New iron(II) cyclopentadienyl derivative complexes: synthesis and antitumor activity against human leucemia cancer cells
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.21/4951 |
Resumo: | A new family of "Fe-II(eta(5)-C5H5)" half sandwich compounds bearing a N-heteroaromatic ligand coordinated to the iron center by a nitrile functional group has been synthesized and fully characterized by NMR and UV-Vis spectroscopy. X-ray analysis of single crystal was achieved for complexes 1 and 3, which crystallized in the monoclinic P2(1)/c and monoclinic P2(1)/n space groups, respectively. Studies of interaction of these five new complexes with plasmid pBR322 DNA by atomic force microscopy showed very strong and different types of interaction. Antiproliferative tests were examined on human leukemia cancer cells (HL-60) using the MTT assay, and the IC50 values revealed excellent antiproliferative activity compared to cisplatin. (C) 2014 Elsevier B.V. All rights reserved. |
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New iron(II) cyclopentadienyl derivative complexes: synthesis and antitumor activity against human leucemia cancer cellsIron(II)CyclopentadienylAtomic Force Microscopy (AFM)Leukemia Cancer CellsApoptosisA new family of "Fe-II(eta(5)-C5H5)" half sandwich compounds bearing a N-heteroaromatic ligand coordinated to the iron center by a nitrile functional group has been synthesized and fully characterized by NMR and UV-Vis spectroscopy. X-ray analysis of single crystal was achieved for complexes 1 and 3, which crystallized in the monoclinic P2(1)/c and monoclinic P2(1)/n space groups, respectively. Studies of interaction of these five new complexes with plasmid pBR322 DNA by atomic force microscopy showed very strong and different types of interaction. Antiproliferative tests were examined on human leukemia cancer cells (HL-60) using the MTT assay, and the IC50 values revealed excellent antiproliferative activity compared to cisplatin. (C) 2014 Elsevier B.V. All rights reserved.Elsevier Science SARCIPLValente, AndreiaSantos, Ana MargaridaCôrte-Real, LeonorRobalo, Maria PaulaMoreno, VirtudesFont-Bardia, MerceCalvet, TeresaLorenzo, JuliaGarcia, M. Helena2015-08-24T13:22:59Z2014-042014-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/4951engVALENTE, Andreia; [et al] – New Iron(II) Cyclopentadienyl derivative complexes: Synthesis and antitumor activity against human leucemia cancer cells. Journal of Organometallic Chemistry. ISSN: 0022-328X. Vol. 756 (2104), pp. 52-600022-328X10.1016/j.jorganchem.2014.01.027metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T09:47:42Zoai:repositorio.ipl.pt:10400.21/4951Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:14:18.501028Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
New iron(II) cyclopentadienyl derivative complexes: synthesis and antitumor activity against human leucemia cancer cells |
title |
New iron(II) cyclopentadienyl derivative complexes: synthesis and antitumor activity against human leucemia cancer cells |
spellingShingle |
New iron(II) cyclopentadienyl derivative complexes: synthesis and antitumor activity against human leucemia cancer cells Valente, Andreia Iron(II) Cyclopentadienyl Atomic Force Microscopy (AFM) Leukemia Cancer Cells Apoptosis |
title_short |
New iron(II) cyclopentadienyl derivative complexes: synthesis and antitumor activity against human leucemia cancer cells |
title_full |
New iron(II) cyclopentadienyl derivative complexes: synthesis and antitumor activity against human leucemia cancer cells |
title_fullStr |
New iron(II) cyclopentadienyl derivative complexes: synthesis and antitumor activity against human leucemia cancer cells |
title_full_unstemmed |
New iron(II) cyclopentadienyl derivative complexes: synthesis and antitumor activity against human leucemia cancer cells |
title_sort |
New iron(II) cyclopentadienyl derivative complexes: synthesis and antitumor activity against human leucemia cancer cells |
author |
Valente, Andreia |
author_facet |
Valente, Andreia Santos, Ana Margarida Côrte-Real, Leonor Robalo, Maria Paula Moreno, Virtudes Font-Bardia, Merce Calvet, Teresa Lorenzo, Julia Garcia, M. Helena |
author_role |
author |
author2 |
Santos, Ana Margarida Côrte-Real, Leonor Robalo, Maria Paula Moreno, Virtudes Font-Bardia, Merce Calvet, Teresa Lorenzo, Julia Garcia, M. Helena |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
RCIPL |
dc.contributor.author.fl_str_mv |
Valente, Andreia Santos, Ana Margarida Côrte-Real, Leonor Robalo, Maria Paula Moreno, Virtudes Font-Bardia, Merce Calvet, Teresa Lorenzo, Julia Garcia, M. Helena |
dc.subject.por.fl_str_mv |
Iron(II) Cyclopentadienyl Atomic Force Microscopy (AFM) Leukemia Cancer Cells Apoptosis |
topic |
Iron(II) Cyclopentadienyl Atomic Force Microscopy (AFM) Leukemia Cancer Cells Apoptosis |
description |
A new family of "Fe-II(eta(5)-C5H5)" half sandwich compounds bearing a N-heteroaromatic ligand coordinated to the iron center by a nitrile functional group has been synthesized and fully characterized by NMR and UV-Vis spectroscopy. X-ray analysis of single crystal was achieved for complexes 1 and 3, which crystallized in the monoclinic P2(1)/c and monoclinic P2(1)/n space groups, respectively. Studies of interaction of these five new complexes with plasmid pBR322 DNA by atomic force microscopy showed very strong and different types of interaction. Antiproliferative tests were examined on human leukemia cancer cells (HL-60) using the MTT assay, and the IC50 values revealed excellent antiproliferative activity compared to cisplatin. (C) 2014 Elsevier B.V. All rights reserved. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-04 2014-04-01T00:00:00Z 2015-08-24T13:22:59Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.21/4951 |
url |
http://hdl.handle.net/10400.21/4951 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
VALENTE, Andreia; [et al] – New Iron(II) Cyclopentadienyl derivative complexes: Synthesis and antitumor activity against human leucemia cancer cells. Journal of Organometallic Chemistry. ISSN: 0022-328X. Vol. 756 (2104), pp. 52-60 0022-328X 10.1016/j.jorganchem.2014.01.027 |
dc.rights.driver.fl_str_mv |
metadata only access info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
metadata only access |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Science SA |
publisher.none.fl_str_mv |
Elsevier Science SA |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1817551502230683648 |