From the periphery to the brain: Lipocalin-2, a friend or foe?
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/40045 |
Resumo: | Lipocalin-2 (LCN2) is an acute-phase protein that, by binding to iron-loaded siderophores, acts as a potent bacteriostatic agent in the iron-depletion strategy of the immune system to control pathogens. The recent identification of a mammalian siderophore also suggests a physiological role for LCN2 in iron homeostasis, specifically in iron delivery to cells via a transferrin-independent mechanism. LCN2 participates, as well, in a variety of cellular processes, including cell proliferation, cell differentiation and apoptosis, and has been mostly found up-regulated in various tissues and under inflammatory states, being its expression regulated by several inducers. In the central nervous system less is known about the processes involving LCN2, namely by which cells it is produced/secreted, and its impact on cell proliferation and death, or in neuronal plasticity and behaviour. Importantly, LCN2 recently emerged as a potential clinical biomarker in multiple sclerosis and in ageing-related cognitive decline. Still, there are conflicting views on the role of LCN2 in pathophysiological processes, with some studies pointing to its neurodeleterious effects, while others indicate neuroprotection. Herein, these various perspectives are reviewed and a comprehensive and cohesive view of the general function of LCN2, particularly in the brain, is provided. |
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From the periphery to the brain: Lipocalin-2, a friend or foe?Lipocalin-2AstrocytesCentral nervous systemMultiple sclerosisAlzheimer’s diseaseIronScience & TechnologyLipocalin-2 (LCN2) is an acute-phase protein that, by binding to iron-loaded siderophores, acts as a potent bacteriostatic agent in the iron-depletion strategy of the immune system to control pathogens. The recent identification of a mammalian siderophore also suggests a physiological role for LCN2 in iron homeostasis, specifically in iron delivery to cells via a transferrin-independent mechanism. LCN2 participates, as well, in a variety of cellular processes, including cell proliferation, cell differentiation and apoptosis, and has been mostly found up-regulated in various tissues and under inflammatory states, being its expression regulated by several inducers. In the central nervous system less is known about the processes involving LCN2, namely by which cells it is produced/secreted, and its impact on cell proliferation and death, or in neuronal plasticity and behaviour. Importantly, LCN2 recently emerged as a potential clinical biomarker in multiple sclerosis and in ageing-related cognitive decline. Still, there are conflicting views on the role of LCN2 in pathophysiological processes, with some studies pointing to its neurodeleterious effects, while others indicate neuroprotection. Herein, these various perspectives are reviewed and a comprehensive and cohesive view of the general function of LCN2, particularly in the brain, is provided.Ana Catarina Ferreira and Sandro Da Mesquita are recipients of PhD fellowships by the Fundação para a Ciência e Tecnologia (FCT, Portugal)/FEDER. Fernanda Marques is an assistant researcher IF/ 00231/2013 of the Fundação para a Ciência e Tecnologia (FCT, Portugal). This work was supported by Fundação para a Ciência e Tecnologia (FCT) and COMPETE through the project: EXPL/NEUOSD/2196/2013 (to Marques F). The authors thank Nadine Santos for the helpful comments on the manuscript.ElsevierUniversidade do MinhoFerreira, Ana CatarinaMesquita, Sandro Gabriel Ferreira DáSousa, João CarlosNeves, Margarida CorreiaSousa, NunoPalha, Joana AlmeidaMarques, Fernanda20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/40045engFerreira, A. C., Da Mesquita, S., Sousa, J. C., Correia-Neves, M., Sousa, N., Palha, J. A., & Marques, F. (2015). From the periphery to the brain: Lipocalin-2, a friend or foe? Progress in Neurobiology, 131, 120-136. doi: 10.1016/j.pneurobio.2015.06.0050301-008210.1016/j.pneurobio.2015.06.00526159707http://www.sciencedirect.com/science/journal/03010082info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:18:49Zoai:repositorium.sdum.uminho.pt:1822/40045Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:11:39.491147Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
From the periphery to the brain: Lipocalin-2, a friend or foe? |
title |
From the periphery to the brain: Lipocalin-2, a friend or foe? |
spellingShingle |
From the periphery to the brain: Lipocalin-2, a friend or foe? Ferreira, Ana Catarina Lipocalin-2 Astrocytes Central nervous system Multiple sclerosis Alzheimer’s disease Iron Science & Technology |
title_short |
From the periphery to the brain: Lipocalin-2, a friend or foe? |
title_full |
From the periphery to the brain: Lipocalin-2, a friend or foe? |
title_fullStr |
From the periphery to the brain: Lipocalin-2, a friend or foe? |
title_full_unstemmed |
From the periphery to the brain: Lipocalin-2, a friend or foe? |
title_sort |
From the periphery to the brain: Lipocalin-2, a friend or foe? |
author |
Ferreira, Ana Catarina |
author_facet |
Ferreira, Ana Catarina Mesquita, Sandro Gabriel Ferreira Dá Sousa, João Carlos Neves, Margarida Correia Sousa, Nuno Palha, Joana Almeida Marques, Fernanda |
author_role |
author |
author2 |
Mesquita, Sandro Gabriel Ferreira Dá Sousa, João Carlos Neves, Margarida Correia Sousa, Nuno Palha, Joana Almeida Marques, Fernanda |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Ferreira, Ana Catarina Mesquita, Sandro Gabriel Ferreira Dá Sousa, João Carlos Neves, Margarida Correia Sousa, Nuno Palha, Joana Almeida Marques, Fernanda |
dc.subject.por.fl_str_mv |
Lipocalin-2 Astrocytes Central nervous system Multiple sclerosis Alzheimer’s disease Iron Science & Technology |
topic |
Lipocalin-2 Astrocytes Central nervous system Multiple sclerosis Alzheimer’s disease Iron Science & Technology |
description |
Lipocalin-2 (LCN2) is an acute-phase protein that, by binding to iron-loaded siderophores, acts as a potent bacteriostatic agent in the iron-depletion strategy of the immune system to control pathogens. The recent identification of a mammalian siderophore also suggests a physiological role for LCN2 in iron homeostasis, specifically in iron delivery to cells via a transferrin-independent mechanism. LCN2 participates, as well, in a variety of cellular processes, including cell proliferation, cell differentiation and apoptosis, and has been mostly found up-regulated in various tissues and under inflammatory states, being its expression regulated by several inducers. In the central nervous system less is known about the processes involving LCN2, namely by which cells it is produced/secreted, and its impact on cell proliferation and death, or in neuronal plasticity and behaviour. Importantly, LCN2 recently emerged as a potential clinical biomarker in multiple sclerosis and in ageing-related cognitive decline. Still, there are conflicting views on the role of LCN2 in pathophysiological processes, with some studies pointing to its neurodeleterious effects, while others indicate neuroprotection. Herein, these various perspectives are reviewed and a comprehensive and cohesive view of the general function of LCN2, particularly in the brain, is provided. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015 2015-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/40045 |
url |
http://hdl.handle.net/1822/40045 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Ferreira, A. C., Da Mesquita, S., Sousa, J. C., Correia-Neves, M., Sousa, N., Palha, J. A., & Marques, F. (2015). From the periphery to the brain: Lipocalin-2, a friend or foe? Progress in Neurobiology, 131, 120-136. doi: 10.1016/j.pneurobio.2015.06.005 0301-0082 10.1016/j.pneurobio.2015.06.005 26159707 http://www.sciencedirect.com/science/journal/03010082 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132549516099584 |