Whole organic electronic synapses for dopamine detection

Detalhes bibliográficos
Autor(a) principal: Giordani, Martina
Data de Publicação: 2016
Outros Autores: Di Lauro, Michele, Berto, Marcello, Bortolotti, Carlo A., Vuillaume, Dominique, Gomes, Henrique L., Zoli, Michele, Biscarini, Fabio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.1/9669
Resumo: A whole organic artificial synapse has been fabricated by patterning PEDOT:PSS electrodes on PDMS that are biased in frequency to yield a STP response. The timescale of the STP response is shown to be sensitive to the concentration of dopamine, DA, a neurotransmitter relevant for monitoring the development of Parkinson's disease and potential locoregional therapies. The sensitivity of the sensor towards DA has been validated comparing signal variation in the presence of DA and its principal interfering agent, ascorbic acid, AA. The whole organic synapse is biocompatible, soft and flexible, and is attractive for implantable devices aimed to real-time monitoring of DA concentration in bodily fluids. This may open applications in chronic neurodegenerative diseases such as Parkinson's disease.
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spelling Whole organic electronic synapses for dopamine detectionA whole organic artificial synapse has been fabricated by patterning PEDOT:PSS electrodes on PDMS that are biased in frequency to yield a STP response. The timescale of the STP response is shown to be sensitive to the concentration of dopamine, DA, a neurotransmitter relevant for monitoring the development of Parkinson's disease and potential locoregional therapies. The sensitivity of the sensor towards DA has been validated comparing signal variation in the presence of DA and its principal interfering agent, ascorbic acid, AA. The whole organic synapse is biocompatible, soft and flexible, and is attractive for implantable devices aimed to real-time monitoring of DA concentration in bodily fluids. This may open applications in chronic neurodegenerative diseases such as Parkinson's disease.EU 7th Framework Programme [FP7/2007–2013]; Grant Agreement No. 280772; IT MIUR Bilateral Project IT/SE “Poincaré”SPIESapientiaGiordani, MartinaDi Lauro, MicheleBerto, MarcelloBortolotti, Carlo A.Vuillaume, DominiqueGomes, Henrique L.Zoli, MicheleBiscarini, Fabio2017-04-07T15:57:18Z20162016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/9669eng978-1-5106-0280-90277-786XAUT: HGO00803;10.1117/12.2239532info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:21:10Zoai:sapientia.ualg.pt:10400.1/9669Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:01:33.512707Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Whole organic electronic synapses for dopamine detection
title Whole organic electronic synapses for dopamine detection
spellingShingle Whole organic electronic synapses for dopamine detection
Giordani, Martina
title_short Whole organic electronic synapses for dopamine detection
title_full Whole organic electronic synapses for dopamine detection
title_fullStr Whole organic electronic synapses for dopamine detection
title_full_unstemmed Whole organic electronic synapses for dopamine detection
title_sort Whole organic electronic synapses for dopamine detection
author Giordani, Martina
author_facet Giordani, Martina
Di Lauro, Michele
Berto, Marcello
Bortolotti, Carlo A.
Vuillaume, Dominique
Gomes, Henrique L.
Zoli, Michele
Biscarini, Fabio
author_role author
author2 Di Lauro, Michele
Berto, Marcello
Bortolotti, Carlo A.
Vuillaume, Dominique
Gomes, Henrique L.
Zoli, Michele
Biscarini, Fabio
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Sapientia
dc.contributor.author.fl_str_mv Giordani, Martina
Di Lauro, Michele
Berto, Marcello
Bortolotti, Carlo A.
Vuillaume, Dominique
Gomes, Henrique L.
Zoli, Michele
Biscarini, Fabio
description A whole organic artificial synapse has been fabricated by patterning PEDOT:PSS electrodes on PDMS that are biased in frequency to yield a STP response. The timescale of the STP response is shown to be sensitive to the concentration of dopamine, DA, a neurotransmitter relevant for monitoring the development of Parkinson's disease and potential locoregional therapies. The sensitivity of the sensor towards DA has been validated comparing signal variation in the presence of DA and its principal interfering agent, ascorbic acid, AA. The whole organic synapse is biocompatible, soft and flexible, and is attractive for implantable devices aimed to real-time monitoring of DA concentration in bodily fluids. This may open applications in chronic neurodegenerative diseases such as Parkinson's disease.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-01-01T00:00:00Z
2017-04-07T15:57:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.1/9669
url http://hdl.handle.net/10400.1/9669
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 978-1-5106-0280-9
0277-786X
AUT: HGO00803;
10.1117/12.2239532
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv SPIE
publisher.none.fl_str_mv SPIE
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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