Engineered Saccharomyces cerevisiae for lignocellulosic valorization: a review and perspectives on bioethanol production

Detalhes bibliográficos
Autor(a) principal: Cunha, Joana Filipa Torres Pinheiro
Data de Publicação: 2020
Outros Autores: Soares, Pedro Miguel Oliveira, Baptista, Sara Isabel Leite, Costa, Carlos E., Domingues, Lucília
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/66636
Resumo: The biorefinery concept, consisting in using renewable biomass with economical and energy goals, appeared in response to the ongoing exhaustion of fossil reserves. Bioethanol is the most prominent biofuel and has been considered one of the top chemicals to be obtained from biomass. Saccharomyces cerevisiae, the preferred microorganism for ethanol production, has been the target of extensive genetic modifications to improve the production of this alcohol from renewable biomasses. Additionally, S. cerevisiae strains from harsh industrial environments have been exploited due to their robust traits and improved fermentative capacity. Nevertheless, there is still not an optimized strain capable of turning second generation bioprocesses economically viable. Considering this, and aiming to facilitate and guide the future development of effective S. cerevisiae strains, this work reviews genetic engineering strategies envisioning improvements in 2nd generation bioethanol production, with special focus in process-related traits, xylose consumption, and consolidated bioprocessing. Altogether, the genetic toolbox described proves S. cerevisiae to be a key microorganism for the establishment of a bioeconomy, not only for the production of lignocellulosic bioethanol, but also having potential as a cell factory platform for overall valorization of renewable biomasses.
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spelling Engineered Saccharomyces cerevisiae for lignocellulosic valorization: a review and perspectives on bioethanol productionSaccharomyces cerevisiaegenetic engineering2nd generation bioethanolbiorefinerieslignocellulosic biomass2 generation bioethanol ndScience & TechnologyThe biorefinery concept, consisting in using renewable biomass with economical and energy goals, appeared in response to the ongoing exhaustion of fossil reserves. Bioethanol is the most prominent biofuel and has been considered one of the top chemicals to be obtained from biomass. Saccharomyces cerevisiae, the preferred microorganism for ethanol production, has been the target of extensive genetic modifications to improve the production of this alcohol from renewable biomasses. Additionally, S. cerevisiae strains from harsh industrial environments have been exploited due to their robust traits and improved fermentative capacity. Nevertheless, there is still not an optimized strain capable of turning second generation bioprocesses economically viable. Considering this, and aiming to facilitate and guide the future development of effective S. cerevisiae strains, this work reviews genetic engineering strategies envisioning improvements in 2nd generation bioethanol production, with special focus in process-related traits, xylose consumption, and consolidated bioprocessing. Altogether, the genetic toolbox described proves S. cerevisiae to be a key microorganism for the establishment of a bioeconomy, not only for the production of lignocellulosic bioethanol, but also having potential as a cell factory platform for overall valorization of renewable biomasses.This work was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UIDB/04469/2020, the PhD grants [SFRH/BD/ 130739/2017 to CEC; SFRH/BD/146367/2019 to POS; SFRH/ BD/132717/2017 to SLB], the MIT-Portugal Program [PhD Grant PD/BD/128247/2016 to JTC], BioTecNorte operation [NORTE-01-0145-FEDER-000004] and Biomass and Bioenergy Research Infrastructure (BBRI)- LISBOA-01-0145-FEDER- 022059] funded by the European Regional Development Fund (ERDF) under the scope of Norte2020 - Programa Operacional Regional do Norte.info:eu-repo/semantics/publishedVersionTaylor and FrancisUniversidade do MinhoCunha, Joana Filipa Torres PinheiroSoares, Pedro Miguel OliveiraBaptista, Sara Isabel LeiteCosta, Carlos E.Domingues, Lucília20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/66636engCunha, Joana T.; Soares, P.; Sara Baptista; Costa, Carlos E.; Domingues, Lucília, Engineered Saccharomyces cerevisiae for lignocellulosic valorization: a review and perspectives on bioethanol production. Bioengineered, 11(1), 883-903, 20202165-59792165-598710.1080/21655979.2020.180117832799606http://www.tandfonline.com/toc/kbie20/currentinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-11T07:02:09Zoai:repositorium.sdum.uminho.pt:1822/66636Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-11T07:02:09Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Engineered Saccharomyces cerevisiae for lignocellulosic valorization: a review and perspectives on bioethanol production
title Engineered Saccharomyces cerevisiae for lignocellulosic valorization: a review and perspectives on bioethanol production
spellingShingle Engineered Saccharomyces cerevisiae for lignocellulosic valorization: a review and perspectives on bioethanol production
Cunha, Joana Filipa Torres Pinheiro
Saccharomyces cerevisiae
genetic engineering
2nd generation bioethanol
biorefineries
lignocellulosic biomass
2 generation bioethanol nd
Science & Technology
title_short Engineered Saccharomyces cerevisiae for lignocellulosic valorization: a review and perspectives on bioethanol production
title_full Engineered Saccharomyces cerevisiae for lignocellulosic valorization: a review and perspectives on bioethanol production
title_fullStr Engineered Saccharomyces cerevisiae for lignocellulosic valorization: a review and perspectives on bioethanol production
title_full_unstemmed Engineered Saccharomyces cerevisiae for lignocellulosic valorization: a review and perspectives on bioethanol production
title_sort Engineered Saccharomyces cerevisiae for lignocellulosic valorization: a review and perspectives on bioethanol production
author Cunha, Joana Filipa Torres Pinheiro
author_facet Cunha, Joana Filipa Torres Pinheiro
Soares, Pedro Miguel Oliveira
Baptista, Sara Isabel Leite
Costa, Carlos E.
Domingues, Lucília
author_role author
author2 Soares, Pedro Miguel Oliveira
Baptista, Sara Isabel Leite
Costa, Carlos E.
Domingues, Lucília
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Cunha, Joana Filipa Torres Pinheiro
Soares, Pedro Miguel Oliveira
Baptista, Sara Isabel Leite
Costa, Carlos E.
Domingues, Lucília
dc.subject.por.fl_str_mv Saccharomyces cerevisiae
genetic engineering
2nd generation bioethanol
biorefineries
lignocellulosic biomass
2 generation bioethanol nd
Science & Technology
topic Saccharomyces cerevisiae
genetic engineering
2nd generation bioethanol
biorefineries
lignocellulosic biomass
2 generation bioethanol nd
Science & Technology
description The biorefinery concept, consisting in using renewable biomass with economical and energy goals, appeared in response to the ongoing exhaustion of fossil reserves. Bioethanol is the most prominent biofuel and has been considered one of the top chemicals to be obtained from biomass. Saccharomyces cerevisiae, the preferred microorganism for ethanol production, has been the target of extensive genetic modifications to improve the production of this alcohol from renewable biomasses. Additionally, S. cerevisiae strains from harsh industrial environments have been exploited due to their robust traits and improved fermentative capacity. Nevertheless, there is still not an optimized strain capable of turning second generation bioprocesses economically viable. Considering this, and aiming to facilitate and guide the future development of effective S. cerevisiae strains, this work reviews genetic engineering strategies envisioning improvements in 2nd generation bioethanol production, with special focus in process-related traits, xylose consumption, and consolidated bioprocessing. Altogether, the genetic toolbox described proves S. cerevisiae to be a key microorganism for the establishment of a bioeconomy, not only for the production of lignocellulosic bioethanol, but also having potential as a cell factory platform for overall valorization of renewable biomasses.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/66636
url http://hdl.handle.net/1822/66636
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Cunha, Joana T.; Soares, P.; Sara Baptista; Costa, Carlos E.; Domingues, Lucília, Engineered Saccharomyces cerevisiae for lignocellulosic valorization: a review and perspectives on bioethanol production. Bioengineered, 11(1), 883-903, 2020
2165-5979
2165-5987
10.1080/21655979.2020.1801178
32799606
http://www.tandfonline.com/toc/kbie20/current
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor and Francis
publisher.none.fl_str_mv Taylor and Francis
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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