Angiotensin I-converting enzyme (ACE) inhibitory activity of Fucus spiralis macroalgae and influence of the extracts storage temperature : A short report

Detalhes bibliográficos
Autor(a) principal: Paiva, Lisete S.
Data de Publicação: 2016
Outros Autores: Lima, Elisabete, Neto, Ana I., Baptista, José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.3/6240
Resumo: 16th Latin-American Congress on Chromatography (COLACRO) / 9th National Meeting on Chromatography (ENC), Lisbon, PORTUGAL, JAN 05-09, 2016.
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spelling Angiotensin I-converting enzyme (ACE) inhibitory activity of Fucus spiralis macroalgae and influence of the extracts storage temperature : A short reportACE-inhibitory ActivityHPLCHypertensionPhlorotanninsSample Stability StudiesTotal Phenolic Content16th Latin-American Congress on Chromatography (COLACRO) / 9th National Meeting on Chromatography (ENC), Lisbon, PORTUGAL, JAN 05-09, 2016.Recently, increasing attention has been paid to the marine algae as a natural source of novel angiotensin-I converting enzyme (ACE) inhibitors, such as the phlorotannins that are the predominant polyphenols in brown algae. This study reports, for the first time, the ACE inhibition of methanol extract/fractions from Azorean brown algae Fucus spiralis (Fs) determined by HPLC-UV method, their total phenolic content (TPC) quantified as phloroglucinol equivalents (PE) and the effect of the Fs dry powder methanol extracts (Fs-DME) storage temperature on ACE inhibition. The results indicate that the ACE inhibition of Fs-DME decreased by 28.8% and 78.2% when stored during 15 days at −80 ◦C and −13 ◦C, respectively, as compared with the activity of Fs-DME at a refrigerated temperature of 6 ◦C and assayed immediately after extraction that showed a value of 80.1 ± 2.1%. This Fs-DME sample was fractionated by ultrafiltration membranes into three molecular weight ranges (3 kDa), presenting the fraction >3 kDa remarkably high ACE inhibition (88.8 ± 2.4%), TPC value (156.6 ± 1.4 mg PE/g of dry weight fraction) and yield. Furthermore, chromatographic and spectrophotometric analyses corroborate that phenolic compounds were present in Fs methanol extract/fractions, and also revealed that phloroglucinol occurs in Fs. The results seem to suggest that Azorean Fs can be a source of powerful ACE-inhibitory phlorotannins with potential impact on public health, particularly on hypertensive patients.This study was financially supported by cE3c funding (Ref: UID/BIA/00329/2013). Lisete Paiva was supported by a doctoral grant (Ref: M3.1.2/F/014/2011) awarded by FRC (Fundo Regional da Ciência).ElsevierRepositório da Universidade dos AçoresPaiva, Lisete S.Lima, ElisabeteNeto, Ana I.Baptista, José2022-03-11T11:59:42Z2016-112022-01-28T17:54:38Z2016-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.3/6240engPaiva, L., Lima, E., Baptista, J., & Neto, A.I.. (2016). Angiotensin I-converting enzyme (ACE) inhibitory activity of Fucus spiralis macroalgae and influence of the extracts storage temperature - A short report. “Journal of Pharmaceutical and Biomedical Analysis”, 131, 503–507. https://doi.org/10.1016/j.jpba.2016.08.0290731-7085cv-prod-268710210.1016/j.jpba.2016.08.0291873-264X27595387000387628400062metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-12-20T14:34:35Zoai:repositorio.uac.pt:10400.3/6240Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:28:19.094298Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Angiotensin I-converting enzyme (ACE) inhibitory activity of Fucus spiralis macroalgae and influence of the extracts storage temperature : A short report
title Angiotensin I-converting enzyme (ACE) inhibitory activity of Fucus spiralis macroalgae and influence of the extracts storage temperature : A short report
spellingShingle Angiotensin I-converting enzyme (ACE) inhibitory activity of Fucus spiralis macroalgae and influence of the extracts storage temperature : A short report
Paiva, Lisete S.
ACE-inhibitory Activity
HPLC
Hypertension
Phlorotannins
Sample Stability Studies
Total Phenolic Content
title_short Angiotensin I-converting enzyme (ACE) inhibitory activity of Fucus spiralis macroalgae and influence of the extracts storage temperature : A short report
title_full Angiotensin I-converting enzyme (ACE) inhibitory activity of Fucus spiralis macroalgae and influence of the extracts storage temperature : A short report
title_fullStr Angiotensin I-converting enzyme (ACE) inhibitory activity of Fucus spiralis macroalgae and influence of the extracts storage temperature : A short report
title_full_unstemmed Angiotensin I-converting enzyme (ACE) inhibitory activity of Fucus spiralis macroalgae and influence of the extracts storage temperature : A short report
title_sort Angiotensin I-converting enzyme (ACE) inhibitory activity of Fucus spiralis macroalgae and influence of the extracts storage temperature : A short report
author Paiva, Lisete S.
author_facet Paiva, Lisete S.
Lima, Elisabete
Neto, Ana I.
Baptista, José
author_role author
author2 Lima, Elisabete
Neto, Ana I.
Baptista, José
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade dos Açores
dc.contributor.author.fl_str_mv Paiva, Lisete S.
Lima, Elisabete
Neto, Ana I.
Baptista, José
dc.subject.por.fl_str_mv ACE-inhibitory Activity
HPLC
Hypertension
Phlorotannins
Sample Stability Studies
Total Phenolic Content
topic ACE-inhibitory Activity
HPLC
Hypertension
Phlorotannins
Sample Stability Studies
Total Phenolic Content
description 16th Latin-American Congress on Chromatography (COLACRO) / 9th National Meeting on Chromatography (ENC), Lisbon, PORTUGAL, JAN 05-09, 2016.
publishDate 2016
dc.date.none.fl_str_mv 2016-11
2016-11-01T00:00:00Z
2022-03-11T11:59:42Z
2022-01-28T17:54:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.3/6240
url http://hdl.handle.net/10400.3/6240
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Paiva, L., Lima, E., Baptista, J., & Neto, A.I.. (2016). Angiotensin I-converting enzyme (ACE) inhibitory activity of Fucus spiralis macroalgae and influence of the extracts storage temperature - A short report. “Journal of Pharmaceutical and Biomedical Analysis”, 131, 503–507. https://doi.org/10.1016/j.jpba.2016.08.029
0731-7085
cv-prod-2687102
10.1016/j.jpba.2016.08.029
1873-264X
27595387
000387628400062
dc.rights.driver.fl_str_mv metadata only access
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rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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