The impact of resveratrol-enriched bread on cardiac remodeling in a preclinical model of diabetes
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10174/36355 |
Resumo: | The World Health Organization aims to stop the rise of diabetes by 2025, and diet is one of the most efficient non-pharmacological strategies used to prevent it. Resveratrol (RSV) is a natural compound with anti-diabetic properties, and incorporating it into bread is a suitable way to make it more accessible to consumers as it can be included as part of their daily diet. This study aimed to evaluate the effect of RSV-enriched bread in preventing early type 2 diabetes cardiomyopathy in vivo. Male Sprague Dawley rats (3 weeks old) were divided into four groups: controls with plain bread (CB) and RSV bread (CBR), and diabetics with plain bread (DB) and RSV bread (DBR). Type 2 diabetes was induced by adding fructose to the drinking water for two weeks followed by an injection of streptozotocin (STZ) (40 mg/kg). Then, plain bread and RSV bread (10 mg RSV/kg body weight) were included in the rats’ diet for four weeks. Cardiac function, anthropometric, and systemic biochemical parameters were monitored, as well as the histology of the heart and molecular markers of regeneration, metabolism, and oxidative stress. Data showed that an RSV bread diet decreased the polydipsia and body weight loss observed in the early stages of the disease. At the cardiac level, an RSV bread diet diminished fibrosis but did not counteract the dysfunction and metabolic changes seen in fructose-fed STZ-injected rats. |
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The impact of resveratrol-enriched bread on cardiac remodeling in a preclinical model of diabetesThe World Health Organization aims to stop the rise of diabetes by 2025, and diet is one of the most efficient non-pharmacological strategies used to prevent it. Resveratrol (RSV) is a natural compound with anti-diabetic properties, and incorporating it into bread is a suitable way to make it more accessible to consumers as it can be included as part of their daily diet. This study aimed to evaluate the effect of RSV-enriched bread in preventing early type 2 diabetes cardiomyopathy in vivo. Male Sprague Dawley rats (3 weeks old) were divided into four groups: controls with plain bread (CB) and RSV bread (CBR), and diabetics with plain bread (DB) and RSV bread (DBR). Type 2 diabetes was induced by adding fructose to the drinking water for two weeks followed by an injection of streptozotocin (STZ) (40 mg/kg). Then, plain bread and RSV bread (10 mg RSV/kg body weight) were included in the rats’ diet for four weeks. Cardiac function, anthropometric, and systemic biochemical parameters were monitored, as well as the histology of the heart and molecular markers of regeneration, metabolism, and oxidative stress. Data showed that an RSV bread diet decreased the polydipsia and body weight loss observed in the early stages of the disease. At the cardiac level, an RSV bread diet diminished fibrosis but did not counteract the dysfunction and metabolic changes seen in fructose-fed STZ-injected rats.Antioxidants2024-03-11T17:13:15Z2024-03-112023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10174/36355http://hdl.handle.net/10174/36355engSilva AFR, Silva-Reis R, Ferreira R, Oliveira PA, Faustino-Rocha AI, Lurdes Pinto ML, Coimbra MA, Silva AMS, Cardoso S. 2023. The impact of resveratrol-enriched bread on cardiac remodeling in a preclinical model of diabetes. Antioxidants 12(5): 1066. Doi: 10.3390/antiox12051066. https://www.mdpi.com/2076-3921/12/5/1066https://www.mdpi.com/2076-3921/12/5/1066ndndndndndndndndndSilva, AFRSilva-Reis, RFerreira, ROliveira, PAFaustino-Rocha, AIPinto, MLCoimbra, MASilva, AMSCardoso, Sinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-12T01:46:49Zoai:dspace.uevora.pt:10174/36355Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T04:00:25.914902Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The impact of resveratrol-enriched bread on cardiac remodeling in a preclinical model of diabetes |
title |
The impact of resveratrol-enriched bread on cardiac remodeling in a preclinical model of diabetes |
spellingShingle |
The impact of resveratrol-enriched bread on cardiac remodeling in a preclinical model of diabetes Silva, AFR |
title_short |
The impact of resveratrol-enriched bread on cardiac remodeling in a preclinical model of diabetes |
title_full |
The impact of resveratrol-enriched bread on cardiac remodeling in a preclinical model of diabetes |
title_fullStr |
The impact of resveratrol-enriched bread on cardiac remodeling in a preclinical model of diabetes |
title_full_unstemmed |
The impact of resveratrol-enriched bread on cardiac remodeling in a preclinical model of diabetes |
title_sort |
The impact of resveratrol-enriched bread on cardiac remodeling in a preclinical model of diabetes |
author |
Silva, AFR |
author_facet |
Silva, AFR Silva-Reis, R Ferreira, R Oliveira, PA Faustino-Rocha, AI Pinto, ML Coimbra, MA Silva, AMS Cardoso, S |
author_role |
author |
author2 |
Silva-Reis, R Ferreira, R Oliveira, PA Faustino-Rocha, AI Pinto, ML Coimbra, MA Silva, AMS Cardoso, S |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Silva, AFR Silva-Reis, R Ferreira, R Oliveira, PA Faustino-Rocha, AI Pinto, ML Coimbra, MA Silva, AMS Cardoso, S |
description |
The World Health Organization aims to stop the rise of diabetes by 2025, and diet is one of the most efficient non-pharmacological strategies used to prevent it. Resveratrol (RSV) is a natural compound with anti-diabetic properties, and incorporating it into bread is a suitable way to make it more accessible to consumers as it can be included as part of their daily diet. This study aimed to evaluate the effect of RSV-enriched bread in preventing early type 2 diabetes cardiomyopathy in vivo. Male Sprague Dawley rats (3 weeks old) were divided into four groups: controls with plain bread (CB) and RSV bread (CBR), and diabetics with plain bread (DB) and RSV bread (DBR). Type 2 diabetes was induced by adding fructose to the drinking water for two weeks followed by an injection of streptozotocin (STZ) (40 mg/kg). Then, plain bread and RSV bread (10 mg RSV/kg body weight) were included in the rats’ diet for four weeks. Cardiac function, anthropometric, and systemic biochemical parameters were monitored, as well as the histology of the heart and molecular markers of regeneration, metabolism, and oxidative stress. Data showed that an RSV bread diet decreased the polydipsia and body weight loss observed in the early stages of the disease. At the cardiac level, an RSV bread diet diminished fibrosis but did not counteract the dysfunction and metabolic changes seen in fructose-fed STZ-injected rats. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-01-01T00:00:00Z 2024-03-11T17:13:15Z 2024-03-11 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10174/36355 http://hdl.handle.net/10174/36355 |
url |
http://hdl.handle.net/10174/36355 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Silva AFR, Silva-Reis R, Ferreira R, Oliveira PA, Faustino-Rocha AI, Lurdes Pinto ML, Coimbra MA, Silva AMS, Cardoso S. 2023. The impact of resveratrol-enriched bread on cardiac remodeling in a preclinical model of diabetes. Antioxidants 12(5): 1066. Doi: 10.3390/antiox12051066. https://www.mdpi.com/2076-3921/12/5/1066 https://www.mdpi.com/2076-3921/12/5/1066 nd nd nd nd nd nd nd nd nd |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Antioxidants |
publisher.none.fl_str_mv |
Antioxidants |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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