Drug Delivery from PCL/Chitosan Multilayer Coatings for Metallic Implants
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/143209 |
Resumo: | This work was partially funded by the FEDER funds through the COMPETE 2020 Program and National Funds through the FCT – Portuguese Foundation for Science and Technology under the projects UIDB/50025/2020-2023 (CENIMAT/I3N), and also partially supported by the project ERC-CoG-2014. The authors would like to thank the use of the traction machine at the Biomaterials Laboratory from the Soft and Bio-functional Materials Group (CENIMAT/I3N). |
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Drug Delivery from PCL/Chitosan Multilayer Coatings for Metallic ImplantsChemistry(all)Chemical Engineering(all)SDG 3 - Good Health and Well-beingThis work was partially funded by the FEDER funds through the COMPETE 2020 Program and National Funds through the FCT – Portuguese Foundation for Science and Technology under the projects UIDB/50025/2020-2023 (CENIMAT/I3N), and also partially supported by the project ERC-CoG-2014. The authors would like to thank the use of the traction machine at the Biomaterials Laboratory from the Soft and Bio-functional Materials Group (CENIMAT/I3N).Implant-related infections, mainly caused by Staphylococcus aureus, are a major health concern. Treatment is challenging due to multi-resistant strains and the ability of S. aureus to adhere and form biofilms on bone and implant surfaces. The present work involved the preparation and evaluation of a novel dual polymeric film coating on stainless steel. Chitosan and polycaprolactone (PCL) multilayers, loaded with poly(methyl methacrylate) (PMMA) microspheres encapsulating vancomycin or daptomycin, produced by the dip-coating technique, allowed local antibiotic-controlled delivery for the treatment of implant-related infections. Enhanced adhesion of the film to the metal substrate surface was achieved by mechanical abrasion of its surface. Studies have shown that for both drugs the release occurs by diffusion, but the release profile depends on the type of drug (daptomycin or vancomycin), the pH of the solution, and whether the drug is freestanding (directly incorporated into the films) or encapsulated in PMMA microspheres. Daptomycin freestanding films reached 90% release after 1 day at pH 7.4 and 4 days at pH 5.5. In comparison, films with daptomycin encapsulated microspheres reached 90% release after 2 h at pH 5.5 and 2 days at pH 7.4. Vancomycin encapsulated and freestanding films showed a similar behavior reaching 90% release after 20 h of release at pH 5.5 and 2 and 3 days, respectively, at pH 7.4. Furthermore, daptomycin-loaded films showed activity (assessed by agar diffusion assays) against sensitive (ATCC 25923) and clinically isolated (MRSA) S. aureus strains.DCM - Departamento de Ciência dos MateriaisCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)RUNSoares, I.Faria, Jaime Moreira MachadoMarques, A. C.Ribeiro, Isabel A. C.Baleizão, CarlosBettencourt, Ana F.Ferreira, IsabelBaptista, Ana Catarina2022-08-23T22:18:55Z2022-07-122022-07-12T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article11application/pdfhttp://hdl.handle.net/10362/143209eng2470-1343PURE: 45126245https://doi.org/10.1021/acsomega.2c00504info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:21:23Zoai:run.unl.pt:10362/143209Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:50:45.474505Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Drug Delivery from PCL/Chitosan Multilayer Coatings for Metallic Implants |
title |
Drug Delivery from PCL/Chitosan Multilayer Coatings for Metallic Implants |
spellingShingle |
Drug Delivery from PCL/Chitosan Multilayer Coatings for Metallic Implants Soares, I. Chemistry(all) Chemical Engineering(all) SDG 3 - Good Health and Well-being |
title_short |
Drug Delivery from PCL/Chitosan Multilayer Coatings for Metallic Implants |
title_full |
Drug Delivery from PCL/Chitosan Multilayer Coatings for Metallic Implants |
title_fullStr |
Drug Delivery from PCL/Chitosan Multilayer Coatings for Metallic Implants |
title_full_unstemmed |
Drug Delivery from PCL/Chitosan Multilayer Coatings for Metallic Implants |
title_sort |
Drug Delivery from PCL/Chitosan Multilayer Coatings for Metallic Implants |
author |
Soares, I. |
author_facet |
Soares, I. Faria, Jaime Moreira Machado Marques, A. C. Ribeiro, Isabel A. C. Baleizão, Carlos Bettencourt, Ana F. Ferreira, Isabel Baptista, Ana Catarina |
author_role |
author |
author2 |
Faria, Jaime Moreira Machado Marques, A. C. Ribeiro, Isabel A. C. Baleizão, Carlos Bettencourt, Ana F. Ferreira, Isabel Baptista, Ana Catarina |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
DCM - Departamento de Ciência dos Materiais CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N) RUN |
dc.contributor.author.fl_str_mv |
Soares, I. Faria, Jaime Moreira Machado Marques, A. C. Ribeiro, Isabel A. C. Baleizão, Carlos Bettencourt, Ana F. Ferreira, Isabel Baptista, Ana Catarina |
dc.subject.por.fl_str_mv |
Chemistry(all) Chemical Engineering(all) SDG 3 - Good Health and Well-being |
topic |
Chemistry(all) Chemical Engineering(all) SDG 3 - Good Health and Well-being |
description |
This work was partially funded by the FEDER funds through the COMPETE 2020 Program and National Funds through the FCT – Portuguese Foundation for Science and Technology under the projects UIDB/50025/2020-2023 (CENIMAT/I3N), and also partially supported by the project ERC-CoG-2014. The authors would like to thank the use of the traction machine at the Biomaterials Laboratory from the Soft and Bio-functional Materials Group (CENIMAT/I3N). |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-08-23T22:18:55Z 2022-07-12 2022-07-12T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/143209 |
url |
http://hdl.handle.net/10362/143209 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2470-1343 PURE: 45126245 https://doi.org/10.1021/acsomega.2c00504 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
11 application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799138103345020928 |