Body Composition of Infants Born with Intrauterine Growth Restriction: A Systematic Review and Meta-Analysis
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.17/4005 |
Resumo: | Intrauterine growth restriction (IUGR) may predispose metabolic diseases in later life. Changes in fat-free mass (FFM) and fat mass (FM) may explain this metabolic risk. This review studied the effect of IUGR on body composition in early infancy. Five databases and included studies from all countries published from 2000 until August 2021 were searched. Participants were IUGR or small-for-gestational age (SGA) infants, and the primary outcomes were FFM and FM. Eighteen studies met the inclusion criteria, of which seven were included in the meta-analysis of primary outcomes. Overall, intrauterine growth-restricted and SGA infants were lighter and shorter than normal intrauterine growth and appropriate-for-gestational age infants, respectively, from birth to the latest follow up. They had lower FFM [mean difference -429.19 (p = 0.02)] and FM [mean difference -282.9 (p < 0.001)]. The issue of whether lower FFM and FM as reasons for future metabolic risk in IUGR infants is intriguing which could be explored in further research with longer follow-up. This review, the first of its kind can be useful for developing nutrition targeted interventions for IUGR infants in future. |
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Body Composition of Infants Born with Intrauterine Growth Restriction: A Systematic Review and Meta-AnalysisAdiposityBody compositionFat-free massFetal growthIntrauterine growth restrictionSmall-for-gestational ageHDE UCI NEOIntrauterine growth restriction (IUGR) may predispose metabolic diseases in later life. Changes in fat-free mass (FFM) and fat mass (FM) may explain this metabolic risk. This review studied the effect of IUGR on body composition in early infancy. Five databases and included studies from all countries published from 2000 until August 2021 were searched. Participants were IUGR or small-for-gestational age (SGA) infants, and the primary outcomes were FFM and FM. Eighteen studies met the inclusion criteria, of which seven were included in the meta-analysis of primary outcomes. Overall, intrauterine growth-restricted and SGA infants were lighter and shorter than normal intrauterine growth and appropriate-for-gestational age infants, respectively, from birth to the latest follow up. They had lower FFM [mean difference -429.19 (p = 0.02)] and FM [mean difference -282.9 (p < 0.001)]. The issue of whether lower FFM and FM as reasons for future metabolic risk in IUGR infants is intriguing which could be explored in further research with longer follow-up. This review, the first of its kind can be useful for developing nutrition targeted interventions for IUGR infants in future.Multidisciplinary Digital Publishing Institute (MDPI)Repositório do Centro Hospitalar Universitário de Lisboa Central, EPEManapurath, RGadapani, BPereira-da-Silva, L2022-03-15T15:42:47Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/4005engNutrients . 2022 Mar 4;14(5):108510.3390/nu14051085info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:44:55Zoai:repositorio.chlc.min-saude.pt:10400.17/4005Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:21:18.773828Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Body Composition of Infants Born with Intrauterine Growth Restriction: A Systematic Review and Meta-Analysis |
title |
Body Composition of Infants Born with Intrauterine Growth Restriction: A Systematic Review and Meta-Analysis |
spellingShingle |
Body Composition of Infants Born with Intrauterine Growth Restriction: A Systematic Review and Meta-Analysis Manapurath, R Adiposity Body composition Fat-free mass Fetal growth Intrauterine growth restriction Small-for-gestational age HDE UCI NEO |
title_short |
Body Composition of Infants Born with Intrauterine Growth Restriction: A Systematic Review and Meta-Analysis |
title_full |
Body Composition of Infants Born with Intrauterine Growth Restriction: A Systematic Review and Meta-Analysis |
title_fullStr |
Body Composition of Infants Born with Intrauterine Growth Restriction: A Systematic Review and Meta-Analysis |
title_full_unstemmed |
Body Composition of Infants Born with Intrauterine Growth Restriction: A Systematic Review and Meta-Analysis |
title_sort |
Body Composition of Infants Born with Intrauterine Growth Restriction: A Systematic Review and Meta-Analysis |
author |
Manapurath, R |
author_facet |
Manapurath, R Gadapani, B Pereira-da-Silva, L |
author_role |
author |
author2 |
Gadapani, B Pereira-da-Silva, L |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE |
dc.contributor.author.fl_str_mv |
Manapurath, R Gadapani, B Pereira-da-Silva, L |
dc.subject.por.fl_str_mv |
Adiposity Body composition Fat-free mass Fetal growth Intrauterine growth restriction Small-for-gestational age HDE UCI NEO |
topic |
Adiposity Body composition Fat-free mass Fetal growth Intrauterine growth restriction Small-for-gestational age HDE UCI NEO |
description |
Intrauterine growth restriction (IUGR) may predispose metabolic diseases in later life. Changes in fat-free mass (FFM) and fat mass (FM) may explain this metabolic risk. This review studied the effect of IUGR on body composition in early infancy. Five databases and included studies from all countries published from 2000 until August 2021 were searched. Participants were IUGR or small-for-gestational age (SGA) infants, and the primary outcomes were FFM and FM. Eighteen studies met the inclusion criteria, of which seven were included in the meta-analysis of primary outcomes. Overall, intrauterine growth-restricted and SGA infants were lighter and shorter than normal intrauterine growth and appropriate-for-gestational age infants, respectively, from birth to the latest follow up. They had lower FFM [mean difference -429.19 (p = 0.02)] and FM [mean difference -282.9 (p < 0.001)]. The issue of whether lower FFM and FM as reasons for future metabolic risk in IUGR infants is intriguing which could be explored in further research with longer follow-up. This review, the first of its kind can be useful for developing nutrition targeted interventions for IUGR infants in future. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-03-15T15:42:47Z 2022 2022-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.17/4005 |
url |
http://hdl.handle.net/10400.17/4005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Nutrients . 2022 Mar 4;14(5):1085 10.3390/nu14051085 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute (MDPI) |
publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute (MDPI) |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799131309259358208 |