Valuing the endangered species Antirrhinum lopesianum

Detalhes bibliográficos
Autor(a) principal: Gomes, Andreia
Data de Publicação: 2013
Outros Autores: Fortalezas, Sofia, Pimpão, Rui, Figueira, Inês, Maroco, João, Aguiar, Carlos, Ferreira, Ricardo B., Miguel, Célia, Santos, Cláudia N.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.3390/antiox2040273
Resumo: Plant phytochemicals are described as possessing considerable neuroprotective properties, due to radical scavenging capacity and acetylcholinesterase inhibitory activity, important bioactivities in neurodegeneration. Antirrhinum lopesianum is a rare endemism from the Iberian Peninsula, occurring at the northeastern border between Portugal and Spain. It is classified as Endangered, due to its highly fragmented geographical occupation, facing a high risk of extinction in the Portuguese territory, within 20 years. Here, we describe for the first time the chemical characterization of extracts of the species concerning total phenol content, flavonoid content and antioxidant properties. The profile of high performance liquid chromatography with diode array detector (HPLC-DAD) of the polyphenol-enriched fraction of plant extracts was also performed, showing the great potential of the species as a source of bioactive phytochemical compounds. A. lopesianum’s potential for neuroprotection was revealed by a significant acetylcholinesterase inhibitory activity and also by a neuroprotective effect on a human cell model of neurodegeneration. Moreover, this is the first report describing a successful procedure for the in vitro propagation of this endangered species. The comparison of phenolic content and the HPLC-DAD profile of wild and in vitro propagated plants revealed that in vitro plants maintain the ability to produce secondary metabolites, but the profiles are differentially affected by the growth regulators. The results presented here greatly contribute to the value for this species regarding its potential as a source of phytochemicals with prospective neuroprotective health benefits.
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spelling Valuing the endangered species Antirrhinum lopesianumNeuroprotective activities and strategies for in vitro plant propagationAcetylcholinesterase inhibitorAntioxidant capacityAntirrhinum lopesianumEx situ conservationNeuroprotectionPhytochemical profilePhysiologyBiochemistryMolecular BiologyClinical BiochemistryCell BiologySDG 3 - Good Health and Well-beingPlant phytochemicals are described as possessing considerable neuroprotective properties, due to radical scavenging capacity and acetylcholinesterase inhibitory activity, important bioactivities in neurodegeneration. Antirrhinum lopesianum is a rare endemism from the Iberian Peninsula, occurring at the northeastern border between Portugal and Spain. It is classified as Endangered, due to its highly fragmented geographical occupation, facing a high risk of extinction in the Portuguese territory, within 20 years. Here, we describe for the first time the chemical characterization of extracts of the species concerning total phenol content, flavonoid content and antioxidant properties. The profile of high performance liquid chromatography with diode array detector (HPLC-DAD) of the polyphenol-enriched fraction of plant extracts was also performed, showing the great potential of the species as a source of bioactive phytochemical compounds. A. lopesianum’s potential for neuroprotection was revealed by a significant acetylcholinesterase inhibitory activity and also by a neuroprotective effect on a human cell model of neurodegeneration. Moreover, this is the first report describing a successful procedure for the in vitro propagation of this endangered species. The comparison of phenolic content and the HPLC-DAD profile of wild and in vitro propagated plants revealed that in vitro plants maintain the ability to produce secondary metabolites, but the profiles are differentially affected by the growth regulators. The results presented here greatly contribute to the value for this species regarding its potential as a source of phytochemicals with prospective neuroprotective health benefits.Instituto de Tecnologia Química e Biológica António Xavier (ITQB)RUNGomes, AndreiaFortalezas, SofiaPimpão, RuiFigueira, InêsMaroco, JoãoAguiar, CarlosFerreira, Ricardo B.Miguel, CéliaSantos, Cláudia N.2019-07-29T22:42:07Z2013-12-012013-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article20application/pdfhttps://doi.org/10.3390/antiox2040273engPURE: 14287528http://www.scopus.com/inward/record.url?scp=84930935929&partnerID=8YFLogxKhttps://doi.org/10.3390/antiox2040273info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:34:59Zoai:run.unl.pt:10362/76922Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:35:42.806682Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Valuing the endangered species Antirrhinum lopesianum
Neuroprotective activities and strategies for in vitro plant propagation
title Valuing the endangered species Antirrhinum lopesianum
spellingShingle Valuing the endangered species Antirrhinum lopesianum
Gomes, Andreia
Acetylcholinesterase inhibitor
Antioxidant capacity
Antirrhinum lopesianum
Ex situ conservation
Neuroprotection
Phytochemical profile
Physiology
Biochemistry
Molecular Biology
Clinical Biochemistry
Cell Biology
SDG 3 - Good Health and Well-being
title_short Valuing the endangered species Antirrhinum lopesianum
title_full Valuing the endangered species Antirrhinum lopesianum
title_fullStr Valuing the endangered species Antirrhinum lopesianum
title_full_unstemmed Valuing the endangered species Antirrhinum lopesianum
title_sort Valuing the endangered species Antirrhinum lopesianum
author Gomes, Andreia
author_facet Gomes, Andreia
Fortalezas, Sofia
Pimpão, Rui
Figueira, Inês
Maroco, João
Aguiar, Carlos
Ferreira, Ricardo B.
Miguel, Célia
Santos, Cláudia N.
author_role author
author2 Fortalezas, Sofia
Pimpão, Rui
Figueira, Inês
Maroco, João
Aguiar, Carlos
Ferreira, Ricardo B.
Miguel, Célia
Santos, Cláudia N.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Tecnologia Química e Biológica António Xavier (ITQB)
RUN
dc.contributor.author.fl_str_mv Gomes, Andreia
Fortalezas, Sofia
Pimpão, Rui
Figueira, Inês
Maroco, João
Aguiar, Carlos
Ferreira, Ricardo B.
Miguel, Célia
Santos, Cláudia N.
dc.subject.por.fl_str_mv Acetylcholinesterase inhibitor
Antioxidant capacity
Antirrhinum lopesianum
Ex situ conservation
Neuroprotection
Phytochemical profile
Physiology
Biochemistry
Molecular Biology
Clinical Biochemistry
Cell Biology
SDG 3 - Good Health and Well-being
topic Acetylcholinesterase inhibitor
Antioxidant capacity
Antirrhinum lopesianum
Ex situ conservation
Neuroprotection
Phytochemical profile
Physiology
Biochemistry
Molecular Biology
Clinical Biochemistry
Cell Biology
SDG 3 - Good Health and Well-being
description Plant phytochemicals are described as possessing considerable neuroprotective properties, due to radical scavenging capacity and acetylcholinesterase inhibitory activity, important bioactivities in neurodegeneration. Antirrhinum lopesianum is a rare endemism from the Iberian Peninsula, occurring at the northeastern border between Portugal and Spain. It is classified as Endangered, due to its highly fragmented geographical occupation, facing a high risk of extinction in the Portuguese territory, within 20 years. Here, we describe for the first time the chemical characterization of extracts of the species concerning total phenol content, flavonoid content and antioxidant properties. The profile of high performance liquid chromatography with diode array detector (HPLC-DAD) of the polyphenol-enriched fraction of plant extracts was also performed, showing the great potential of the species as a source of bioactive phytochemical compounds. A. lopesianum’s potential for neuroprotection was revealed by a significant acetylcholinesterase inhibitory activity and also by a neuroprotective effect on a human cell model of neurodegeneration. Moreover, this is the first report describing a successful procedure for the in vitro propagation of this endangered species. The comparison of phenolic content and the HPLC-DAD profile of wild and in vitro propagated plants revealed that in vitro plants maintain the ability to produce secondary metabolites, but the profiles are differentially affected by the growth regulators. The results presented here greatly contribute to the value for this species regarding its potential as a source of phytochemicals with prospective neuroprotective health benefits.
publishDate 2013
dc.date.none.fl_str_mv 2013-12-01
2013-12-01T00:00:00Z
2019-07-29T22:42:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv https://doi.org/10.3390/antiox2040273
url https://doi.org/10.3390/antiox2040273
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv PURE: 14287528
http://www.scopus.com/inward/record.url?scp=84930935929&partnerID=8YFLogxK
https://doi.org/10.3390/antiox2040273
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eu_rights_str_mv openAccess
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dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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