The Evaluation of QT Intervals During Diagnosis and After Follow-Up in Acromegaly Patients
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4966 |
Resumo: | Introduction: It was aimed to calculate QT intervals in patients with acromegaly and to reveal its correlation between QT intervals, and growth hormone and insulin like growth factor-1.Material and Methods: Forty-one patients with acromegaly were enrolled into the study. Another 41 individuals with similar features, such as comorbid diseases, age and sex constituted the control group. The electrocardiographies of patients with acromegaly were evaluated at the baseline and after the follow- up. Only one electrocardiography was performed for controls. QT maximum, QT minimum, QT dispersion, corrected QT maximum, corrected QT minimum and corrected QT dispersion were calculated.Results: Baseline QT maximum, QT dispersion, corrected QT maximum and corrected QT dispersion were significantly longer than the values of controls. Corrected QT maximum and corrected QT dispersion were significantly shorter after the follow-up, compared to the baseline in patients. QT maximum, QT dispersion, corrected QT maximum and corrected QT dispersion after the follow-up were not statistically different from the values of controls. Except the negative correlation between growth hormone and corrected QT dispersion in patients after the follow-up, no other correlation was detected between QT values and growth hormone or insulin like growth factor-1 levels. Corrected QT dispersion was found to be related with the disease duration in patients.Discussion: For acromegaly patients, it is important to detect clinical predictors of cardiac arrhytmias. QT dispersion is considered a beneficial predictor for ventricular arrhytmias. When compared to controls, prolonged QT intervals were determined in our acromegalic patients.Conclusion: We consider that QT intervals may also be utilized in the evaluation of increased cardiovascular risk in patients withacromegaly.Keywords: Acromegaly; Arrhythmias, Cardiac; Electrocardiography; Heart Rate. |
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The Evaluation of QT Intervals During Diagnosis and After Follow-Up in Acromegaly PatientsAvaliação do Intervalo QT no Momento do Diagnóstico e Durante o Seguimento Clínico em Doentes com AcromegáliaIntroduction: It was aimed to calculate QT intervals in patients with acromegaly and to reveal its correlation between QT intervals, and growth hormone and insulin like growth factor-1.Material and Methods: Forty-one patients with acromegaly were enrolled into the study. Another 41 individuals with similar features, such as comorbid diseases, age and sex constituted the control group. The electrocardiographies of patients with acromegaly were evaluated at the baseline and after the follow- up. Only one electrocardiography was performed for controls. QT maximum, QT minimum, QT dispersion, corrected QT maximum, corrected QT minimum and corrected QT dispersion were calculated.Results: Baseline QT maximum, QT dispersion, corrected QT maximum and corrected QT dispersion were significantly longer than the values of controls. Corrected QT maximum and corrected QT dispersion were significantly shorter after the follow-up, compared to the baseline in patients. QT maximum, QT dispersion, corrected QT maximum and corrected QT dispersion after the follow-up were not statistically different from the values of controls. Except the negative correlation between growth hormone and corrected QT dispersion in patients after the follow-up, no other correlation was detected between QT values and growth hormone or insulin like growth factor-1 levels. Corrected QT dispersion was found to be related with the disease duration in patients.Discussion: For acromegaly patients, it is important to detect clinical predictors of cardiac arrhytmias. QT dispersion is considered a beneficial predictor for ventricular arrhytmias. When compared to controls, prolonged QT intervals were determined in our acromegalic patients.Conclusion: We consider that QT intervals may also be utilized in the evaluation of increased cardiovascular risk in patients withacromegaly.Keywords: Acromegaly; Arrhythmias, Cardiac; Electrocardiography; Heart Rate.Introdução: O estudo teve como objectivo a determinação do intervalo QT em doentes com acromegália e a análise da correlação entre o intervalo QT e a concentração de hormona do crescimento e de IGF-1 (insulin-like growth factor-1).Material e Métodos: O estudo englobou 41 doentes com acromegália. O grupo de controlo englobou 41 indivíduos com características semelhantes no que se refere a comorbilidades, idade e género. A electrocardiografia de doentes com acromegália foi obtida no início do estudo e após o follow-up. Foi apenas obtido um electrocardiograma no grupo de controlo. Foram calculados o QT máximo, QT mínimo, dispersão do intervalo QT, QT máximo corrigido, QT mínimo corrigido e dispersão do intervalo QT corrigido.Resultados: Os valores do QT máximo basal, dispersão do intervalo QT, QT máximo corrigido e dispersão do QT corrigido foram significativamente mais prolongados no grupo de doentes com acromegália do que nos controlos. O QT máximo corrigido e a dispersão do QT corrigido foram significativamente mais curtos durante o seguimento clínico, quando comparados com os valores basais dos doentes. O QT máximo, dispersão do QT, QT máximo corrigido e dispersão do QT corrigido durante o seguimento clínico não foram estatisticamente diferentes dos valores obtidos nos controlos. Com excepção de uma correlação negativa entre os valores da hormona do crescimento e a dispersão do QT corrigido em doentes durante o seguimento clínico, nenhuma outra correlação foi assinalada entre os valores do intervalo QT e as concentrações de hormona do crescimento e de IGF-1. Concluiu-se que a dispersão do intervalo QT está correlacionada com a duração da doença nos doentes com acromegália.Discussão: Em doentes com acromegália, é importante a detecção de preditores clínicos de arritmia cardíaca. A dispersão do intervalo QT é considerada um preditor relevante de arritmias ventriculares. Os doentes com acromegália englobados no nosso estudo apresentaram intervalos QT prolongados, quando comparados com os controlos.Conclusão: A avaliação do risco cardiovascular em doentes com acromegália deve englobar a determinação do intervalo QT.Palavras-chave: Acromegalia; Arritmias Cardiacas; Electrocardiografia; Frequência Cardíaca.Ordem dos Médicos2014-08-29info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/mswordapplication/mswordapplication/mswordapplication/mswordhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4966oai:ojs.www.actamedicaportuguesa.com:article/4966Acta Médica Portuguesa; Vol. 27 No. 4 (2014): July-August; 428-432Acta Médica Portuguesa; Vol. 27 N.º 4 (2014): Julho-Agosto; 428-4321646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4966https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4966/4016https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4966/7026https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4966/7027https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4966/7028https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4966/7029Baser, HusniyeAkar Bayram, NihalPolat, BurcakEvranos, BernaErsoy, ReyhanBozkurt, EnginCakir, Bekirinfo:eu-repo/semantics/openAccess2022-12-20T11:04:07Zoai:ojs.www.actamedicaportuguesa.com:article/4966Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:19:00.820668Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The Evaluation of QT Intervals During Diagnosis and After Follow-Up in Acromegaly Patients Avaliação do Intervalo QT no Momento do Diagnóstico e Durante o Seguimento Clínico em Doentes com Acromegália |
title |
The Evaluation of QT Intervals During Diagnosis and After Follow-Up in Acromegaly Patients |
spellingShingle |
The Evaluation of QT Intervals During Diagnosis and After Follow-Up in Acromegaly Patients Baser, Husniye |
title_short |
The Evaluation of QT Intervals During Diagnosis and After Follow-Up in Acromegaly Patients |
title_full |
The Evaluation of QT Intervals During Diagnosis and After Follow-Up in Acromegaly Patients |
title_fullStr |
The Evaluation of QT Intervals During Diagnosis and After Follow-Up in Acromegaly Patients |
title_full_unstemmed |
The Evaluation of QT Intervals During Diagnosis and After Follow-Up in Acromegaly Patients |
title_sort |
The Evaluation of QT Intervals During Diagnosis and After Follow-Up in Acromegaly Patients |
author |
Baser, Husniye |
author_facet |
Baser, Husniye Akar Bayram, Nihal Polat, Burcak Evranos, Berna Ersoy, Reyhan Bozkurt, Engin Cakir, Bekir |
author_role |
author |
author2 |
Akar Bayram, Nihal Polat, Burcak Evranos, Berna Ersoy, Reyhan Bozkurt, Engin Cakir, Bekir |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Baser, Husniye Akar Bayram, Nihal Polat, Burcak Evranos, Berna Ersoy, Reyhan Bozkurt, Engin Cakir, Bekir |
description |
Introduction: It was aimed to calculate QT intervals in patients with acromegaly and to reveal its correlation between QT intervals, and growth hormone and insulin like growth factor-1.Material and Methods: Forty-one patients with acromegaly were enrolled into the study. Another 41 individuals with similar features, such as comorbid diseases, age and sex constituted the control group. The electrocardiographies of patients with acromegaly were evaluated at the baseline and after the follow- up. Only one electrocardiography was performed for controls. QT maximum, QT minimum, QT dispersion, corrected QT maximum, corrected QT minimum and corrected QT dispersion were calculated.Results: Baseline QT maximum, QT dispersion, corrected QT maximum and corrected QT dispersion were significantly longer than the values of controls. Corrected QT maximum and corrected QT dispersion were significantly shorter after the follow-up, compared to the baseline in patients. QT maximum, QT dispersion, corrected QT maximum and corrected QT dispersion after the follow-up were not statistically different from the values of controls. Except the negative correlation between growth hormone and corrected QT dispersion in patients after the follow-up, no other correlation was detected between QT values and growth hormone or insulin like growth factor-1 levels. Corrected QT dispersion was found to be related with the disease duration in patients.Discussion: For acromegaly patients, it is important to detect clinical predictors of cardiac arrhytmias. QT dispersion is considered a beneficial predictor for ventricular arrhytmias. When compared to controls, prolonged QT intervals were determined in our acromegalic patients.Conclusion: We consider that QT intervals may also be utilized in the evaluation of increased cardiovascular risk in patients withacromegaly.Keywords: Acromegaly; Arrhythmias, Cardiac; Electrocardiography; Heart Rate. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-08-29 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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publishedVersion |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4966 oai:ojs.www.actamedicaportuguesa.com:article/4966 |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4966 |
identifier_str_mv |
oai:ojs.www.actamedicaportuguesa.com:article/4966 |
dc.language.iso.fl_str_mv |
eng |
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eng |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4966 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4966/4016 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4966/7026 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4966/7027 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4966/7028 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4966/7029 |
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openAccess |
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dc.publisher.none.fl_str_mv |
Ordem dos Médicos |
publisher.none.fl_str_mv |
Ordem dos Médicos |
dc.source.none.fl_str_mv |
Acta Médica Portuguesa; Vol. 27 No. 4 (2014): July-August; 428-432 Acta Médica Portuguesa; Vol. 27 N.º 4 (2014): Julho-Agosto; 428-432 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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