocida, hay una mayor evidencia en las personas que sufren este trastorno de alteraciones estructurales que incluyen, pero no se limitan, a anormalidades en regiones cortico-estriado-tálamo-corticales (CSTC). El objetivo de este estudio fue comprobar la existencia de alteraciones estructurales tanto en la materia blanca como en la materia gris en una muestra de pacientes con TOC en comparación con un grupo de controles no clínicos (NCC), utilizándose para ello análisis morfométricos basados en “voxel” (VBM). Método: quince pacientes con TOC y quince NCC fueron estudiados mediante resonancia magnética estrutural. Resultados: se encontraron alteraciones en los pacientes en regiones frontales (aumento de la materia gris en la circunvolución frontal media) y subcorticales (aumento de la materia blanca en el pallidum). Además, también se encontraron afectadas regiones témporo-parietales con una alta correlación con la gravedad de los síntomas del TOC (disminución de la materia gris en el lóbulo parietal superior y de la materia blanca en las circunvoluciones temporales angular y superior). Conclusiones: las alteraciones encontradas pueden estar asociados con síntomas predominantes en el TOC, como difi cultades en el control inhibitorio (pallidum, giro angular), función ejecutiva (circunvolución frontal media), verifi caciones compulsivas (circunvolución temporal superior) y défi cit visual-espacial (lóbulo parietal superior).Oscar F. Gonsalves was funded by the Brazilian National Counsel for Scientific and Technological Development (CNPq) as a Special Visiting Researcher of the Science Without Borders program (grant number: 401143/2014-7). This study was partially conducted at the Neuropsychophysiology Lab from the Psychology Research Centre (UID/PSI/01662/2013), University of Minho, and supported by the Portuguese Foundation for Science and Technology and the Portuguese Ministry of Science, Technology and Higher Education through national funds and co-financed by FEDER through COMPETE2020 under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007653). This work was also supported by the Portuguese Foundation for Science and Technology (FCT) and European Union (FSE-POPH) with two individual grants (SFRH/BPD/86041/2012 and SFRH/BPD/86027/2012).info:eu-repo/semantics/publishedVersionColegio Oficial de Psicólogos del Principado de AsturiasUniversidade do MinhoGonçalves, Óscar F.Sousa, Sónia SilvaCarvalho, SandraLeite, JorgeGanho, AnaFernandes-Gonçalves, AnaPocinho, FernandoCarracedo, AngelSampaio, Adriana20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/52077eng0214-991510.7334/psicothema2016.8628126056info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:18:47Zoai:repositorium.sdum.uminho.pt:1822/52077Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:11:38.254349Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Alterations of gray and white matter morphology in obsessive compulsive disorder
Las alteraciones de morfologia de la sustancia blanca y gris en el trastorno obsesivo compulsivo
title Alterations of gray and white matter morphology in obsessive compulsive disorder
spellingShingle Alterations of gray and white matter morphology in obsessive compulsive disorder
Gonçalves, Óscar F.
Obsessive-compulsive disorder
Gray matter
White matter
Voxel based morphometry
Trastorno obsesivo compulsivo
Materia blanca
Materia gris
Morfometría basada en vóxel
Social Sciences
title_short Alterations of gray and white matter morphology in obsessive compulsive disorder
title_full Alterations of gray and white matter morphology in obsessive compulsive disorder
title_fullStr Alterations of gray and white matter morphology in obsessive compulsive disorder
title_full_unstemmed Alterations of gray and white matter morphology in obsessive compulsive disorder
title_sort Alterations of gray and white matter morphology in obsessive compulsive disorder
author Gonçalves, Óscar F.
author_facet Gonçalves, Óscar F.
Sousa, Sónia Silva
Carvalho, Sandra
Leite, Jorge
Ganho, Ana
Fernandes-Gonçalves, Ana
Pocinho, Fernando
Carracedo, Angel
Sampaio, Adriana
author_role author
author2 Sousa, Sónia Silva
Carvalho, Sandra
Leite, Jorge
Ganho, Ana
Fernandes-Gonçalves, Ana
Pocinho, Fernando
Carracedo, Angel
Sampaio, Adriana
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Gonçalves, Óscar F.
Sousa, Sónia Silva
Carvalho, Sandra
Leite, Jorge
Ganho, Ana
Fernandes-Gonçalves, Ana
Pocinho, Fernando
Carracedo, Angel
Sampaio, Adriana
dc.subject.por.fl_str_mv Obsessive-compulsive disorder
Gray matter
White matter
Voxel based morphometry
Trastorno obsesivo compulsivo
Materia blanca
Materia gris
Morfometría basada en vóxel
Social Sciences
topic Obsessive-compulsive disorder
Gray matter
White matter
Voxel based morphometry
Trastorno obsesivo compulsivo
Materia blanca
Materia gris
Morfometría basada en vóxel
Social Sciences
description Background: While the ethio-pathogenesis of Obsessive-Compulsive disorder (OCD) remains unknown, there is increased evidence of widespread structural alterations in both white and gray matter in OCD patients that include, but are not restricted, to abnormalities in cortic-ostriatal-thalamo-cortical (CSTC) regions. The objective of this study was to test the existence of structural alterations in both white and gray matter in a sample of OCD patients when compared with a group of non-clinical matched controls (NCC), using voxel-based morphometry (VBM). Method: Fifteen patients with OCD and 15 NCC underwent MRI structural scanning. Results: Frontal (increased gray matter in the middle frontal gyrus) and subcortical regions (increased white matter in the pallidum) were found to be affected in patients. Additionally, temporal parietal regions were also found to be affected and highly correlated with OCD symptom severity (decrease of gray matter in the superior parietal lobe and white matter in the angular and superior temporal gyri). Conclusions: These alterations may be associated with prominent OCD symptoms, such as difficulties with inhibitory control (pallidum, angular gyrus), executive functioning (middle frontal gyris), compulsive checking (superior temporal gyrus) and visual-spatial deficits (superior parietal lobe).
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/52077
url http://hdl.handle.net/1822/52077
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0214-9915
10.7334/psicothema2016.86
28126056
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Colegio Oficial de Psicólogos del Principado de Asturias
publisher.none.fl_str_mv Colegio Oficial de Psicólogos del Principado de Asturias
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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