Endothelial dysfunction – a major mediator of diabetic vascular disease
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/24558 https://doi.org/10.1016/j.bbadis.2013.08.006 |
Resumo: | The vascular endothelium is a multifunctional organ and is critically involved in modulating vascular tone and structure. Endothelial cells produce a wide range of factors that also regulate cellular adhesion, thromboresistance, smooth muscle cell proliferation, and vessel wall inflammation. Thus, endothelial function is important for the homeostasis of the body and its dysfunction is associated with several pathophysiological conditions, including atherosclerosis, hypertension and diabetes. Patients with diabetes invariably show an impairment of endothelium-dependent vasodilation. Therefore, understanding and treating endothelial dysfunction is a major focus in the prevention of vascular complications associated with all forms of diabetes mellitus. The mechanisms of endothelial dysfunction in diabetes may point to new management strategies for the prevention of cardiovascular disease in diabetes. This review will focus on the mechanisms and therapeutics that specifically target endothelial dysfunction in the context of a diabetic setting. Mechanisms including altered glucose metabolism, impaired insulin signaling, low-grade inflammatory state, and increased reactive oxygen species generation will be discussed. The importance of developing new pharmacological approaches that upregulate endothelium-derived nitric oxide synthesis and target key vascular ROS-producing enzymes will be highlighted and new strategies that might prove clinically relevant in preventing the development and/or retarding the progression of diabetes associated vascular complications. |
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Endothelial dysfunction – a major mediator of diabetic vascular diseaseEndothelial dysfunctionEndotheliumDiabetesVascular functionOxidative stressPotential therapeutic targetThe vascular endothelium is a multifunctional organ and is critically involved in modulating vascular tone and structure. Endothelial cells produce a wide range of factors that also regulate cellular adhesion, thromboresistance, smooth muscle cell proliferation, and vessel wall inflammation. Thus, endothelial function is important for the homeostasis of the body and its dysfunction is associated with several pathophysiological conditions, including atherosclerosis, hypertension and diabetes. Patients with diabetes invariably show an impairment of endothelium-dependent vasodilation. Therefore, understanding and treating endothelial dysfunction is a major focus in the prevention of vascular complications associated with all forms of diabetes mellitus. The mechanisms of endothelial dysfunction in diabetes may point to new management strategies for the prevention of cardiovascular disease in diabetes. This review will focus on the mechanisms and therapeutics that specifically target endothelial dysfunction in the context of a diabetic setting. Mechanisms including altered glucose metabolism, impaired insulin signaling, low-grade inflammatory state, and increased reactive oxygen species generation will be discussed. The importance of developing new pharmacological approaches that upregulate endothelium-derived nitric oxide synthesis and target key vascular ROS-producing enzymes will be highlighted and new strategies that might prove clinically relevant in preventing the development and/or retarding the progression of diabetes associated vascular complications.Elsevier2013-12info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/24558http://hdl.handle.net/10316/24558https://doi.org/10.1016/j.bbadis.2013.08.006engSENA, Cristina M.; PEREIRA, Ana M.; SEIÇA, Raquel - Endothelial dysfunction — A major mediator of diabetic vascular disease. "Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease". ISSN 0925-4439. Vol. 1832, nº 12 (2013) p. 2216-2231.0925-4439http://www.sciencedirect.com/science/journal/09254439Sena, Cristina M.Pereira, Ana M.Seiça, Raquelinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2020-05-25T12:17:58Zoai:estudogeral.uc.pt:10316/24558Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:53:39.628607Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Endothelial dysfunction – a major mediator of diabetic vascular disease |
title |
Endothelial dysfunction – a major mediator of diabetic vascular disease |
spellingShingle |
Endothelial dysfunction – a major mediator of diabetic vascular disease Sena, Cristina M. Endothelial dysfunction Endothelium Diabetes Vascular function Oxidative stress Potential therapeutic target |
title_short |
Endothelial dysfunction – a major mediator of diabetic vascular disease |
title_full |
Endothelial dysfunction – a major mediator of diabetic vascular disease |
title_fullStr |
Endothelial dysfunction – a major mediator of diabetic vascular disease |
title_full_unstemmed |
Endothelial dysfunction – a major mediator of diabetic vascular disease |
title_sort |
Endothelial dysfunction – a major mediator of diabetic vascular disease |
author |
Sena, Cristina M. |
author_facet |
Sena, Cristina M. Pereira, Ana M. Seiça, Raquel |
author_role |
author |
author2 |
Pereira, Ana M. Seiça, Raquel |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Sena, Cristina M. Pereira, Ana M. Seiça, Raquel |
dc.subject.por.fl_str_mv |
Endothelial dysfunction Endothelium Diabetes Vascular function Oxidative stress Potential therapeutic target |
topic |
Endothelial dysfunction Endothelium Diabetes Vascular function Oxidative stress Potential therapeutic target |
description |
The vascular endothelium is a multifunctional organ and is critically involved in modulating vascular tone and structure. Endothelial cells produce a wide range of factors that also regulate cellular adhesion, thromboresistance, smooth muscle cell proliferation, and vessel wall inflammation. Thus, endothelial function is important for the homeostasis of the body and its dysfunction is associated with several pathophysiological conditions, including atherosclerosis, hypertension and diabetes. Patients with diabetes invariably show an impairment of endothelium-dependent vasodilation. Therefore, understanding and treating endothelial dysfunction is a major focus in the prevention of vascular complications associated with all forms of diabetes mellitus. The mechanisms of endothelial dysfunction in diabetes may point to new management strategies for the prevention of cardiovascular disease in diabetes. This review will focus on the mechanisms and therapeutics that specifically target endothelial dysfunction in the context of a diabetic setting. Mechanisms including altered glucose metabolism, impaired insulin signaling, low-grade inflammatory state, and increased reactive oxygen species generation will be discussed. The importance of developing new pharmacological approaches that upregulate endothelium-derived nitric oxide synthesis and target key vascular ROS-producing enzymes will be highlighted and new strategies that might prove clinically relevant in preventing the development and/or retarding the progression of diabetes associated vascular complications. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-12 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/24558 http://hdl.handle.net/10316/24558 https://doi.org/10.1016/j.bbadis.2013.08.006 |
url |
http://hdl.handle.net/10316/24558 https://doi.org/10.1016/j.bbadis.2013.08.006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
SENA, Cristina M.; PEREIRA, Ana M.; SEIÇA, Raquel - Endothelial dysfunction — A major mediator of diabetic vascular disease. "Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease". ISSN 0925-4439. Vol. 1832, nº 12 (2013) p. 2216-2231. 0925-4439 http://www.sciencedirect.com/science/journal/09254439 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133822967611392 |