Genetic diversity and signatures of selection of drug resistance in Plasmodium populations from both human and mosquito hosts in continental Equatorial Guinea

Detalhes bibliográficos
Autor(a) principal: Mendes, Cristina
Data de Publicação: 2013
Outros Autores: Salgueiro, Patrícia, Gonzalez, Vicenta, Berzosa, Pedro, Benito, Agustin, Rosário, Virgílio E. do, Sousa, Bruno de, Cano, Jorge, Arez, Ana Paula
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/46917
https://doi.org/10.1186/1475-2875-12-114
Resumo: In Plasmodium, the high level of genetic diversity and the interactions established by co-infecting parasite populations within the same host may be a source of selection on pathogen virulence and drug resistance. As different patterns have already been described in humans and mosquitoes, parasite diversity and population structure should be studied in both hosts to properly assess their effects on infection and transmission dynamics. This study aimed to characterize the circulating populations of Plasmodium spp and Plasmodium falciparum from a combined set of human blood and mosquito samples gathered in mainland Equatorial Guinea. Further, the origin and evolution of anti-malarial resistance in this area, where malaria remains a major public health problem were traced.
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spelling Genetic diversity and signatures of selection of drug resistance in Plasmodium populations from both human and mosquito hosts in continental Equatorial GuineaAdolescentAdultAgedAnimalsAntimalarialsChildChild, PreschoolCulicidaeDNA, ProtozoanEquatorial GuineaFemaleGenes, ProtozoanHumansInfantMalariaMaleMiddle AgedPlasmodiumPoint MutationPolymerase Chain ReactionSelection, GeneticYoung AdultDrug ResistanceGenetic MarkersGenetic VariationIn Plasmodium, the high level of genetic diversity and the interactions established by co-infecting parasite populations within the same host may be a source of selection on pathogen virulence and drug resistance. As different patterns have already been described in humans and mosquitoes, parasite diversity and population structure should be studied in both hosts to properly assess their effects on infection and transmission dynamics. This study aimed to characterize the circulating populations of Plasmodium spp and Plasmodium falciparum from a combined set of human blood and mosquito samples gathered in mainland Equatorial Guinea. Further, the origin and evolution of anti-malarial resistance in this area, where malaria remains a major public health problem were traced.2013info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/46917http://hdl.handle.net/10316/46917https://doi.org/10.1186/1475-2875-12-114porMendes, CristinaSalgueiro, PatríciaGonzalez, VicentaBerzosa, PedroBenito, AgustinRosário, Virgílio E. doSousa, Bruno deCano, JorgeArez, Ana Paulainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-08-24T10:25:07Zoai:estudogeral.uc.pt:10316/46917Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:53:00.698351Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Genetic diversity and signatures of selection of drug resistance in Plasmodium populations from both human and mosquito hosts in continental Equatorial Guinea
title Genetic diversity and signatures of selection of drug resistance in Plasmodium populations from both human and mosquito hosts in continental Equatorial Guinea
spellingShingle Genetic diversity and signatures of selection of drug resistance in Plasmodium populations from both human and mosquito hosts in continental Equatorial Guinea
Mendes, Cristina
Adolescent
Adult
Aged
Animals
Antimalarials
Child
Child, Preschool
Culicidae
DNA, Protozoan
Equatorial Guinea
Female
Genes, Protozoan
Humans
Infant
Malaria
Male
Middle Aged
Plasmodium
Point Mutation
Polymerase Chain Reaction
Selection, Genetic
Young Adult
Drug Resistance
Genetic Markers
Genetic Variation
title_short Genetic diversity and signatures of selection of drug resistance in Plasmodium populations from both human and mosquito hosts in continental Equatorial Guinea
title_full Genetic diversity and signatures of selection of drug resistance in Plasmodium populations from both human and mosquito hosts in continental Equatorial Guinea
title_fullStr Genetic diversity and signatures of selection of drug resistance in Plasmodium populations from both human and mosquito hosts in continental Equatorial Guinea
title_full_unstemmed Genetic diversity and signatures of selection of drug resistance in Plasmodium populations from both human and mosquito hosts in continental Equatorial Guinea
title_sort Genetic diversity and signatures of selection of drug resistance in Plasmodium populations from both human and mosquito hosts in continental Equatorial Guinea
author Mendes, Cristina
author_facet Mendes, Cristina
Salgueiro, Patrícia
Gonzalez, Vicenta
Berzosa, Pedro
Benito, Agustin
Rosário, Virgílio E. do
Sousa, Bruno de
Cano, Jorge
Arez, Ana Paula
author_role author
author2 Salgueiro, Patrícia
Gonzalez, Vicenta
Berzosa, Pedro
Benito, Agustin
Rosário, Virgílio E. do
Sousa, Bruno de
Cano, Jorge
Arez, Ana Paula
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Mendes, Cristina
Salgueiro, Patrícia
Gonzalez, Vicenta
Berzosa, Pedro
Benito, Agustin
Rosário, Virgílio E. do
Sousa, Bruno de
Cano, Jorge
Arez, Ana Paula
dc.subject.por.fl_str_mv Adolescent
Adult
Aged
Animals
Antimalarials
Child
Child, Preschool
Culicidae
DNA, Protozoan
Equatorial Guinea
Female
Genes, Protozoan
Humans
Infant
Malaria
Male
Middle Aged
Plasmodium
Point Mutation
Polymerase Chain Reaction
Selection, Genetic
Young Adult
Drug Resistance
Genetic Markers
Genetic Variation
topic Adolescent
Adult
Aged
Animals
Antimalarials
Child
Child, Preschool
Culicidae
DNA, Protozoan
Equatorial Guinea
Female
Genes, Protozoan
Humans
Infant
Malaria
Male
Middle Aged
Plasmodium
Point Mutation
Polymerase Chain Reaction
Selection, Genetic
Young Adult
Drug Resistance
Genetic Markers
Genetic Variation
description In Plasmodium, the high level of genetic diversity and the interactions established by co-infecting parasite populations within the same host may be a source of selection on pathogen virulence and drug resistance. As different patterns have already been described in humans and mosquitoes, parasite diversity and population structure should be studied in both hosts to properly assess their effects on infection and transmission dynamics. This study aimed to characterize the circulating populations of Plasmodium spp and Plasmodium falciparum from a combined set of human blood and mosquito samples gathered in mainland Equatorial Guinea. Further, the origin and evolution of anti-malarial resistance in this area, where malaria remains a major public health problem were traced.
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/46917
http://hdl.handle.net/10316/46917
https://doi.org/10.1186/1475-2875-12-114
url http://hdl.handle.net/10316/46917
https://doi.org/10.1186/1475-2875-12-114
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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