Valuing the endangered species Antirrhinum lopesianum
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.3390/antiox2040273 |
Resumo: | Plant phytochemicals are described as possessing considerable neuroprotective properties, due to radical scavenging capacity and acetylcholinesterase inhibitory activity, important bioactivities in neurodegeneration. Antirrhinum lopesianum is a rare endemism from the Iberian Peninsula, occurring at the northeastern border between Portugal and Spain. It is classified as Endangered, due to its highly fragmented geographical occupation, facing a high risk of extinction in the Portuguese territory, within 20 years. Here, we describe for the first time the chemical characterization of extracts of the species concerning total phenol content, flavonoid content and antioxidant properties. The profile of high performance liquid chromatography with diode array detector (HPLC-DAD) of the polyphenol-enriched fraction of plant extracts was also performed, showing the great potential of the species as a source of bioactive phytochemical compounds. A. lopesianum’s potential for neuroprotection was revealed by a significant acetylcholinesterase inhibitory activity and also by a neuroprotective effect on a human cell model of neurodegeneration. Moreover, this is the first report describing a successful procedure for the in vitro propagation of this endangered species. The comparison of phenolic content and the HPLC-DAD profile of wild and in vitro propagated plants revealed that in vitro plants maintain the ability to produce secondary metabolites, but the profiles are differentially affected by the growth regulators. The results presented here greatly contribute to the value for this species regarding its potential as a source of phytochemicals with prospective neuroprotective health benefits. |
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Valuing the endangered species Antirrhinum lopesianumNeuroprotective activities and strategies for in vitro plant propagationAcetylcholinesterase inhibitorAntioxidant capacityAntirrhinum lopesianumEx situ conservationNeuroprotectionPhytochemical profilePhysiologyBiochemistryMolecular BiologyClinical BiochemistryCell BiologySDG 3 - Good Health and Well-beingPlant phytochemicals are described as possessing considerable neuroprotective properties, due to radical scavenging capacity and acetylcholinesterase inhibitory activity, important bioactivities in neurodegeneration. Antirrhinum lopesianum is a rare endemism from the Iberian Peninsula, occurring at the northeastern border between Portugal and Spain. It is classified as Endangered, due to its highly fragmented geographical occupation, facing a high risk of extinction in the Portuguese territory, within 20 years. Here, we describe for the first time the chemical characterization of extracts of the species concerning total phenol content, flavonoid content and antioxidant properties. The profile of high performance liquid chromatography with diode array detector (HPLC-DAD) of the polyphenol-enriched fraction of plant extracts was also performed, showing the great potential of the species as a source of bioactive phytochemical compounds. A. lopesianum’s potential for neuroprotection was revealed by a significant acetylcholinesterase inhibitory activity and also by a neuroprotective effect on a human cell model of neurodegeneration. Moreover, this is the first report describing a successful procedure for the in vitro propagation of this endangered species. The comparison of phenolic content and the HPLC-DAD profile of wild and in vitro propagated plants revealed that in vitro plants maintain the ability to produce secondary metabolites, but the profiles are differentially affected by the growth regulators. The results presented here greatly contribute to the value for this species regarding its potential as a source of phytochemicals with prospective neuroprotective health benefits.Instituto de Tecnologia Química e Biológica António Xavier (ITQB)RUNGomes, AndreiaFortalezas, SofiaPimpão, RuiFigueira, InêsMaroco, JoãoAguiar, CarlosFerreira, Ricardo B.Miguel, CéliaSantos, Cláudia N.2019-07-29T22:42:07Z2013-12-012013-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article20application/pdfhttps://doi.org/10.3390/antiox2040273engPURE: 14287528http://www.scopus.com/inward/record.url?scp=84930935929&partnerID=8YFLogxKhttps://doi.org/10.3390/antiox2040273info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:34:59Zoai:run.unl.pt:10362/76922Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:35:42.806682Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Valuing the endangered species Antirrhinum lopesianum Neuroprotective activities and strategies for in vitro plant propagation |
title |
Valuing the endangered species Antirrhinum lopesianum |
spellingShingle |
Valuing the endangered species Antirrhinum lopesianum Gomes, Andreia Acetylcholinesterase inhibitor Antioxidant capacity Antirrhinum lopesianum Ex situ conservation Neuroprotection Phytochemical profile Physiology Biochemistry Molecular Biology Clinical Biochemistry Cell Biology SDG 3 - Good Health and Well-being |
title_short |
Valuing the endangered species Antirrhinum lopesianum |
title_full |
Valuing the endangered species Antirrhinum lopesianum |
title_fullStr |
Valuing the endangered species Antirrhinum lopesianum |
title_full_unstemmed |
Valuing the endangered species Antirrhinum lopesianum |
title_sort |
Valuing the endangered species Antirrhinum lopesianum |
author |
Gomes, Andreia |
author_facet |
Gomes, Andreia Fortalezas, Sofia Pimpão, Rui Figueira, Inês Maroco, João Aguiar, Carlos Ferreira, Ricardo B. Miguel, Célia Santos, Cláudia N. |
author_role |
author |
author2 |
Fortalezas, Sofia Pimpão, Rui Figueira, Inês Maroco, João Aguiar, Carlos Ferreira, Ricardo B. Miguel, Célia Santos, Cláudia N. |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Instituto de Tecnologia Química e Biológica António Xavier (ITQB) RUN |
dc.contributor.author.fl_str_mv |
Gomes, Andreia Fortalezas, Sofia Pimpão, Rui Figueira, Inês Maroco, João Aguiar, Carlos Ferreira, Ricardo B. Miguel, Célia Santos, Cláudia N. |
dc.subject.por.fl_str_mv |
Acetylcholinesterase inhibitor Antioxidant capacity Antirrhinum lopesianum Ex situ conservation Neuroprotection Phytochemical profile Physiology Biochemistry Molecular Biology Clinical Biochemistry Cell Biology SDG 3 - Good Health and Well-being |
topic |
Acetylcholinesterase inhibitor Antioxidant capacity Antirrhinum lopesianum Ex situ conservation Neuroprotection Phytochemical profile Physiology Biochemistry Molecular Biology Clinical Biochemistry Cell Biology SDG 3 - Good Health and Well-being |
description |
Plant phytochemicals are described as possessing considerable neuroprotective properties, due to radical scavenging capacity and acetylcholinesterase inhibitory activity, important bioactivities in neurodegeneration. Antirrhinum lopesianum is a rare endemism from the Iberian Peninsula, occurring at the northeastern border between Portugal and Spain. It is classified as Endangered, due to its highly fragmented geographical occupation, facing a high risk of extinction in the Portuguese territory, within 20 years. Here, we describe for the first time the chemical characterization of extracts of the species concerning total phenol content, flavonoid content and antioxidant properties. The profile of high performance liquid chromatography with diode array detector (HPLC-DAD) of the polyphenol-enriched fraction of plant extracts was also performed, showing the great potential of the species as a source of bioactive phytochemical compounds. A. lopesianum’s potential for neuroprotection was revealed by a significant acetylcholinesterase inhibitory activity and also by a neuroprotective effect on a human cell model of neurodegeneration. Moreover, this is the first report describing a successful procedure for the in vitro propagation of this endangered species. The comparison of phenolic content and the HPLC-DAD profile of wild and in vitro propagated plants revealed that in vitro plants maintain the ability to produce secondary metabolites, but the profiles are differentially affected by the growth regulators. The results presented here greatly contribute to the value for this species regarding its potential as a source of phytochemicals with prospective neuroprotective health benefits. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-12-01 2013-12-01T00:00:00Z 2019-07-29T22:42:07Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.3390/antiox2040273 |
url |
https://doi.org/10.3390/antiox2040273 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
PURE: 14287528 http://www.scopus.com/inward/record.url?scp=84930935929&partnerID=8YFLogxK https://doi.org/10.3390/antiox2040273 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
20 application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799137977672138752 |