Tissue depletion of five antibiotic residues in farmed European seabass (Dicentrarchus labrax)

Detalhes bibliográficos
Autor(a) principal: Rosa, João
Data de Publicação: 2019
Outros Autores: Leston, Sara, Freitas, Andreia, Barbosa, Jorge, Rema, Paulo, Dias, Jorge, Lemos, Marco F. L., Pardal, Miguel Ângelo, Ramos, Fernando
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.8/4188
Resumo: Financial support was given by FEDER through the Operational Program for Competitiveness Factors and COMPETE, through FCT and the Portuguese Foundation for Science and Technology under project PTDC/AGR/ALI/122119/2010, and projects ReNATURE - Valorization of the Natural Endogenous Resources of the Centro Region (Centro 2020, Centro-01-0145-FEDER-000007) and SmarBioR - Smart Valorization of Endogenous Marine Biological Resources Under a Changing Climate (Centro 2020, Centro-01-0145-FEDER-000018), cofunded by Centro 2020 Program, Portugal 2020, European Union, through the European Regional Development Fund. Authors also acknowledge FCT for the grant attributed to Sara Leston (grant SFRH/ BPD/91828/2012) and to João Rosa (grant SFRH/BD/102008/2014). The funding source did not interfere with the study design, or in the collection, analysis or interpretation of the data. It also had no involvement in the writing of the report and in the decision to submit the present manuscript for publication.
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spelling Tissue depletion of five antibiotic residues in farmed European seabass (Dicentrarchus labrax)SeabassMedicated feedWithdrawal timesRetentionResiduesFinancial support was given by FEDER through the Operational Program for Competitiveness Factors and COMPETE, through FCT and the Portuguese Foundation for Science and Technology under project PTDC/AGR/ALI/122119/2010, and projects ReNATURE - Valorization of the Natural Endogenous Resources of the Centro Region (Centro 2020, Centro-01-0145-FEDER-000007) and SmarBioR - Smart Valorization of Endogenous Marine Biological Resources Under a Changing Climate (Centro 2020, Centro-01-0145-FEDER-000018), cofunded by Centro 2020 Program, Portugal 2020, European Union, through the European Regional Development Fund. Authors also acknowledge FCT for the grant attributed to Sara Leston (grant SFRH/ BPD/91828/2012) and to João Rosa (grant SFRH/BD/102008/2014). The funding source did not interfere with the study design, or in the collection, analysis or interpretation of the data. It also had no involvement in the writing of the report and in the decision to submit the present manuscript for publication.Concerns about antibiotic use led to stricter legislations and overall better practices in aquaculture production. However, depletion time periods in tissues vary greatly with different antimicrobials, fish species, or experimental setup. In the present work, five drugs (sulfadiazine (SDZ), trimethoprim (TRI), flumequine (FLU), oxolinic acid (OXO), and oxytetracycline (OTC)) were incorporated into medicated feed, and their retention in European seabass muscle tissues assessed. Juveniles were placed in 300 L tanks at 18 °C and were manually fed with medicated feeds for a 7 day period (two concentrations per antimicrobial, ranging from 6 to 220 mg kg−1 , which were based on previous studies on the occurrence of these antimicrobials). Residues were analyzed through a multi-class quantification method (UHPLC-MS/MS). Data on residues concentration through time followed a one-compartment model, with TRI concentrations above the established Maximum Residue Level (MRL) throughout the experiment. Similarly, OTC concentrations at the highest dose were also above 100 μg kg−1 up to 14 days after the medication period. Results obtained for TRI may indicate the presence of a dose dependency for this antimicrobial. FLU concentrations in muscle samples were the lowest through time (Cday7 of 279.70 and 386.63 μg kg−1 , for prophylactic and therapeutic treatments, respectively). Half-life values of 14.37, 10.87, 5.36, 7.20, and 27.22 h (prophylactic treatment), and 20.95, 8.41, 5.61, 11.22, and 17.99 h (therapeutic treatment), were determined for SDZ, TRI, FLU, OXO, and OTC, respectively. Withdrawal times of 0, 2, and 5 days were determined for FLU, OXO, and SDZ, but sampling times for OTC and TRI should be longer, since antimicrobial concentrations were above the MRL 14 days after the end of the feeding period with medicated feed. Therefore, special attention should be given since they are the most used antibiotics in aquaculture and European seabass plays a major part in human nutrition in the Mediterranean region.IC-OnlineRosa, JoãoLeston, SaraFreitas, AndreiaBarbosa, JorgeRema, PauloDias, JorgeLemos, Marco F. L.Pardal, Miguel ÂngeloRamos, Fernando2019-10-11T14:01:54Z20192019-10-07T10:48:04Z2019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/4188engRosa, J., Leston, S., Freitas, A., Barbosa, J., Ramos, F., Pardal, M. A., … Lemos, M. F. L. (2019). Tissue depletion of five antibiotic residues in farmed European seabass (Dicentrarchus labrax). Aquaculture, 498, 413–421. https://doi.org/10.1016/j.aquaculture.2018.08.035cv-prod-14301310.1016/j.aquaculture.2018.08.035metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-17T15:48:49Zoai:iconline.ipleiria.pt:10400.8/4188Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:48:07.733425Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Tissue depletion of five antibiotic residues in farmed European seabass (Dicentrarchus labrax)
title Tissue depletion of five antibiotic residues in farmed European seabass (Dicentrarchus labrax)
spellingShingle Tissue depletion of five antibiotic residues in farmed European seabass (Dicentrarchus labrax)
Rosa, João
Seabass
Medicated feed
Withdrawal times
Retention
Residues
title_short Tissue depletion of five antibiotic residues in farmed European seabass (Dicentrarchus labrax)
title_full Tissue depletion of five antibiotic residues in farmed European seabass (Dicentrarchus labrax)
title_fullStr Tissue depletion of five antibiotic residues in farmed European seabass (Dicentrarchus labrax)
title_full_unstemmed Tissue depletion of five antibiotic residues in farmed European seabass (Dicentrarchus labrax)
title_sort Tissue depletion of five antibiotic residues in farmed European seabass (Dicentrarchus labrax)
author Rosa, João
author_facet Rosa, João
Leston, Sara
Freitas, Andreia
Barbosa, Jorge
Rema, Paulo
Dias, Jorge
Lemos, Marco F. L.
Pardal, Miguel Ângelo
Ramos, Fernando
author_role author
author2 Leston, Sara
Freitas, Andreia
Barbosa, Jorge
Rema, Paulo
Dias, Jorge
Lemos, Marco F. L.
Pardal, Miguel Ângelo
Ramos, Fernando
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv IC-Online
dc.contributor.author.fl_str_mv Rosa, João
Leston, Sara
Freitas, Andreia
Barbosa, Jorge
Rema, Paulo
Dias, Jorge
Lemos, Marco F. L.
Pardal, Miguel Ângelo
Ramos, Fernando
dc.subject.por.fl_str_mv Seabass
Medicated feed
Withdrawal times
Retention
Residues
topic Seabass
Medicated feed
Withdrawal times
Retention
Residues
description Financial support was given by FEDER through the Operational Program for Competitiveness Factors and COMPETE, through FCT and the Portuguese Foundation for Science and Technology under project PTDC/AGR/ALI/122119/2010, and projects ReNATURE - Valorization of the Natural Endogenous Resources of the Centro Region (Centro 2020, Centro-01-0145-FEDER-000007) and SmarBioR - Smart Valorization of Endogenous Marine Biological Resources Under a Changing Climate (Centro 2020, Centro-01-0145-FEDER-000018), cofunded by Centro 2020 Program, Portugal 2020, European Union, through the European Regional Development Fund. Authors also acknowledge FCT for the grant attributed to Sara Leston (grant SFRH/ BPD/91828/2012) and to João Rosa (grant SFRH/BD/102008/2014). The funding source did not interfere with the study design, or in the collection, analysis or interpretation of the data. It also had no involvement in the writing of the report and in the decision to submit the present manuscript for publication.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-11T14:01:54Z
2019
2019-10-07T10:48:04Z
2019-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.8/4188
url http://hdl.handle.net/10400.8/4188
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Rosa, J., Leston, S., Freitas, A., Barbosa, J., Ramos, F., Pardal, M. A., … Lemos, M. F. L. (2019). Tissue depletion of five antibiotic residues in farmed European seabass (Dicentrarchus labrax). Aquaculture, 498, 413–421. https://doi.org/10.1016/j.aquaculture.2018.08.035
cv-prod-143013
10.1016/j.aquaculture.2018.08.035
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dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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