Histopathology of psoriatic arthritis synovium: a narrative review

Detalhes bibliográficos
Autor(a) principal: Tenazinha, Catarina
Data de Publicação: 2022
Outros Autores: Barros, Rita, Fonseca, João Eurico, Vieira De Sousa, Elsa Cristina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/58077
Resumo: Copyright © 2022 Tenazinha, Barros, Fonseca and Vieira-Sousa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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spelling Histopathology of psoriatic arthritis synovium: a narrative reviewHistopathologyInflammatory arthritisPsoriatic arthritis (PsA)SpondyloarthropathySynovial membrane (SM);SynovitisSynoviumCopyright © 2022 Tenazinha, Barros, Fonseca and Vieira-Sousa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Psoriatic arthritis (PsA) is a phenotypically heterogeneous chronic inflammatory disease associated to type I major histocompatibility complex alleles whose complex pathogenesis is still not completely understood. The psoriatic synovium shares general features of chronic inflammation with rheumatoid arthritis (RA) and other arthritis, such as hyperplasia of the intimal lining layer, sublining influx of inflammatory cells and neoangiogenesis, but recognizing disease-specific histopathologic findings may help in diagnosis and definition of therapeutic targets. Available literature reports conflicting data regarding the extension of lining hyperplasia, that does not allow depiction from RA. Sublining inflammatory cells consist of T and B cells and macrophages, plasma cells, mast cells and follicular dendritic cells, with a higher amount of overall T, mast cell and IL-17 producing CD8+ T lymphocytes and lower proportion of plasma cells when compared to the rheumatoid synovium. The amount of synovium IL17+ CD8+ T cells correlates positively to measures of disease activity. Lymphoid follicles with characteristics of germinal centers have been identified, similar to the ones described in RA. Neoangiogenesis is more prominent in PsA but can also be an outstanding feature in some RA samples, and different molecules involved in the process appear to have different influence in each disease. IL-17 and IL-22 expression in the synovium does not allow depiction between diseases. Among other cytokines and molecules likely implicated in disease physiopathology, only IL-35 is demonstrated to be reduced in PsA when compared to RA.FrontiersRepositório da Universidade de LisboaTenazinha, CatarinaBarros, RitaFonseca, João EuricoVieira De Sousa, Elsa Cristina2023-06-07T14:33:21Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/58077engFront Med (Lausanne). 2022 Jul 1;9:86081310.3389/fmed.2022.8608132296-858Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:06:43Zoai:repositorio.ul.pt:10451/58077Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:08:21.867460Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Histopathology of psoriatic arthritis synovium: a narrative review
title Histopathology of psoriatic arthritis synovium: a narrative review
spellingShingle Histopathology of psoriatic arthritis synovium: a narrative review
Tenazinha, Catarina
Histopathology
Inflammatory arthritis
Psoriatic arthritis (PsA)
Spondyloarthropathy
Synovial membrane (SM);
Synovitis
Synovium
title_short Histopathology of psoriatic arthritis synovium: a narrative review
title_full Histopathology of psoriatic arthritis synovium: a narrative review
title_fullStr Histopathology of psoriatic arthritis synovium: a narrative review
title_full_unstemmed Histopathology of psoriatic arthritis synovium: a narrative review
title_sort Histopathology of psoriatic arthritis synovium: a narrative review
author Tenazinha, Catarina
author_facet Tenazinha, Catarina
Barros, Rita
Fonseca, João Eurico
Vieira De Sousa, Elsa Cristina
author_role author
author2 Barros, Rita
Fonseca, João Eurico
Vieira De Sousa, Elsa Cristina
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Tenazinha, Catarina
Barros, Rita
Fonseca, João Eurico
Vieira De Sousa, Elsa Cristina
dc.subject.por.fl_str_mv Histopathology
Inflammatory arthritis
Psoriatic arthritis (PsA)
Spondyloarthropathy
Synovial membrane (SM);
Synovitis
Synovium
topic Histopathology
Inflammatory arthritis
Psoriatic arthritis (PsA)
Spondyloarthropathy
Synovial membrane (SM);
Synovitis
Synovium
description Copyright © 2022 Tenazinha, Barros, Fonseca and Vieira-Sousa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-01T00:00:00Z
2023-06-07T14:33:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/58077
url http://hdl.handle.net/10451/58077
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Front Med (Lausanne). 2022 Jul 1;9:860813
10.3389/fmed.2022.860813
2296-858X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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