Endothelial dysfunction – a major mediator of diabetic vascular disease

Detalhes bibliográficos
Autor(a) principal: Sena, Cristina M.
Data de Publicação: 2013
Outros Autores: Pereira, Ana M., Seiça, Raquel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/24558
https://doi.org/10.1016/j.bbadis.2013.08.006
Resumo: The vascular endothelium is a multifunctional organ and is critically involved in modulating vascular tone and structure. Endothelial cells produce a wide range of factors that also regulate cellular adhesion, thromboresistance, smooth muscle cell proliferation, and vessel wall inflammation. Thus, endothelial function is important for the homeostasis of the body and its dysfunction is associated with several pathophysiological conditions, including atherosclerosis, hypertension and diabetes. Patients with diabetes invariably show an impairment of endothelium-dependent vasodilation. Therefore, understanding and treating endothelial dysfunction is a major focus in the prevention of vascular complications associated with all forms of diabetes mellitus. The mechanisms of endothelial dysfunction in diabetes may point to new management strategies for the prevention of cardiovascular disease in diabetes. This review will focus on the mechanisms and therapeutics that specifically target endothelial dysfunction in the context of a diabetic setting. Mechanisms including altered glucose metabolism, impaired insulin signaling, low-grade inflammatory state, and increased reactive oxygen species generation will be discussed. The importance of developing new pharmacological approaches that upregulate endothelium-derived nitric oxide synthesis and target key vascular ROS-producing enzymes will be highlighted and new strategies that might prove clinically relevant in preventing the development and/or retarding the progression of diabetes associated vascular complications.
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spelling Endothelial dysfunction – a major mediator of diabetic vascular diseaseEndothelial dysfunctionEndotheliumDiabetesVascular functionOxidative stressPotential therapeutic targetThe vascular endothelium is a multifunctional organ and is critically involved in modulating vascular tone and structure. Endothelial cells produce a wide range of factors that also regulate cellular adhesion, thromboresistance, smooth muscle cell proliferation, and vessel wall inflammation. Thus, endothelial function is important for the homeostasis of the body and its dysfunction is associated with several pathophysiological conditions, including atherosclerosis, hypertension and diabetes. Patients with diabetes invariably show an impairment of endothelium-dependent vasodilation. Therefore, understanding and treating endothelial dysfunction is a major focus in the prevention of vascular complications associated with all forms of diabetes mellitus. The mechanisms of endothelial dysfunction in diabetes may point to new management strategies for the prevention of cardiovascular disease in diabetes. This review will focus on the mechanisms and therapeutics that specifically target endothelial dysfunction in the context of a diabetic setting. Mechanisms including altered glucose metabolism, impaired insulin signaling, low-grade inflammatory state, and increased reactive oxygen species generation will be discussed. The importance of developing new pharmacological approaches that upregulate endothelium-derived nitric oxide synthesis and target key vascular ROS-producing enzymes will be highlighted and new strategies that might prove clinically relevant in preventing the development and/or retarding the progression of diabetes associated vascular complications.Elsevier2013-12info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/24558http://hdl.handle.net/10316/24558https://doi.org/10.1016/j.bbadis.2013.08.006engSENA, Cristina M.; PEREIRA, Ana M.; SEIÇA, Raquel - Endothelial dysfunction — A major mediator of diabetic vascular disease. "Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease". ISSN 0925-4439. Vol. 1832, nº 12 (2013) p. 2216-2231.0925-4439http://www.sciencedirect.com/science/journal/09254439Sena, Cristina M.Pereira, Ana M.Seiça, Raquelinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2020-05-25T12:17:58Zoai:estudogeral.uc.pt:10316/24558Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:53:39.628607Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Endothelial dysfunction – a major mediator of diabetic vascular disease
title Endothelial dysfunction – a major mediator of diabetic vascular disease
spellingShingle Endothelial dysfunction – a major mediator of diabetic vascular disease
Sena, Cristina M.
Endothelial dysfunction
Endothelium
Diabetes
Vascular function
Oxidative stress
Potential therapeutic target
title_short Endothelial dysfunction – a major mediator of diabetic vascular disease
title_full Endothelial dysfunction – a major mediator of diabetic vascular disease
title_fullStr Endothelial dysfunction – a major mediator of diabetic vascular disease
title_full_unstemmed Endothelial dysfunction – a major mediator of diabetic vascular disease
title_sort Endothelial dysfunction – a major mediator of diabetic vascular disease
author Sena, Cristina M.
author_facet Sena, Cristina M.
Pereira, Ana M.
Seiça, Raquel
author_role author
author2 Pereira, Ana M.
Seiça, Raquel
author2_role author
author
dc.contributor.author.fl_str_mv Sena, Cristina M.
Pereira, Ana M.
Seiça, Raquel
dc.subject.por.fl_str_mv Endothelial dysfunction
Endothelium
Diabetes
Vascular function
Oxidative stress
Potential therapeutic target
topic Endothelial dysfunction
Endothelium
Diabetes
Vascular function
Oxidative stress
Potential therapeutic target
description The vascular endothelium is a multifunctional organ and is critically involved in modulating vascular tone and structure. Endothelial cells produce a wide range of factors that also regulate cellular adhesion, thromboresistance, smooth muscle cell proliferation, and vessel wall inflammation. Thus, endothelial function is important for the homeostasis of the body and its dysfunction is associated with several pathophysiological conditions, including atherosclerosis, hypertension and diabetes. Patients with diabetes invariably show an impairment of endothelium-dependent vasodilation. Therefore, understanding and treating endothelial dysfunction is a major focus in the prevention of vascular complications associated with all forms of diabetes mellitus. The mechanisms of endothelial dysfunction in diabetes may point to new management strategies for the prevention of cardiovascular disease in diabetes. This review will focus on the mechanisms and therapeutics that specifically target endothelial dysfunction in the context of a diabetic setting. Mechanisms including altered glucose metabolism, impaired insulin signaling, low-grade inflammatory state, and increased reactive oxygen species generation will be discussed. The importance of developing new pharmacological approaches that upregulate endothelium-derived nitric oxide synthesis and target key vascular ROS-producing enzymes will be highlighted and new strategies that might prove clinically relevant in preventing the development and/or retarding the progression of diabetes associated vascular complications.
publishDate 2013
dc.date.none.fl_str_mv 2013-12
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/24558
http://hdl.handle.net/10316/24558
https://doi.org/10.1016/j.bbadis.2013.08.006
url http://hdl.handle.net/10316/24558
https://doi.org/10.1016/j.bbadis.2013.08.006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv SENA, Cristina M.; PEREIRA, Ana M.; SEIÇA, Raquel - Endothelial dysfunction — A major mediator of diabetic vascular disease. "Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease". ISSN 0925-4439. Vol. 1832, nº 12 (2013) p. 2216-2231.
0925-4439
http://www.sciencedirect.com/science/journal/09254439
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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