Factors associated with COVID-19-related death in people with rheumatic diseases : results from the COVID-19 Global Rheumatology Alliance physician-reported registry
| Autor(a) principal: | |
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| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/46633 |
Resumo: | © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
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Factors associated with COVID-19-related death in people with rheumatic diseases : results from the COVID-19 Global Rheumatology Alliance physician-reported registryAntirheumatic agentsAutoimmune diseasesEpidemiologyGlucocorticoidsHealth careOutcome assessment© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.Objectives: To determine factors associated with COVID-19-related death in people with rheumatic diseases. Methods: Physician-reported registry of adults with rheumatic disease and confirmed or presumptive COVID-19 (from 24 March to 1 July 2020). The primary outcome was COVID-19-related death. Age, sex, smoking status, comorbidities, rheumatic disease diagnosis, disease activity and medications were included as covariates in multivariable logistic regression models. Analyses were further stratified according to rheumatic disease category. Results: Of 3729 patients (mean age 57 years, 68% female), 390 (10.5%) died. Independent factors associated with COVID-19-related death were age (66-75 years: OR 3.00, 95% CI 2.13 to 4.22; >75 years: 6.18, 4.47 to 8.53; both vs ≤65 years), male sex (1.46, 1.11 to 1.91), hypertension combined with cardiovascular disease (1.89, 1.31 to 2.73), chronic lung disease (1.68, 1.26 to 2.25) and prednisolone-equivalent dosage >10 mg/day (1.69, 1.18 to 2.41; vs no glucocorticoid intake). Moderate/high disease activity (vs remission/low disease activity) was associated with higher odds of death (1.87, 1.27 to 2.77). Rituximab (4.04, 2.32 to 7.03), sulfasalazine (3.60, 1.66 to 7.78), immunosuppressants (azathioprine, cyclophosphamide, ciclosporin, mycophenolate or tacrolimus: 2.22, 1.43 to 3.46) and not receiving any disease-modifying anti-rheumatic drug (DMARD) (2.11, 1.48 to 3.01) were associated with higher odds of death, compared with methotrexate monotherapy. Other synthetic/biological DMARDs were not associated with COVID-19-related death. Conclusion: Among people with rheumatic disease, COVID-19-related death was associated with known general factors (older age, male sex and specific comorbidities) and disease-specific factors (disease activity and specific medications). The association with moderate/high disease activity highlights the importance of adequate disease control with DMARDs, preferably without increasing glucocorticoid dosages. Caution may be required with rituximab, sulfasalazine and some immunosuppressants.BMJ Publishing Group Ltd.Repositório da Universidade de LisboaStrangfeld, AnjaSchäfer, MartinGianfrancesco, Milena A.Lawson-Tovey, SaskiaLiew, Jean W.Ljung, LottaMateus, Elsa F.Richez, ChristopheSantos, MariaSchmajuk, GabrielaScirè, Carlo A.Sirotich, EmilySparks, Jeffrey A.Sufka, PaulThomas, ThierryTrupin, LauraWallace, Zachary S.Al-Adely, SarahBachiller-Corral, JavierBhana, SulemanCacoub, PatriceCarmona, LoretoCostello, RuthCostello, WendyGossec, LaureGrainger, RebeccaHachulla, EricHasseli, RebeccaHausmann, Jonathan S.Hyrich, Kimme L.Izadi, ZaraJacobsohn, LindsayKatz, PatriciaKearsley-Fleet, LianneRobinson, Philip C.Yazdany, JinoosMachado, Pedro2021-03-03T18:01:56Z2021-01-272021-01-27T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/46633engAnn Rheum Dis. 2021 Jan 270003-496710.1136/annrheumdis-2020-2194981468-2060info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:49:03Zoai:repositorio.ul.pt:10451/46633Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:58:46.724308Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Factors associated with COVID-19-related death in people with rheumatic diseases : results from the COVID-19 Global Rheumatology Alliance physician-reported registry |
| title |
Factors associated with COVID-19-related death in people with rheumatic diseases : results from the COVID-19 Global Rheumatology Alliance physician-reported registry |
| spellingShingle |
Factors associated with COVID-19-related death in people with rheumatic diseases : results from the COVID-19 Global Rheumatology Alliance physician-reported registry Strangfeld, Anja Antirheumatic agents Autoimmune diseases Epidemiology Glucocorticoids Health care Outcome assessment |
| title_short |
Factors associated with COVID-19-related death in people with rheumatic diseases : results from the COVID-19 Global Rheumatology Alliance physician-reported registry |
| title_full |
Factors associated with COVID-19-related death in people with rheumatic diseases : results from the COVID-19 Global Rheumatology Alliance physician-reported registry |
| title_fullStr |
Factors associated with COVID-19-related death in people with rheumatic diseases : results from the COVID-19 Global Rheumatology Alliance physician-reported registry |
| title_full_unstemmed |
Factors associated with COVID-19-related death in people with rheumatic diseases : results from the COVID-19 Global Rheumatology Alliance physician-reported registry |
| title_sort |
Factors associated with COVID-19-related death in people with rheumatic diseases : results from the COVID-19 Global Rheumatology Alliance physician-reported registry |
| author |
Strangfeld, Anja |
| author_facet |
Strangfeld, Anja Schäfer, Martin Gianfrancesco, Milena A. Lawson-Tovey, Saskia Liew, Jean W. Ljung, Lotta Mateus, Elsa F. Richez, Christophe Santos, Maria Schmajuk, Gabriela Scirè, Carlo A. Sirotich, Emily Sparks, Jeffrey A. Sufka, Paul Thomas, Thierry Trupin, Laura Wallace, Zachary S. Al-Adely, Sarah Bachiller-Corral, Javier Bhana, Suleman Cacoub, Patrice Carmona, Loreto Costello, Ruth Costello, Wendy Gossec, Laure Grainger, Rebecca Hachulla, Eric Hasseli, Rebecca Hausmann, Jonathan S. Hyrich, Kimme L. Izadi, Zara Jacobsohn, Lindsay Katz, Patricia Kearsley-Fleet, Lianne Robinson, Philip C. Yazdany, Jinoos Machado, Pedro |
| author_role |
author |
| author2 |
Schäfer, Martin Gianfrancesco, Milena A. Lawson-Tovey, Saskia Liew, Jean W. Ljung, Lotta Mateus, Elsa F. Richez, Christophe Santos, Maria Schmajuk, Gabriela Scirè, Carlo A. Sirotich, Emily Sparks, Jeffrey A. Sufka, Paul Thomas, Thierry Trupin, Laura Wallace, Zachary S. Al-Adely, Sarah Bachiller-Corral, Javier Bhana, Suleman Cacoub, Patrice Carmona, Loreto Costello, Ruth Costello, Wendy Gossec, Laure Grainger, Rebecca Hachulla, Eric Hasseli, Rebecca Hausmann, Jonathan S. Hyrich, Kimme L. Izadi, Zara Jacobsohn, Lindsay Katz, Patricia Kearsley-Fleet, Lianne Robinson, Philip C. Yazdany, Jinoos Machado, Pedro |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Strangfeld, Anja Schäfer, Martin Gianfrancesco, Milena A. Lawson-Tovey, Saskia Liew, Jean W. Ljung, Lotta Mateus, Elsa F. Richez, Christophe Santos, Maria Schmajuk, Gabriela Scirè, Carlo A. Sirotich, Emily Sparks, Jeffrey A. Sufka, Paul Thomas, Thierry Trupin, Laura Wallace, Zachary S. Al-Adely, Sarah Bachiller-Corral, Javier Bhana, Suleman Cacoub, Patrice Carmona, Loreto Costello, Ruth Costello, Wendy Gossec, Laure Grainger, Rebecca Hachulla, Eric Hasseli, Rebecca Hausmann, Jonathan S. Hyrich, Kimme L. Izadi, Zara Jacobsohn, Lindsay Katz, Patricia Kearsley-Fleet, Lianne Robinson, Philip C. Yazdany, Jinoos Machado, Pedro |
| dc.subject.por.fl_str_mv |
Antirheumatic agents Autoimmune diseases Epidemiology Glucocorticoids Health care Outcome assessment |
| topic |
Antirheumatic agents Autoimmune diseases Epidemiology Glucocorticoids Health care Outcome assessment |
| description |
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-03-03T18:01:56Z 2021-01-27 2021-01-27T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10451/46633 |
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http://hdl.handle.net/10451/46633 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
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Ann Rheum Dis. 2021 Jan 27 0003-4967 10.1136/annrheumdis-2020-219498 1468-2060 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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BMJ Publishing Group Ltd. |
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BMJ Publishing Group Ltd. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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