Environmental monitoring and biomarkers of exposure to styrene in chemical industry

Detalhes bibliográficos
Autor(a) principal: Fernandes, Daniela
Data de Publicação: 2017
Outros Autores: Meneses, Márcia, Albuquerque, Paula, Barros, Miguel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.21/8638
Resumo: ABSTRACT - Biomarkers of exposure to chemicals, such as styrene, allows to estimate the exposure to a particular compound by measuring the compound or it(s) metabolite(s) in body fluids. As an example, the determination of mandelic acid and phenylglyoxylic acid in urine. Indicators of genotoxicity are categorized as: (a) DNA and protein adducts; (b) DNA strand breaks. Styrene metabolism is initiated by Cytochrome P450 enzymes mediated by the oxidation of styrene to a reactive metabolite, the styrene-7,8-oxide. This study aims to review the environmental monitoring, complemented with biomarkers of exposure in order to understand its correlation and styrene genotoxicity. Systematic searches were performed to identify studies of occupational exposure to styrene and health effects in workers of chemical industries. To determine styrene air concentration, several studies used a personal air sampling method. A significant correlation has been found between styrene air concentration and mandelic and phenylglyoxylic acid concentration in urine. A significant relationship was found between individual levels of mandelic acid and phenylglyoxylic acid and styrene-7,8-oxide adducts to N-terminal valine in hemoglobin among exposed individuals. A strong correlation was also found between the frequency of DNA single-strand breaks, in mononuclear leukocytes, and styrene airborne level. The relationship between DNA damage, persistence and repair is complex, which complicates the relevance evaluation of potential genotoxic exposures difficult. There is conflicting evidence on the relationship between genotoxic response and exposure level. In future individual susceptibility studies, the individual genotypes associated with the metabolic route and DNA damage of styrene (metabolizing enzymes and DNA repair enzymes) should be analyzed. From the analysis of several studies it was found that indeed there is a strong correlation between the exposure levels and exposure biomarkers; however, no evidence was found regarding the styrene genotoxicity.
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spelling Environmental monitoring and biomarkers of exposure to styrene in chemical industryMonitorização ambiental e biomarcadores de exposição ao estireno na indústria químicaOccupational exposureStyreneChemical industryEnvironmental and biological monitoringExposure biomarkerExposição ocupacionalEstirenoIndústria químicaMonitorização ambiental e biológicaBiomarcadores de exposiçãoABSTRACT - Biomarkers of exposure to chemicals, such as styrene, allows to estimate the exposure to a particular compound by measuring the compound or it(s) metabolite(s) in body fluids. As an example, the determination of mandelic acid and phenylglyoxylic acid in urine. Indicators of genotoxicity are categorized as: (a) DNA and protein adducts; (b) DNA strand breaks. Styrene metabolism is initiated by Cytochrome P450 enzymes mediated by the oxidation of styrene to a reactive metabolite, the styrene-7,8-oxide. This study aims to review the environmental monitoring, complemented with biomarkers of exposure in order to understand its correlation and styrene genotoxicity. Systematic searches were performed to identify studies of occupational exposure to styrene and health effects in workers of chemical industries. To determine styrene air concentration, several studies used a personal air sampling method. A significant correlation has been found between styrene air concentration and mandelic and phenylglyoxylic acid concentration in urine. A significant relationship was found between individual levels of mandelic acid and phenylglyoxylic acid and styrene-7,8-oxide adducts to N-terminal valine in hemoglobin among exposed individuals. A strong correlation was also found between the frequency of DNA single-strand breaks, in mononuclear leukocytes, and styrene airborne level. The relationship between DNA damage, persistence and repair is complex, which complicates the relevance evaluation of potential genotoxic exposures difficult. There is conflicting evidence on the relationship between genotoxic response and exposure level. In future individual susceptibility studies, the individual genotypes associated with the metabolic route and DNA damage of styrene (metabolizing enzymes and DNA repair enzymes) should be analyzed. From the analysis of several studies it was found that indeed there is a strong correlation between the exposure levels and exposure biomarkers; however, no evidence was found regarding the styrene genotoxicity.RESUMO - Os biomarcadores de exposição a químicos, como o estireno, indicam que a exposição a um composto específico ocorre através da medição do composto inalterado ou do(s) seu(s) metabolito(s) nos fluídos corporais, como o ácido mandélico e o ácido fenilglioxílico presentes na urina. Os indicadores de genotoxicidade enquadram-se nas seguintes categorias: (a) adutos de proteínas e ADN; (b) quebras de ADN. O metabolismo do estireno é iniciado pelas enzimas do sistema citocromo P450, mediante a oxidação do estireno para um metabolito reativo, o 7,8-oxido de estireno. O presente estudo tem como objetivo a revisão de literatura relacionada com a monitorização ambiental do estireno e a existência de biomarcadores de exposição de forma a compreender a sua correlação com a genotoxicidade do estireno. Realizaram-se pesquisas sistemáticas para identificar estudos distintos de exposição ocupacional ao estireno e os seus efeitos na saúde de trabalhadores de indústrias químicas. Em resultado dessa pesquisa verificou-se que vários estudos referem a utilização de amostragem de ar pessoal para a determinação da concentração de estireno. Uma forte e significativa correlação foi encontrada entre a concentração de estireno no ar e a concentração de ácido mandélico e o fenilglioxílico na urina. Uma correlação significativa entre os níveis individuais de ácido mandélico e fenilglioxílico e a presença de adutos de 7,8-oxido de estireno no N-terminal da valina da hemoglobina foi igualmente encontrada nos indivíduos expostos a concentrações mais elevadas de estireno. Estes adutos de 7,8-oxido de estireno e hemoglobina persistem durante a vida útil dos eritrócitos. Estudos revelam também uma forte relação entre a frequência de quebras da cadeia simples do ADN nos leucócitos mononucleares e o nível de estireno presente no ar. A relação entre as lesões, a sua persistência e a reparação do ADN é complexa, o que dificulta a avaliação da relevância de potenciais exposições a substâncias genotóxicas. Existem evidências conflituantes da relação entre a resposta genotóxica e o nível de exposição. Como tal, os estudos sobre a suscetibilidade individual devem analisar e associar os genótipos individuais com a via metabólica do estireno e a lesão no ADN (metabolizando enzimas e enzimas de reparação do ADN). Concluiu-se que existe uma forte correlação entre os níveis de exposição e os biomarcadores de exposição. No entanto, não foram encontradas provas quanto à genotoxicidade do estireno.Instituto Politécnico de Lisboa, Escola Superior de Tecnologia da Saúde de LisboaRCIPLFernandes, DanielaMeneses, MárciaAlbuquerque, PaulaBarros, Miguel2018-06-25T18:40:16Z2017-112017-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/8638engFernandes D, Meneses M, Albuquerque P, Barros M. Environmental monitoring and biomarkers of exposure to styrene in chemical industry. Saúde & Tecnologia. 2017;(18):23-9.1646-9704info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T09:56:19Zoai:repositorio.ipl.pt:10400.21/8638Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:17:22.176553Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Environmental monitoring and biomarkers of exposure to styrene in chemical industry
Monitorização ambiental e biomarcadores de exposição ao estireno na indústria química
title Environmental monitoring and biomarkers of exposure to styrene in chemical industry
spellingShingle Environmental monitoring and biomarkers of exposure to styrene in chemical industry
Fernandes, Daniela
Occupational exposure
Styrene
Chemical industry
Environmental and biological monitoring
Exposure biomarker
Exposição ocupacional
Estireno
Indústria química
Monitorização ambiental e biológica
Biomarcadores de exposição
title_short Environmental monitoring and biomarkers of exposure to styrene in chemical industry
title_full Environmental monitoring and biomarkers of exposure to styrene in chemical industry
title_fullStr Environmental monitoring and biomarkers of exposure to styrene in chemical industry
title_full_unstemmed Environmental monitoring and biomarkers of exposure to styrene in chemical industry
title_sort Environmental monitoring and biomarkers of exposure to styrene in chemical industry
author Fernandes, Daniela
author_facet Fernandes, Daniela
Meneses, Márcia
Albuquerque, Paula
Barros, Miguel
author_role author
author2 Meneses, Márcia
Albuquerque, Paula
Barros, Miguel
author2_role author
author
author
dc.contributor.none.fl_str_mv RCIPL
dc.contributor.author.fl_str_mv Fernandes, Daniela
Meneses, Márcia
Albuquerque, Paula
Barros, Miguel
dc.subject.por.fl_str_mv Occupational exposure
Styrene
Chemical industry
Environmental and biological monitoring
Exposure biomarker
Exposição ocupacional
Estireno
Indústria química
Monitorização ambiental e biológica
Biomarcadores de exposição
topic Occupational exposure
Styrene
Chemical industry
Environmental and biological monitoring
Exposure biomarker
Exposição ocupacional
Estireno
Indústria química
Monitorização ambiental e biológica
Biomarcadores de exposição
description ABSTRACT - Biomarkers of exposure to chemicals, such as styrene, allows to estimate the exposure to a particular compound by measuring the compound or it(s) metabolite(s) in body fluids. As an example, the determination of mandelic acid and phenylglyoxylic acid in urine. Indicators of genotoxicity are categorized as: (a) DNA and protein adducts; (b) DNA strand breaks. Styrene metabolism is initiated by Cytochrome P450 enzymes mediated by the oxidation of styrene to a reactive metabolite, the styrene-7,8-oxide. This study aims to review the environmental monitoring, complemented with biomarkers of exposure in order to understand its correlation and styrene genotoxicity. Systematic searches were performed to identify studies of occupational exposure to styrene and health effects in workers of chemical industries. To determine styrene air concentration, several studies used a personal air sampling method. A significant correlation has been found between styrene air concentration and mandelic and phenylglyoxylic acid concentration in urine. A significant relationship was found between individual levels of mandelic acid and phenylglyoxylic acid and styrene-7,8-oxide adducts to N-terminal valine in hemoglobin among exposed individuals. A strong correlation was also found between the frequency of DNA single-strand breaks, in mononuclear leukocytes, and styrene airborne level. The relationship between DNA damage, persistence and repair is complex, which complicates the relevance evaluation of potential genotoxic exposures difficult. There is conflicting evidence on the relationship between genotoxic response and exposure level. In future individual susceptibility studies, the individual genotypes associated with the metabolic route and DNA damage of styrene (metabolizing enzymes and DNA repair enzymes) should be analyzed. From the analysis of several studies it was found that indeed there is a strong correlation between the exposure levels and exposure biomarkers; however, no evidence was found regarding the styrene genotoxicity.
publishDate 2017
dc.date.none.fl_str_mv 2017-11
2017-11-01T00:00:00Z
2018-06-25T18:40:16Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.21/8638
url http://hdl.handle.net/10400.21/8638
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Fernandes D, Meneses M, Albuquerque P, Barros M. Environmental monitoring and biomarkers of exposure to styrene in chemical industry. Saúde & Tecnologia. 2017;(18):23-9.
1646-9704
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Instituto Politécnico de Lisboa, Escola Superior de Tecnologia da Saúde de Lisboa
publisher.none.fl_str_mv Instituto Politécnico de Lisboa, Escola Superior de Tecnologia da Saúde de Lisboa
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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