New iron(II) cyclopentadienyl derivative complexes: synthesis and antitumor activity against human leucemia cancer cells

Detalhes bibliográficos
Autor(a) principal: Valente, Andreia
Data de Publicação: 2014
Outros Autores: Santos, Ana Margarida, Côrte-Real, Leonor, Robalo, Maria Paula, Moreno, Virtudes, Font-Bardia, Merce, Calvet, Teresa, Lorenzo, Julia, Garcia, M. Helena
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.21/4951
Resumo: A new family of "Fe-II(eta(5)-C5H5)" half sandwich compounds bearing a N-heteroaromatic ligand coordinated to the iron center by a nitrile functional group has been synthesized and fully characterized by NMR and UV-Vis spectroscopy. X-ray analysis of single crystal was achieved for complexes 1 and 3, which crystallized in the monoclinic P2(1)/c and monoclinic P2(1)/n space groups, respectively. Studies of interaction of these five new complexes with plasmid pBR322 DNA by atomic force microscopy showed very strong and different types of interaction. Antiproliferative tests were examined on human leukemia cancer cells (HL-60) using the MTT assay, and the IC50 values revealed excellent antiproliferative activity compared to cisplatin. (C) 2014 Elsevier B.V. All rights reserved.
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spelling New iron(II) cyclopentadienyl derivative complexes: synthesis and antitumor activity against human leucemia cancer cellsIron(II)CyclopentadienylAtomic Force Microscopy (AFM)Leukemia Cancer CellsApoptosisA new family of "Fe-II(eta(5)-C5H5)" half sandwich compounds bearing a N-heteroaromatic ligand coordinated to the iron center by a nitrile functional group has been synthesized and fully characterized by NMR and UV-Vis spectroscopy. X-ray analysis of single crystal was achieved for complexes 1 and 3, which crystallized in the monoclinic P2(1)/c and monoclinic P2(1)/n space groups, respectively. Studies of interaction of these five new complexes with plasmid pBR322 DNA by atomic force microscopy showed very strong and different types of interaction. Antiproliferative tests were examined on human leukemia cancer cells (HL-60) using the MTT assay, and the IC50 values revealed excellent antiproliferative activity compared to cisplatin. (C) 2014 Elsevier B.V. All rights reserved.Elsevier Science SARCIPLValente, AndreiaSantos, Ana MargaridaCôrte-Real, LeonorRobalo, Maria PaulaMoreno, VirtudesFont-Bardia, MerceCalvet, TeresaLorenzo, JuliaGarcia, M. Helena2015-08-24T13:22:59Z2014-042014-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/4951engVALENTE, Andreia; [et al] – New Iron(II) Cyclopentadienyl derivative complexes: Synthesis and antitumor activity against human leucemia cancer cells. Journal of Organometallic Chemistry. ISSN: 0022-328X. Vol. 756 (2104), pp. 52-600022-328X10.1016/j.jorganchem.2014.01.027metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T09:47:42Zoai:repositorio.ipl.pt:10400.21/4951Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:14:18.501028Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv New iron(II) cyclopentadienyl derivative complexes: synthesis and antitumor activity against human leucemia cancer cells
title New iron(II) cyclopentadienyl derivative complexes: synthesis and antitumor activity against human leucemia cancer cells
spellingShingle New iron(II) cyclopentadienyl derivative complexes: synthesis and antitumor activity against human leucemia cancer cells
Valente, Andreia
Iron(II)
Cyclopentadienyl
Atomic Force Microscopy (AFM)
Leukemia Cancer Cells
Apoptosis
title_short New iron(II) cyclopentadienyl derivative complexes: synthesis and antitumor activity against human leucemia cancer cells
title_full New iron(II) cyclopentadienyl derivative complexes: synthesis and antitumor activity against human leucemia cancer cells
title_fullStr New iron(II) cyclopentadienyl derivative complexes: synthesis and antitumor activity against human leucemia cancer cells
title_full_unstemmed New iron(II) cyclopentadienyl derivative complexes: synthesis and antitumor activity against human leucemia cancer cells
title_sort New iron(II) cyclopentadienyl derivative complexes: synthesis and antitumor activity against human leucemia cancer cells
author Valente, Andreia
author_facet Valente, Andreia
Santos, Ana Margarida
Côrte-Real, Leonor
Robalo, Maria Paula
Moreno, Virtudes
Font-Bardia, Merce
Calvet, Teresa
Lorenzo, Julia
Garcia, M. Helena
author_role author
author2 Santos, Ana Margarida
Côrte-Real, Leonor
Robalo, Maria Paula
Moreno, Virtudes
Font-Bardia, Merce
Calvet, Teresa
Lorenzo, Julia
Garcia, M. Helena
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv RCIPL
dc.contributor.author.fl_str_mv Valente, Andreia
Santos, Ana Margarida
Côrte-Real, Leonor
Robalo, Maria Paula
Moreno, Virtudes
Font-Bardia, Merce
Calvet, Teresa
Lorenzo, Julia
Garcia, M. Helena
dc.subject.por.fl_str_mv Iron(II)
Cyclopentadienyl
Atomic Force Microscopy (AFM)
Leukemia Cancer Cells
Apoptosis
topic Iron(II)
Cyclopentadienyl
Atomic Force Microscopy (AFM)
Leukemia Cancer Cells
Apoptosis
description A new family of "Fe-II(eta(5)-C5H5)" half sandwich compounds bearing a N-heteroaromatic ligand coordinated to the iron center by a nitrile functional group has been synthesized and fully characterized by NMR and UV-Vis spectroscopy. X-ray analysis of single crystal was achieved for complexes 1 and 3, which crystallized in the monoclinic P2(1)/c and monoclinic P2(1)/n space groups, respectively. Studies of interaction of these five new complexes with plasmid pBR322 DNA by atomic force microscopy showed very strong and different types of interaction. Antiproliferative tests were examined on human leukemia cancer cells (HL-60) using the MTT assay, and the IC50 values revealed excellent antiproliferative activity compared to cisplatin. (C) 2014 Elsevier B.V. All rights reserved.
publishDate 2014
dc.date.none.fl_str_mv 2014-04
2014-04-01T00:00:00Z
2015-08-24T13:22:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.21/4951
url http://hdl.handle.net/10400.21/4951
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv VALENTE, Andreia; [et al] – New Iron(II) Cyclopentadienyl derivative complexes: Synthesis and antitumor activity against human leucemia cancer cells. Journal of Organometallic Chemistry. ISSN: 0022-328X. Vol. 756 (2104), pp. 52-60
0022-328X
10.1016/j.jorganchem.2014.01.027
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier Science SA
publisher.none.fl_str_mv Elsevier Science SA
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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