Multidisciplinary utilization of dimethyl sulfoxide : pharmacological, cellular, and molecular aspects

Detalhes bibliográficos
Autor(a) principal: Santos, Nuno C.
Data de Publicação: 2003
Outros Autores: Figueira-Coelho, J., Martins-Silva, João, Saldanha, Carlota
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/17632
Resumo: © 2003 Elsevier Science Inc. All rights reserved.
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spelling Multidisciplinary utilization of dimethyl sulfoxide : pharmacological, cellular, and molecular aspectsDimethyl sulfoxideAmyloidosisInflammationCell cycleCell differentiationCryopreservation© 2003 Elsevier Science Inc. All rights reserved.DMSO is an amphipathic molecule with a highly polar domain and two apolar methyl groups, making it soluble in both aqueous and organic media. It is one of the most common solvents for the in vivo administration of several water-insoluble substances. Despite being frequently used as a solvent in biological studies and as a vehicle for drug therapy, the side-effects of DMSO (undesirable for these purposes) are apparent from its utilization in the laboratory (both in vivo and in vitro) and in clinical settings. DMSO is a hydrogen-bound disrupter, cell-differentiating agent, hydroxyl radical scavenger, intercellular electrical uncoupler, intracellular low-density lipoproteinderived cholesterol mobilizing agent, cryoprotectant, solubilizing agent used in sample preparation for electron microscopy, antidote to the extravasation of vesicant anticancer agents, and topical analgesic. Additionally, it is used in the treatment of brain edema, amyloidosis, interstitial cystitis, and schizophrenia. Several systemic side-effects from the use of DMSO have been reported, namely nausea, vomiting, diarrhea, hemolysis, rashes, renal failure, hypertension, bradycardia, heart block, pulmonary edema, cardiac arrest, and bronchospasm. Looking at the multitude of effects of DMSO brought to light by these studies, it is easily understood how many researchers working with DMSO (or studying one of its specific effects) might not be fully aware of the experiences of other groups who are working with it but in a different context.This work was partially supported by the Fundação para a Ciência e Tecnologia (FCT) and by the Calouste Gulbenkian Foundation (Portugal).ElsevierRepositório da Universidade de LisboaSantos, Nuno C.Figueira-Coelho, J.Martins-Silva, JoãoSaldanha, Carlota2015-03-05T15:41:17Z20032003-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/17632engBiochemical Pharmacology 65 (2003) 1035–10410006-2952http://dx.doi.org/10.1016/S0006-2952(03)00002-9metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:03:22Zoai:repositorio.ul.pt:10451/17632Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:37:27.282416Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Multidisciplinary utilization of dimethyl sulfoxide : pharmacological, cellular, and molecular aspects
title Multidisciplinary utilization of dimethyl sulfoxide : pharmacological, cellular, and molecular aspects
spellingShingle Multidisciplinary utilization of dimethyl sulfoxide : pharmacological, cellular, and molecular aspects
Santos, Nuno C.
Dimethyl sulfoxide
Amyloidosis
Inflammation
Cell cycle
Cell differentiation
Cryopreservation
title_short Multidisciplinary utilization of dimethyl sulfoxide : pharmacological, cellular, and molecular aspects
title_full Multidisciplinary utilization of dimethyl sulfoxide : pharmacological, cellular, and molecular aspects
title_fullStr Multidisciplinary utilization of dimethyl sulfoxide : pharmacological, cellular, and molecular aspects
title_full_unstemmed Multidisciplinary utilization of dimethyl sulfoxide : pharmacological, cellular, and molecular aspects
title_sort Multidisciplinary utilization of dimethyl sulfoxide : pharmacological, cellular, and molecular aspects
author Santos, Nuno C.
author_facet Santos, Nuno C.
Figueira-Coelho, J.
Martins-Silva, João
Saldanha, Carlota
author_role author
author2 Figueira-Coelho, J.
Martins-Silva, João
Saldanha, Carlota
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Santos, Nuno C.
Figueira-Coelho, J.
Martins-Silva, João
Saldanha, Carlota
dc.subject.por.fl_str_mv Dimethyl sulfoxide
Amyloidosis
Inflammation
Cell cycle
Cell differentiation
Cryopreservation
topic Dimethyl sulfoxide
Amyloidosis
Inflammation
Cell cycle
Cell differentiation
Cryopreservation
description © 2003 Elsevier Science Inc. All rights reserved.
publishDate 2003
dc.date.none.fl_str_mv 2003
2003-01-01T00:00:00Z
2015-03-05T15:41:17Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/17632
url http://hdl.handle.net/10451/17632
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Biochemical Pharmacology 65 (2003) 1035–1041
0006-2952
http://dx.doi.org/10.1016/S0006-2952(03)00002-9
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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