Identification of hereditary cancer in the general population: development and validation of a screening questionnaire for obtaining the family history of cancer
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/48437 |
Resumo: | One of the challenges for Latin American countries is to include in their healthcare systems technologies that can be applied to hereditary cancer detection and management. The aim of the study is to create and validate a questionnaire to identify individuals with possible risk for hereditary cancer predisposition syndromes (HCPS), using different strategies in a Cancer Prevention Service in Brazil. The primary screening questionnaire (PSQ) was developed to identify families at-risk for HCPS. The PSQ was validated using discrimination measures, and the reproducibility was estimated through kappa coefficient. Patients with at least one affirmative answer had the pedigree drawn using three alternative interview approaches: in-person, by telephone, or letter. Validation of these approaches was done. Kappa and intraclass correlation coefficients were used to analyze data’s reproducibility considering the presence of clinical criteria for HCPS. The PSQ was applied to a convenience sample of 20,000 women of which 3121 (15.6%) answered at least one affirmative question and 1938 had their pedigrees drawn. The PSQ showed sensitivity and specificity scores of 94.4% and 75%, respectively, and a kappa of 0.64. The strategies for pedigree drawing had reproducibility coefficients of 0.976 and 0.850 for the telephone and letter approaches, respectively. Pedigree analysis allowed us to identify 465 individuals (24.0%) fulfilling at least one clinical criterion for HCPS. The PSQ fulfills its function, allowing the identification of HCPS at-risk families. The use of alternative screening methods may reduce the number of excluded at-risk individuals/families who live in locations where oncogenetic services are not established. |
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Identification of hereditary cancer in the general population: development and validation of a screening questionnaire for obtaining the family history of cancerHereditary cancerHereditary cancer in low-income countriesHereditary cancer screening strategiesOncogeneticPedigree drawing strategiesScience & TechnologyOne of the challenges for Latin American countries is to include in their healthcare systems technologies that can be applied to hereditary cancer detection and management. The aim of the study is to create and validate a questionnaire to identify individuals with possible risk for hereditary cancer predisposition syndromes (HCPS), using different strategies in a Cancer Prevention Service in Brazil. The primary screening questionnaire (PSQ) was developed to identify families at-risk for HCPS. The PSQ was validated using discrimination measures, and the reproducibility was estimated through kappa coefficient. Patients with at least one affirmative answer had the pedigree drawn using three alternative interview approaches: in-person, by telephone, or letter. Validation of these approaches was done. Kappa and intraclass correlation coefficients were used to analyze data’s reproducibility considering the presence of clinical criteria for HCPS. The PSQ was applied to a convenience sample of 20,000 women of which 3121 (15.6%) answered at least one affirmative question and 1938 had their pedigrees drawn. The PSQ showed sensitivity and specificity scores of 94.4% and 75%, respectively, and a kappa of 0.64. The strategies for pedigree drawing had reproducibility coefficients of 0.976 and 0.850 for the telephone and letter approaches, respectively. Pedigree analysis allowed us to identify 465 individuals (24.0%) fulfilling at least one clinical criterion for HCPS. The PSQ fulfills its function, allowing the identification of HCPS at-risk families. The use of alternative screening methods may reduce the number of excluded at-risk individuals/families who live in locations where oncogenetic services are not established.Research supported by Barretos Cancer Hospital. EIP has a grant from FAPESP (FAPESP, SP, Brazil, #2013/24633-2). N Campacci is supported by a PhD fellowship from FAPESP (FAPESP, SP, Brazil, #2015/02444-9).info:eu-repo/semantics/publishedVersionJohn Wiley and SonsUniversidade do MinhoCampacci, NatáliaLima, Juliana O. deCarvalho, André LopesMichelli, Rodrigo A. D.Haikel Junior, Raphael L.Mauad, EdmundoViana, DaniloMelendez, Matias EliseoVazquez, Fabiana de LimaZanardo, CleytonReis, R. M.Rossi, Benedito M.Palmero, Edenir I.2017-082017-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/48437engCancer Medicine 2017; 6(12):3014–30242045-763410.1002/cam4.121029055968http://onlinelibrary.wiley.com/doi/10.1002/cam4.1210/abstractinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:40:50Zoai:repositorium.sdum.uminho.pt:1822/48437Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:37:41.895680Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Identification of hereditary cancer in the general population: development and validation of a screening questionnaire for obtaining the family history of cancer |
title |
Identification of hereditary cancer in the general population: development and validation of a screening questionnaire for obtaining the family history of cancer |
spellingShingle |
Identification of hereditary cancer in the general population: development and validation of a screening questionnaire for obtaining the family history of cancer Campacci, Natália Hereditary cancer Hereditary cancer in low-income countries Hereditary cancer screening strategies Oncogenetic Pedigree drawing strategies Science & Technology |
title_short |
Identification of hereditary cancer in the general population: development and validation of a screening questionnaire for obtaining the family history of cancer |
title_full |
Identification of hereditary cancer in the general population: development and validation of a screening questionnaire for obtaining the family history of cancer |
title_fullStr |
Identification of hereditary cancer in the general population: development and validation of a screening questionnaire for obtaining the family history of cancer |
title_full_unstemmed |
Identification of hereditary cancer in the general population: development and validation of a screening questionnaire for obtaining the family history of cancer |
title_sort |
Identification of hereditary cancer in the general population: development and validation of a screening questionnaire for obtaining the family history of cancer |
author |
Campacci, Natália |
author_facet |
Campacci, Natália Lima, Juliana O. de Carvalho, André Lopes Michelli, Rodrigo A. D. Haikel Junior, Raphael L. Mauad, Edmundo Viana, Danilo Melendez, Matias Eliseo Vazquez, Fabiana de Lima Zanardo, Cleyton Reis, R. M. Rossi, Benedito M. Palmero, Edenir I. |
author_role |
author |
author2 |
Lima, Juliana O. de Carvalho, André Lopes Michelli, Rodrigo A. D. Haikel Junior, Raphael L. Mauad, Edmundo Viana, Danilo Melendez, Matias Eliseo Vazquez, Fabiana de Lima Zanardo, Cleyton Reis, R. M. Rossi, Benedito M. Palmero, Edenir I. |
author2_role |
author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Campacci, Natália Lima, Juliana O. de Carvalho, André Lopes Michelli, Rodrigo A. D. Haikel Junior, Raphael L. Mauad, Edmundo Viana, Danilo Melendez, Matias Eliseo Vazquez, Fabiana de Lima Zanardo, Cleyton Reis, R. M. Rossi, Benedito M. Palmero, Edenir I. |
dc.subject.por.fl_str_mv |
Hereditary cancer Hereditary cancer in low-income countries Hereditary cancer screening strategies Oncogenetic Pedigree drawing strategies Science & Technology |
topic |
Hereditary cancer Hereditary cancer in low-income countries Hereditary cancer screening strategies Oncogenetic Pedigree drawing strategies Science & Technology |
description |
One of the challenges for Latin American countries is to include in their healthcare systems technologies that can be applied to hereditary cancer detection and management. The aim of the study is to create and validate a questionnaire to identify individuals with possible risk for hereditary cancer predisposition syndromes (HCPS), using different strategies in a Cancer Prevention Service in Brazil. The primary screening questionnaire (PSQ) was developed to identify families at-risk for HCPS. The PSQ was validated using discrimination measures, and the reproducibility was estimated through kappa coefficient. Patients with at least one affirmative answer had the pedigree drawn using three alternative interview approaches: in-person, by telephone, or letter. Validation of these approaches was done. Kappa and intraclass correlation coefficients were used to analyze data’s reproducibility considering the presence of clinical criteria for HCPS. The PSQ was applied to a convenience sample of 20,000 women of which 3121 (15.6%) answered at least one affirmative question and 1938 had their pedigrees drawn. The PSQ showed sensitivity and specificity scores of 94.4% and 75%, respectively, and a kappa of 0.64. The strategies for pedigree drawing had reproducibility coefficients of 0.976 and 0.850 for the telephone and letter approaches, respectively. Pedigree analysis allowed us to identify 465 individuals (24.0%) fulfilling at least one clinical criterion for HCPS. The PSQ fulfills its function, allowing the identification of HCPS at-risk families. The use of alternative screening methods may reduce the number of excluded at-risk individuals/families who live in locations where oncogenetic services are not established. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-08 2017-08-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/48437 |
url |
http://hdl.handle.net/1822/48437 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Cancer Medicine 2017; 6(12):3014–3024 2045-7634 10.1002/cam4.1210 29055968 http://onlinelibrary.wiley.com/doi/10.1002/cam4.1210/abstract |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
John Wiley and Sons |
publisher.none.fl_str_mv |
John Wiley and Sons |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132911660695552 |