Nucleic acid-based therapy for brain tumor

Detalhes bibliográficos
Autor(a) principal: Zhang, Zixia
Data de Publicação: 2022
Outros Autores: Conniot, João, Amorim, Joana, Jin, Yiliang, Prasad, Rajendra, Yan, Xiyun, Fan, Kelong, Conde, João
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/143307
Resumo: This work was financially supported by the National Key Research and Development Program of China (No. 2021YFA1201102), the European Research Council Starting Grant (ERC-StG-2019-848325 to J. Conde), National Natural Science Foundation of China (No. 82122037, No. 31900981), the Strategic Priority Research Program of CAS (XDB29040101), Youth Innovation Promotion Association of Chinese Academy of Sciences (2019093) and CAS Interdisciplinary Innovation Team (JCTD-2020-08). All figures were created with the aid of BioRender.
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spelling Nucleic acid-based therapy for brain tumorChallenges and strategiesNucleic acid-based therapyBrain tumorBlood brain barrierDrug deliveryCarriersThis work was financially supported by the National Key Research and Development Program of China (No. 2021YFA1201102), the European Research Council Starting Grant (ERC-StG-2019-848325 to J. Conde), National Natural Science Foundation of China (No. 82122037, No. 31900981), the Strategic Priority Research Program of CAS (XDB29040101), Youth Innovation Promotion Association of Chinese Academy of Sciences (2019093) and CAS Interdisciplinary Innovation Team (JCTD-2020-08). All figures were created with the aid of BioRender.Nucleic acid-based therapy emerges as a powerful weapon for the treatment of tumors thanks to its direct, effective, and lasting therapeutic effect. Encouragingly, continuous nucleic acid-based drugs have been approved by the Food and Drug Administration (FDA) and the European Medicines Agency (EMA). Despite the tremendous progress, there are few nucleic acid-based drugs for brain tumors in clinic. The most challenging problems lie on the instability of nucleic acids, difficulty in traversing the biological barriers, and the off-target effect. Herein, nucleic acid-based therapy for brain tumor is summarized considering three aspects: (i) the therapeutic nucleic acids and their applications in clinical trials; (ii) the various administration routes for nucleic acid delivery and the respective advantages and drawbacks. (iii) the strategies and carriers for improving stability and targeting ability of nucleic acid drugs. This review provides thorough knowledge for the rational design of nucleic acid-based drugs against brain tumor.Centre for Toxicogenomics and Human Health (ToxOmics)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNZhang, ZixiaConniot, JoãoAmorim, JoanaJin, YiliangPrasad, RajendraYan, XiyunFan, KelongConde, João2022-08-25T22:21:19Z2022-102022-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/143307eng0168-3659PURE: 46066726https://doi.org/10.1016/j.jconrel.2022.08.014info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:21:37Zoai:run.unl.pt:10362/143307Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:50:49.477827Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Nucleic acid-based therapy for brain tumor
Challenges and strategies
title Nucleic acid-based therapy for brain tumor
spellingShingle Nucleic acid-based therapy for brain tumor
Zhang, Zixia
Nucleic acid-based therapy
Brain tumor
Blood brain barrier
Drug delivery
Carriers
title_short Nucleic acid-based therapy for brain tumor
title_full Nucleic acid-based therapy for brain tumor
title_fullStr Nucleic acid-based therapy for brain tumor
title_full_unstemmed Nucleic acid-based therapy for brain tumor
title_sort Nucleic acid-based therapy for brain tumor
author Zhang, Zixia
author_facet Zhang, Zixia
Conniot, João
Amorim, Joana
Jin, Yiliang
Prasad, Rajendra
Yan, Xiyun
Fan, Kelong
Conde, João
author_role author
author2 Conniot, João
Amorim, Joana
Jin, Yiliang
Prasad, Rajendra
Yan, Xiyun
Fan, Kelong
Conde, João
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Centre for Toxicogenomics and Human Health (ToxOmics)
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Zhang, Zixia
Conniot, João
Amorim, Joana
Jin, Yiliang
Prasad, Rajendra
Yan, Xiyun
Fan, Kelong
Conde, João
dc.subject.por.fl_str_mv Nucleic acid-based therapy
Brain tumor
Blood brain barrier
Drug delivery
Carriers
topic Nucleic acid-based therapy
Brain tumor
Blood brain barrier
Drug delivery
Carriers
description This work was financially supported by the National Key Research and Development Program of China (No. 2021YFA1201102), the European Research Council Starting Grant (ERC-StG-2019-848325 to J. Conde), National Natural Science Foundation of China (No. 82122037, No. 31900981), the Strategic Priority Research Program of CAS (XDB29040101), Youth Innovation Promotion Association of Chinese Academy of Sciences (2019093) and CAS Interdisciplinary Innovation Team (JCTD-2020-08). All figures were created with the aid of BioRender.
publishDate 2022
dc.date.none.fl_str_mv 2022-08-25T22:21:19Z
2022-10
2022-10-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/143307
url http://hdl.handle.net/10362/143307
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0168-3659
PURE: 46066726
https://doi.org/10.1016/j.jconrel.2022.08.014
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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