Marked immunosuppressive effects of the HIV-2 envelope protein in spite of the lower HIV-2 pathogenicity

Detalhes bibliográficos
Autor(a) principal: Cavaleiro, R.
Data de Publicação: 2000
Outros Autores: Sousa, A. E., Loureiro, A., Victorino, R. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/18292
Resumo: © 2000 Lippincott Williams & Wilkins
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spelling Marked immunosuppressive effects of the HIV-2 envelope protein in spite of the lower HIV-2 pathogenicityHIV-2HIV-1HIV envelope proteinsCD40LOX40© 2000 Lippincott Williams & WilkinsObjective: HIV-1 envelope proteins have immunosuppressive properties and it is thought that they have a role in the establishment of immunodeficiency. This study characterizes the immunological effects of HIV-2 envelope protein gp105, a virus which is associated with a slower rate of disease progression. Methods: The effects of recombinant baculovirus-expressed envelope proteins from HIV-IIIB HIV-1MN, HIV-2ROD and SIVmac251 on anti-CD3-stimulated peripheral blood mononuclear cells (PBMC) from healthy donors were evaluated by incorporation of 3H-thymidine, flow cytometric analysis of bromodeoxyuridine incorporation in different T cell subsets, kinetics of expression of costimulatory molecules (CD40L/OX40) and assessment of cell death by annexin V/propidium iodide staining. The effects on production of tumour necrosis factor α (TNF-α) by monocytes were assessed at the single-cell level after a 6 h culture of unstimulated PBMC. Results: HIV-2 gp105 was more inhibitory than HIV-1 gp120 of T cell proliferation and the upregulation of CD40L and OX40; in the absence of signficant induction of apoptosis. This inhibition affected both CD4 and CD8 T cells and was only partially reversed by costimulation with interleukin 2 or CD28. gp105 strongly inducted TNF-α production by monocytes. Conclusion: The immunosuppressive properties of the HIV envelope proteins could be beneficial rather than detrimental to the host by interfering with the heightened state of immunocellular activation that characterizes HIV infection and by limiting the bursts of viral replication. This hypothesis could in part explain the slower decline of CD4 cell numbers in HIV-2 infection and deserves further exploration.This study was supported by grants from Fundaçãoo para a Ciência e Tecnologia - Ministério da Ciência and from Comissão Nacional de Luta Contra a SIDA (CNLCS) - Ministério da Saúde (Portugal) to RMMV. RC, AL and AES received scholarships from Fundação para a Ciência e Tecnologia - PRAXIS XXI.Lippincott Williams &WilkinsRepositório da Universidade de LisboaCavaleiro, R.Sousa, A. E.Loureiro, A.Victorino, R. M.2015-06-17T10:09:01Z2000-122000-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/18292engAIDS 2000, 14: 2679-26860269-9370http://journals.lww.com/aidsonline/Fulltext/2000/12010/Marked_immunosuppressive_effects_of_the_HIV_2.7.aspxmetadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:04:29Zoai:repositorio.ul.pt:10451/18292Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:37:53.276378Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Marked immunosuppressive effects of the HIV-2 envelope protein in spite of the lower HIV-2 pathogenicity
title Marked immunosuppressive effects of the HIV-2 envelope protein in spite of the lower HIV-2 pathogenicity
spellingShingle Marked immunosuppressive effects of the HIV-2 envelope protein in spite of the lower HIV-2 pathogenicity
Cavaleiro, R.
HIV-2
HIV-1
HIV envelope proteins
CD40L
OX40
title_short Marked immunosuppressive effects of the HIV-2 envelope protein in spite of the lower HIV-2 pathogenicity
title_full Marked immunosuppressive effects of the HIV-2 envelope protein in spite of the lower HIV-2 pathogenicity
title_fullStr Marked immunosuppressive effects of the HIV-2 envelope protein in spite of the lower HIV-2 pathogenicity
title_full_unstemmed Marked immunosuppressive effects of the HIV-2 envelope protein in spite of the lower HIV-2 pathogenicity
title_sort Marked immunosuppressive effects of the HIV-2 envelope protein in spite of the lower HIV-2 pathogenicity
author Cavaleiro, R.
author_facet Cavaleiro, R.
Sousa, A. E.
Loureiro, A.
Victorino, R. M.
author_role author
author2 Sousa, A. E.
Loureiro, A.
Victorino, R. M.
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Cavaleiro, R.
Sousa, A. E.
Loureiro, A.
Victorino, R. M.
dc.subject.por.fl_str_mv HIV-2
HIV-1
HIV envelope proteins
CD40L
OX40
topic HIV-2
HIV-1
HIV envelope proteins
CD40L
OX40
description © 2000 Lippincott Williams & Wilkins
publishDate 2000
dc.date.none.fl_str_mv 2000-12
2000-12-01T00:00:00Z
2015-06-17T10:09:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/18292
url http://hdl.handle.net/10451/18292
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv AIDS 2000, 14: 2679-2686
0269-9370
http://journals.lww.com/aidsonline/Fulltext/2000/12010/Marked_immunosuppressive_effects_of_the_HIV_2.7.aspx
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams &Wilkins
publisher.none.fl_str_mv Lippincott Williams &Wilkins
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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