Biodegradable nanoparticles for the treatment of epilepsy: From current advances to future challenges
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/103889 https://doi.org/10.1002/epi4.12567 |
Resumo: | Epilepsy is the second most prevalent neurological disease worldwide. It is mainly characterized by an electrical abnormal activity in different brain regions. The massive entrance of Ca2+ into neurons is the main neurotoxic process that lead to cell death and finally to neurodegeneration. Although there are a huge number of antiseizure medications, there are many patients who do not respond to the treatments and present refractory epilepsy. In this context, nanomedicine constitutes a promising alternative to enhance the central nervous system bioavailability of antiseizure medications. The encapsulation of different chemical compounds at once in a variety of controlled drug delivery systems gives rise to an enhanced drug effectiveness mainly due to their targeting and penetration into the deepest brain region and the protection of the drug chemical structure. Thus, in this review we will explore the recent advances in the development of drugs associated with polymeric and lipid-based nanocarriers as novel tools for the management of epilepsy disorders. |
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Biodegradable nanoparticles for the treatment of epilepsy: From current advances to future challengesepilepsylipid nanoparticlesnanomedicinenanotechnologyneurodegenerative diseasespolymeric nanoparticlesDrug CarriersDrug Delivery SystemsHumansNanomedicineEpilepsyNanoparticlesEpilepsy is the second most prevalent neurological disease worldwide. It is mainly characterized by an electrical abnormal activity in different brain regions. The massive entrance of Ca2+ into neurons is the main neurotoxic process that lead to cell death and finally to neurodegeneration. Although there are a huge number of antiseizure medications, there are many patients who do not respond to the treatments and present refractory epilepsy. In this context, nanomedicine constitutes a promising alternative to enhance the central nervous system bioavailability of antiseizure medications. The encapsulation of different chemical compounds at once in a variety of controlled drug delivery systems gives rise to an enhanced drug effectiveness mainly due to their targeting and penetration into the deepest brain region and the protection of the drug chemical structure. Thus, in this review we will explore the recent advances in the development of drugs associated with polymeric and lipid-based nanocarriers as novel tools for the management of epilepsy disorders.Wiley-Blackwell2022-08info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/103889http://hdl.handle.net/10316/103889https://doi.org/10.1002/epi4.12567eng2470-92392470-9239Bonilla, LorenaEsteruelas, GerardEttcheto, MirenEspina, MartaGarcía, María LuisaCamins, AntoniSouto, Eliana B.Cano, AmandaSánchez-López, Elenainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-12-07T21:37:23Zoai:estudogeral.uc.pt:10316/103889Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:20:39.217579Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Biodegradable nanoparticles for the treatment of epilepsy: From current advances to future challenges |
title |
Biodegradable nanoparticles for the treatment of epilepsy: From current advances to future challenges |
spellingShingle |
Biodegradable nanoparticles for the treatment of epilepsy: From current advances to future challenges Bonilla, Lorena epilepsy lipid nanoparticles nanomedicine nanotechnology neurodegenerative diseases polymeric nanoparticles Drug Carriers Drug Delivery Systems Humans Nanomedicine Epilepsy Nanoparticles |
title_short |
Biodegradable nanoparticles for the treatment of epilepsy: From current advances to future challenges |
title_full |
Biodegradable nanoparticles for the treatment of epilepsy: From current advances to future challenges |
title_fullStr |
Biodegradable nanoparticles for the treatment of epilepsy: From current advances to future challenges |
title_full_unstemmed |
Biodegradable nanoparticles for the treatment of epilepsy: From current advances to future challenges |
title_sort |
Biodegradable nanoparticles for the treatment of epilepsy: From current advances to future challenges |
author |
Bonilla, Lorena |
author_facet |
Bonilla, Lorena Esteruelas, Gerard Ettcheto, Miren Espina, Marta García, María Luisa Camins, Antoni Souto, Eliana B. Cano, Amanda Sánchez-López, Elena |
author_role |
author |
author2 |
Esteruelas, Gerard Ettcheto, Miren Espina, Marta García, María Luisa Camins, Antoni Souto, Eliana B. Cano, Amanda Sánchez-López, Elena |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Bonilla, Lorena Esteruelas, Gerard Ettcheto, Miren Espina, Marta García, María Luisa Camins, Antoni Souto, Eliana B. Cano, Amanda Sánchez-López, Elena |
dc.subject.por.fl_str_mv |
epilepsy lipid nanoparticles nanomedicine nanotechnology neurodegenerative diseases polymeric nanoparticles Drug Carriers Drug Delivery Systems Humans Nanomedicine Epilepsy Nanoparticles |
topic |
epilepsy lipid nanoparticles nanomedicine nanotechnology neurodegenerative diseases polymeric nanoparticles Drug Carriers Drug Delivery Systems Humans Nanomedicine Epilepsy Nanoparticles |
description |
Epilepsy is the second most prevalent neurological disease worldwide. It is mainly characterized by an electrical abnormal activity in different brain regions. The massive entrance of Ca2+ into neurons is the main neurotoxic process that lead to cell death and finally to neurodegeneration. Although there are a huge number of antiseizure medications, there are many patients who do not respond to the treatments and present refractory epilepsy. In this context, nanomedicine constitutes a promising alternative to enhance the central nervous system bioavailability of antiseizure medications. The encapsulation of different chemical compounds at once in a variety of controlled drug delivery systems gives rise to an enhanced drug effectiveness mainly due to their targeting and penetration into the deepest brain region and the protection of the drug chemical structure. Thus, in this review we will explore the recent advances in the development of drugs associated with polymeric and lipid-based nanocarriers as novel tools for the management of epilepsy disorders. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-08 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/103889 http://hdl.handle.net/10316/103889 https://doi.org/10.1002/epi4.12567 |
url |
http://hdl.handle.net/10316/103889 https://doi.org/10.1002/epi4.12567 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2470-9239 2470-9239 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Wiley-Blackwell |
publisher.none.fl_str_mv |
Wiley-Blackwell |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134098475712512 |