Solid lipid nanoparticles vs. nanostructured lipid carriers: a comparative review

Detalhes bibliográficos
Autor(a) principal: Viegas, Cláudia
Data de Publicação: 2023
Outros Autores: Patrício, Ana B., Prata, João M., Nadhman, Akhtar, Chintamaneni, Pavan Kumar, Fonte, Pedro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.1/19772
Resumo: Solid–lipid nanoparticles and nanostructured lipid carriers are delivery systems for the delivery of drugs and other bioactives used in diagnosis, therapy, and treatment procedures. These nanocarriers may enhance the solubility and permeability of drugs, increase their bioavailability, and extend the residence time in the body, combining low toxicity with a targeted delivery. Nanostructured lipid carriers are the second generation of lipid nanoparticles differing from solid lipid nanoparticles in their composition matrix. The use of a liquid lipid together with a solid lipid in nanostructured lipid carrier allows it to load a higher amount of drug, enhance drug release properties, and increase its stability. Therefore, a direct comparison between solid lipid nanoparticles and nanostructured lipid carriers is needed. This review aims to describe solid lipid nanoparticles and nanostructured lipid carriers as drug delivery systems, comparing both, while systematically elucidating their production methodologies, physicochemical characterization, and in vitro and in vivo performance. In addition, the toxicity concerns of these systems are focused on.
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spelling Solid lipid nanoparticles vs. nanostructured lipid carriers: a comparative reviewSolid–lipid nanoparticles and nanostructured lipid carriers are delivery systems for the delivery of drugs and other bioactives used in diagnosis, therapy, and treatment procedures. These nanocarriers may enhance the solubility and permeability of drugs, increase their bioavailability, and extend the residence time in the body, combining low toxicity with a targeted delivery. Nanostructured lipid carriers are the second generation of lipid nanoparticles differing from solid lipid nanoparticles in their composition matrix. The use of a liquid lipid together with a solid lipid in nanostructured lipid carrier allows it to load a higher amount of drug, enhance drug release properties, and increase its stability. Therefore, a direct comparison between solid lipid nanoparticles and nanostructured lipid carriers is needed. This review aims to describe solid lipid nanoparticles and nanostructured lipid carriers as drug delivery systems, comparing both, while systematically elucidating their production methodologies, physicochemical characterization, and in vitro and in vivo performance. In addition, the toxicity concerns of these systems are focused on.MDPISapientiaViegas, CláudiaPatrício, Ana B.Prata, João M.Nadhman, AkhtarChintamaneni, Pavan KumarFonte, Pedro2023-06-28T09:35:02Z2023-05-252023-06-27T13:21:49Z2023-05-25T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/19772engPharmaceutics 15 (6): 1593 (2023)doi: 10.3390/pharmaceutics1506159310.3390/pharmaceutics15061593info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-24T02:00:39Zoai:sapientia.ualg.pt:10400.1/19772Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:09:19.786699Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Solid lipid nanoparticles vs. nanostructured lipid carriers: a comparative review
title Solid lipid nanoparticles vs. nanostructured lipid carriers: a comparative review
spellingShingle Solid lipid nanoparticles vs. nanostructured lipid carriers: a comparative review
Viegas, Cláudia
title_short Solid lipid nanoparticles vs. nanostructured lipid carriers: a comparative review
title_full Solid lipid nanoparticles vs. nanostructured lipid carriers: a comparative review
title_fullStr Solid lipid nanoparticles vs. nanostructured lipid carriers: a comparative review
title_full_unstemmed Solid lipid nanoparticles vs. nanostructured lipid carriers: a comparative review
title_sort Solid lipid nanoparticles vs. nanostructured lipid carriers: a comparative review
author Viegas, Cláudia
author_facet Viegas, Cláudia
Patrício, Ana B.
Prata, João M.
Nadhman, Akhtar
Chintamaneni, Pavan Kumar
Fonte, Pedro
author_role author
author2 Patrício, Ana B.
Prata, João M.
Nadhman, Akhtar
Chintamaneni, Pavan Kumar
Fonte, Pedro
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Sapientia
dc.contributor.author.fl_str_mv Viegas, Cláudia
Patrício, Ana B.
Prata, João M.
Nadhman, Akhtar
Chintamaneni, Pavan Kumar
Fonte, Pedro
description Solid–lipid nanoparticles and nanostructured lipid carriers are delivery systems for the delivery of drugs and other bioactives used in diagnosis, therapy, and treatment procedures. These nanocarriers may enhance the solubility and permeability of drugs, increase their bioavailability, and extend the residence time in the body, combining low toxicity with a targeted delivery. Nanostructured lipid carriers are the second generation of lipid nanoparticles differing from solid lipid nanoparticles in their composition matrix. The use of a liquid lipid together with a solid lipid in nanostructured lipid carrier allows it to load a higher amount of drug, enhance drug release properties, and increase its stability. Therefore, a direct comparison between solid lipid nanoparticles and nanostructured lipid carriers is needed. This review aims to describe solid lipid nanoparticles and nanostructured lipid carriers as drug delivery systems, comparing both, while systematically elucidating their production methodologies, physicochemical characterization, and in vitro and in vivo performance. In addition, the toxicity concerns of these systems are focused on.
publishDate 2023
dc.date.none.fl_str_mv 2023-06-28T09:35:02Z
2023-05-25
2023-06-27T13:21:49Z
2023-05-25T00:00:00Z
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url http://hdl.handle.net/10400.1/19772
dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv Pharmaceutics 15 (6): 1593 (2023)
doi: 10.3390/pharmaceutics15061593
10.3390/pharmaceutics15061593
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