Angiotensin I-converting enzyme (ACE) inhibitory activity of Fucus spiralis macroalgae and influence of the extracts storage temperature : A short report
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Data de Publicação: | 2016 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.3/6240 |
Resumo: | 16th Latin-American Congress on Chromatography (COLACRO) / 9th National Meeting on Chromatography (ENC), Lisbon, PORTUGAL, JAN 05-09, 2016. |
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Angiotensin I-converting enzyme (ACE) inhibitory activity of Fucus spiralis macroalgae and influence of the extracts storage temperature : A short reportACE-inhibitory ActivityHPLCHypertensionPhlorotanninsSample Stability StudiesTotal Phenolic Content16th Latin-American Congress on Chromatography (COLACRO) / 9th National Meeting on Chromatography (ENC), Lisbon, PORTUGAL, JAN 05-09, 2016.Recently, increasing attention has been paid to the marine algae as a natural source of novel angiotensin-I converting enzyme (ACE) inhibitors, such as the phlorotannins that are the predominant polyphenols in brown algae. This study reports, for the first time, the ACE inhibition of methanol extract/fractions from Azorean brown algae Fucus spiralis (Fs) determined by HPLC-UV method, their total phenolic content (TPC) quantified as phloroglucinol equivalents (PE) and the effect of the Fs dry powder methanol extracts (Fs-DME) storage temperature on ACE inhibition. The results indicate that the ACE inhibition of Fs-DME decreased by 28.8% and 78.2% when stored during 15 days at −80 ◦C and −13 ◦C, respectively, as compared with the activity of Fs-DME at a refrigerated temperature of 6 ◦C and assayed immediately after extraction that showed a value of 80.1 ± 2.1%. This Fs-DME sample was fractionated by ultrafiltration membranes into three molecular weight ranges (3 kDa), presenting the fraction >3 kDa remarkably high ACE inhibition (88.8 ± 2.4%), TPC value (156.6 ± 1.4 mg PE/g of dry weight fraction) and yield. Furthermore, chromatographic and spectrophotometric analyses corroborate that phenolic compounds were present in Fs methanol extract/fractions, and also revealed that phloroglucinol occurs in Fs. The results seem to suggest that Azorean Fs can be a source of powerful ACE-inhibitory phlorotannins with potential impact on public health, particularly on hypertensive patients.This study was financially supported by cE3c funding (Ref: UID/BIA/00329/2013). Lisete Paiva was supported by a doctoral grant (Ref: M3.1.2/F/014/2011) awarded by FRC (Fundo Regional da Ciência).ElsevierRepositório da Universidade dos AçoresPaiva, Lisete S.Lima, ElisabeteNeto, Ana I.Baptista, José2022-03-11T11:59:42Z2016-112022-01-28T17:54:38Z2016-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.3/6240engPaiva, L., Lima, E., Baptista, J., & Neto, A.I.. (2016). Angiotensin I-converting enzyme (ACE) inhibitory activity of Fucus spiralis macroalgae and influence of the extracts storage temperature - A short report. “Journal of Pharmaceutical and Biomedical Analysis”, 131, 503–507. https://doi.org/10.1016/j.jpba.2016.08.0290731-7085cv-prod-268710210.1016/j.jpba.2016.08.0291873-264X27595387000387628400062metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-12-20T14:34:35Zoai:repositorio.uac.pt:10400.3/6240Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:28:19.094298Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Angiotensin I-converting enzyme (ACE) inhibitory activity of Fucus spiralis macroalgae and influence of the extracts storage temperature : A short report |
title |
Angiotensin I-converting enzyme (ACE) inhibitory activity of Fucus spiralis macroalgae and influence of the extracts storage temperature : A short report |
spellingShingle |
Angiotensin I-converting enzyme (ACE) inhibitory activity of Fucus spiralis macroalgae and influence of the extracts storage temperature : A short report Paiva, Lisete S. ACE-inhibitory Activity HPLC Hypertension Phlorotannins Sample Stability Studies Total Phenolic Content |
title_short |
Angiotensin I-converting enzyme (ACE) inhibitory activity of Fucus spiralis macroalgae and influence of the extracts storage temperature : A short report |
title_full |
Angiotensin I-converting enzyme (ACE) inhibitory activity of Fucus spiralis macroalgae and influence of the extracts storage temperature : A short report |
title_fullStr |
Angiotensin I-converting enzyme (ACE) inhibitory activity of Fucus spiralis macroalgae and influence of the extracts storage temperature : A short report |
title_full_unstemmed |
Angiotensin I-converting enzyme (ACE) inhibitory activity of Fucus spiralis macroalgae and influence of the extracts storage temperature : A short report |
title_sort |
Angiotensin I-converting enzyme (ACE) inhibitory activity of Fucus spiralis macroalgae and influence of the extracts storage temperature : A short report |
author |
Paiva, Lisete S. |
author_facet |
Paiva, Lisete S. Lima, Elisabete Neto, Ana I. Baptista, José |
author_role |
author |
author2 |
Lima, Elisabete Neto, Ana I. Baptista, José |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade dos Açores |
dc.contributor.author.fl_str_mv |
Paiva, Lisete S. Lima, Elisabete Neto, Ana I. Baptista, José |
dc.subject.por.fl_str_mv |
ACE-inhibitory Activity HPLC Hypertension Phlorotannins Sample Stability Studies Total Phenolic Content |
topic |
ACE-inhibitory Activity HPLC Hypertension Phlorotannins Sample Stability Studies Total Phenolic Content |
description |
16th Latin-American Congress on Chromatography (COLACRO) / 9th National Meeting on Chromatography (ENC), Lisbon, PORTUGAL, JAN 05-09, 2016. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-11 2016-11-01T00:00:00Z 2022-03-11T11:59:42Z 2022-01-28T17:54:38Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.3/6240 |
url |
http://hdl.handle.net/10400.3/6240 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Paiva, L., Lima, E., Baptista, J., & Neto, A.I.. (2016). Angiotensin I-converting enzyme (ACE) inhibitory activity of Fucus spiralis macroalgae and influence of the extracts storage temperature - A short report. “Journal of Pharmaceutical and Biomedical Analysis”, 131, 503–507. https://doi.org/10.1016/j.jpba.2016.08.029 0731-7085 cv-prod-2687102 10.1016/j.jpba.2016.08.029 1873-264X 27595387 000387628400062 |
dc.rights.driver.fl_str_mv |
metadata only access info:eu-repo/semantics/openAccess |
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metadata only access |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1817551462537887744 |