Anal Cancer in HIV Patients - Experience at Hospital de Curry Cabral

Detalhes bibliográficos
Autor(a) principal: Póvoas, Dina
Data de Publicação: 2016
Outros Autores: Fernandes, Cândida, Macia, Vasco, Flor de Lima, Bárbara, Rodrigues, Ana, Maltez, Fernando, Cardoso, Jorge
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.29021/spdv.74.2.555
Resumo: Introduction: Men who have sex with men, particularly those infected by human immunodeficiency virus (HIV), have an increased risk of anal cancer. Unlike most opportunistic or AIDS-defining events, data have been contradictory regarding impact of antiretroviral therapy, viral suppression and immunologic reconstitution on HPV infection prevention and related cancers. Vaccination against human papillomavirus (HPV) is presently recommended in all HIV-infected patients, whereas there is still an on-going debate about the need for anal cancer screening programmes.Material and methods: The authors performed a retrospective study of anal cancer cases diagnosed between 2000-2015 in HIV patients on follow up at the Infectious Diseases Unit at Hospital de Curry Cabral, in Lisbon. We present the clinical and epidemiological characteristics of anal cancer cases throughout a fifteen-year period.Results: Anal cancer was diagnosed in ten patients, most of them MSM, HIV-infected for an average time of 15.1 years, with an average TCD4+ cell count of de 441 cells/uL. Anal cancer diagnosis was more frequently performed at stage III and treatment most frequently involved surgery, occasionally with radiotherapy. Four patients died.Conclusion: There is a need for consensual anal cancer screening programs, along with a need to reinforce HPV vaccination in men, particularly men who have sex with men, regardless of HIV infection.
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spelling Anal Cancer in HIV Patients - Experience at Hospital de Curry CabralCancro Anal em Doentes com Infecção por VIH - Experiência do Hospital de Curry CabralAnus NeoplasmsHIV InfectionsHomosexualityMalePapillomavirus InfectionsHomossexualidade MasculinaInfecções por VIHInfecções por PapilomavirusNeoplasias do ÂnusIntroduction: Men who have sex with men, particularly those infected by human immunodeficiency virus (HIV), have an increased risk of anal cancer. Unlike most opportunistic or AIDS-defining events, data have been contradictory regarding impact of antiretroviral therapy, viral suppression and immunologic reconstitution on HPV infection prevention and related cancers. Vaccination against human papillomavirus (HPV) is presently recommended in all HIV-infected patients, whereas there is still an on-going debate about the need for anal cancer screening programmes.Material and methods: The authors performed a retrospective study of anal cancer cases diagnosed between 2000-2015 in HIV patients on follow up at the Infectious Diseases Unit at Hospital de Curry Cabral, in Lisbon. We present the clinical and epidemiological characteristics of anal cancer cases throughout a fifteen-year period.Results: Anal cancer was diagnosed in ten patients, most of them MSM, HIV-infected for an average time of 15.1 years, with an average TCD4+ cell count of de 441 cells/uL. Anal cancer diagnosis was more frequently performed at stage III and treatment most frequently involved surgery, occasionally with radiotherapy. Four patients died.Conclusion: There is a need for consensual anal cancer screening programs, along with a need to reinforce HPV vaccination in men, particularly men who have sex with men, regardless of HIV infection.Introdução: Os homens que têm sexo com homens, particularmente os infectados pelo vírus da imunodeficiência humana (VIH) têm risco aumentado de cancro anal. Ao contrário da maior parte das doenças oportunistas e/ou definidoras de SIDA, os dados são contraditórios no que diz respeito ao efeito da terapêutica antirretrovírica, não sendo claro o impacto da supressão virológica e reconstituição imunitária na evolução da infecção por vírus do papiloma humano (HPV) e prevenção das neoplasias associadas. Actualmente é já recomendada a vacinação de doentes com infecção por VIH contra o HPV; os programas de rastreio do cancro anal, recomendados por algumas organizações, carecem ainda de validação definitiva da sua eficácia.Material e Métodos: Os autores fizeram um estudo retrospectivo dos casos de cancro anal diagnosticados entre 2000-2015 em doentes com infecção por VIH em seguimento no serviço de Infecciologia do Hospital de Curry Cabral, em Lisboa. São avaliadas as características clínicas e epidemiológicas dos doentes com cancro do canal anal ao longo de um período de quinze anos.Resultados: O cancro anal foi diagnosticado em dez doentes, maioritariamente homens HSH, com infecção por VIH com uma duração média de 15,1 anos, com contagem média de linfócitos TCD4+ de 441 células/uL. O diagnóstico foi mais frequentemente realizado no estádio III e o tratamento mais frequente foi cirúrgico, ocasionalmente conjugado com radioterapia. Faleceram 4 doentes.Conclusões: São necessários programas de rastreio consensuais do cancro anal, a par da necessidade de reforço da vacinação contra o HPV nos homens, nomeadamente nos homens que têm sexo com homens, com ou sem infecção por VIH.Sociedade Portuguesa de Dermatologia e Venereologia2016-08-03T00:00:00Zjournal articleinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.29021/spdv.74.2.555oai:ojs.revista.spdv.com.pt:article/555Journal of the Portuguese Society of Dermatology and Venereology; Vol 74 No 2 (2016): Abril / Junho; 179-184Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 74 n. 2 (2016): Abril / Junho; 179-1842182-24092182-2395reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://revista.spdv.com.pt/index.php/spdv/article/view/555https://doi.org/10.29021/spdv.74.2.555https://revista.spdv.com.pt/index.php/spdv/article/view/555/407Póvoas, DinaFernandes, CândidaMacia, VascoFlor de Lima, BárbaraRodrigues, AnaMaltez, FernandoCardoso, Jorgeinfo:eu-repo/semantics/openAccess2022-10-06T12:34:57Zoai:ojs.revista.spdv.com.pt:article/555Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:10:56.863878Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Anal Cancer in HIV Patients - Experience at Hospital de Curry Cabral
Cancro Anal em Doentes com Infecção por VIH - Experiência do Hospital de Curry Cabral
title Anal Cancer in HIV Patients - Experience at Hospital de Curry Cabral
spellingShingle Anal Cancer in HIV Patients - Experience at Hospital de Curry Cabral
Póvoas, Dina
Anus Neoplasms
HIV Infections
Homosexuality
Male
Papillomavirus Infections
Homossexualidade Masculina
Infecções por VIH
Infecções por Papilomavirus
Neoplasias do Ânus
title_short Anal Cancer in HIV Patients - Experience at Hospital de Curry Cabral
title_full Anal Cancer in HIV Patients - Experience at Hospital de Curry Cabral
title_fullStr Anal Cancer in HIV Patients - Experience at Hospital de Curry Cabral
title_full_unstemmed Anal Cancer in HIV Patients - Experience at Hospital de Curry Cabral
title_sort Anal Cancer in HIV Patients - Experience at Hospital de Curry Cabral
author Póvoas, Dina
author_facet Póvoas, Dina
Fernandes, Cândida
Macia, Vasco
Flor de Lima, Bárbara
Rodrigues, Ana
Maltez, Fernando
Cardoso, Jorge
author_role author
author2 Fernandes, Cândida
Macia, Vasco
Flor de Lima, Bárbara
Rodrigues, Ana
Maltez, Fernando
Cardoso, Jorge
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Póvoas, Dina
Fernandes, Cândida
Macia, Vasco
Flor de Lima, Bárbara
Rodrigues, Ana
Maltez, Fernando
Cardoso, Jorge
dc.subject.por.fl_str_mv Anus Neoplasms
HIV Infections
Homosexuality
Male
Papillomavirus Infections
Homossexualidade Masculina
Infecções por VIH
Infecções por Papilomavirus
Neoplasias do Ânus
topic Anus Neoplasms
HIV Infections
Homosexuality
Male
Papillomavirus Infections
Homossexualidade Masculina
Infecções por VIH
Infecções por Papilomavirus
Neoplasias do Ânus
description Introduction: Men who have sex with men, particularly those infected by human immunodeficiency virus (HIV), have an increased risk of anal cancer. Unlike most opportunistic or AIDS-defining events, data have been contradictory regarding impact of antiretroviral therapy, viral suppression and immunologic reconstitution on HPV infection prevention and related cancers. Vaccination against human papillomavirus (HPV) is presently recommended in all HIV-infected patients, whereas there is still an on-going debate about the need for anal cancer screening programmes.Material and methods: The authors performed a retrospective study of anal cancer cases diagnosed between 2000-2015 in HIV patients on follow up at the Infectious Diseases Unit at Hospital de Curry Cabral, in Lisbon. We present the clinical and epidemiological characteristics of anal cancer cases throughout a fifteen-year period.Results: Anal cancer was diagnosed in ten patients, most of them MSM, HIV-infected for an average time of 15.1 years, with an average TCD4+ cell count of de 441 cells/uL. Anal cancer diagnosis was more frequently performed at stage III and treatment most frequently involved surgery, occasionally with radiotherapy. Four patients died.Conclusion: There is a need for consensual anal cancer screening programs, along with a need to reinforce HPV vaccination in men, particularly men who have sex with men, regardless of HIV infection.
publishDate 2016
dc.date.none.fl_str_mv 2016-08-03T00:00:00Z
dc.type.driver.fl_str_mv journal article
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dc.identifier.uri.fl_str_mv https://doi.org/10.29021/spdv.74.2.555
oai:ojs.revista.spdv.com.pt:article/555
url https://doi.org/10.29021/spdv.74.2.555
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dc.relation.none.fl_str_mv https://revista.spdv.com.pt/index.php/spdv/article/view/555
https://doi.org/10.29021/spdv.74.2.555
https://revista.spdv.com.pt/index.php/spdv/article/view/555/407
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Sociedade Portuguesa de Dermatologia e Venereologia
publisher.none.fl_str_mv Sociedade Portuguesa de Dermatologia e Venereologia
dc.source.none.fl_str_mv Journal of the Portuguese Society of Dermatology and Venereology; Vol 74 No 2 (2016): Abril / Junho; 179-184
Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 74 n. 2 (2016): Abril / Junho; 179-184
2182-2409
2182-2395
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