Wide variation in severe neonatal morbidity among very preterm infants in European regions

Detalhes bibliográficos
Autor(a) principal: Bonamy, AK
Data de Publicação: 2018
Outros Autores: Zeitlin, J, Piedvache, A, Maier, RF, van Heijst, A, Varendi H, Manktelow BN, Fenton A, Mazela J, Cuttini M, Norman M, Petrou S, Reempts PV, Barros H, Rodrigues, C, Rodrigues T
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10216/113056
Resumo: Objective To investigate the variation in severe neonatal morbidity among very preterm (VPT) infants across European regions and whether morbidity rates are higher in regions with low compared with high mortality rates. Design Area-based cohort study of all births before 32 weeks of gestational age. Setting 16 regions in 11 European countries in 2011/2012. Patients Survivors to discharge from neonatal care (n=6422). Main outcome measures Severe neonatal morbidity was defined as intraventricular haemorrhage grades III and IV, cystic periventricular leukomalacia, surgical necrotizing enterocolitis and retinopathy of prematurity grades ≥3. A secondary outcome included severe bronchopulmonary dysplasia (BPD), data available in 14 regions. Common definitions for neonatal morbidities were established before data abstraction from medical records. Regional severe neonatal morbidity rates were correlated with regional in-hospital mortality rates for live births after adjustment on maternal and neonatal characteristics. Results 10.6% of survivors had a severe neonatal morbidity without severe BPD (regional range 6.4%–23.5%) and 13.8% including severe BPD (regional range 10.0%–23.5%). Adjusted inhospital mortality was 13.7% (regional range 8.4%–18.8%). Differences between regions remained significant after consideration of maternal and neonatal characteristics (P<0.001) and severe neonatal morbidity rates were not correlated with mortality rates (P=0.50). Conclusion Severe neonatal morbidity rates for VPT survivors varied widely across European regions and were independent of mortality rates.
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spelling Wide variation in severe neonatal morbidity among very preterm infants in European regionsNeonatal morbidityVery preterm infantsObjective To investigate the variation in severe neonatal morbidity among very preterm (VPT) infants across European regions and whether morbidity rates are higher in regions with low compared with high mortality rates. Design Area-based cohort study of all births before 32 weeks of gestational age. Setting 16 regions in 11 European countries in 2011/2012. Patients Survivors to discharge from neonatal care (n=6422). Main outcome measures Severe neonatal morbidity was defined as intraventricular haemorrhage grades III and IV, cystic periventricular leukomalacia, surgical necrotizing enterocolitis and retinopathy of prematurity grades ≥3. A secondary outcome included severe bronchopulmonary dysplasia (BPD), data available in 14 regions. Common definitions for neonatal morbidities were established before data abstraction from medical records. Regional severe neonatal morbidity rates were correlated with regional in-hospital mortality rates for live births after adjustment on maternal and neonatal characteristics. Results 10.6% of survivors had a severe neonatal morbidity without severe BPD (regional range 6.4%–23.5%) and 13.8% including severe BPD (regional range 10.0%–23.5%). Adjusted inhospital mortality was 13.7% (regional range 8.4%–18.8%). Differences between regions remained significant after consideration of maternal and neonatal characteristics (P<0.001) and severe neonatal morbidity rates were not correlated with mortality rates (P=0.50). Conclusion Severe neonatal morbidity rates for VPT survivors varied widely across European regions and were independent of mortality rates.20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10216/113056eng1468-205210.1136/archdischild-2017-313697Bonamy, AKZeitlin, JPiedvache, AMaier, RFvan Heijst, AVarendi HManktelow BNFenton AMazela JCuttini MNorman MPetrou SReempts PVBarros HRodrigues, CRodrigues Tinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T13:33:10Zoai:repositorio-aberto.up.pt:10216/113056Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:42:29.877452Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Wide variation in severe neonatal morbidity among very preterm infants in European regions
title Wide variation in severe neonatal morbidity among very preterm infants in European regions
spellingShingle Wide variation in severe neonatal morbidity among very preterm infants in European regions
Bonamy, AK
Neonatal morbidity
Very preterm infants
title_short Wide variation in severe neonatal morbidity among very preterm infants in European regions
title_full Wide variation in severe neonatal morbidity among very preterm infants in European regions
title_fullStr Wide variation in severe neonatal morbidity among very preterm infants in European regions
title_full_unstemmed Wide variation in severe neonatal morbidity among very preterm infants in European regions
title_sort Wide variation in severe neonatal morbidity among very preterm infants in European regions
author Bonamy, AK
author_facet Bonamy, AK
Zeitlin, J
Piedvache, A
Maier, RF
van Heijst, A
Varendi H
Manktelow BN
Fenton A
Mazela J
Cuttini M
Norman M
Petrou S
Reempts PV
Barros H
Rodrigues, C
Rodrigues T
author_role author
author2 Zeitlin, J
Piedvache, A
Maier, RF
van Heijst, A
Varendi H
Manktelow BN
Fenton A
Mazela J
Cuttini M
Norman M
Petrou S
Reempts PV
Barros H
Rodrigues, C
Rodrigues T
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bonamy, AK
Zeitlin, J
Piedvache, A
Maier, RF
van Heijst, A
Varendi H
Manktelow BN
Fenton A
Mazela J
Cuttini M
Norman M
Petrou S
Reempts PV
Barros H
Rodrigues, C
Rodrigues T
dc.subject.por.fl_str_mv Neonatal morbidity
Very preterm infants
topic Neonatal morbidity
Very preterm infants
description Objective To investigate the variation in severe neonatal morbidity among very preterm (VPT) infants across European regions and whether morbidity rates are higher in regions with low compared with high mortality rates. Design Area-based cohort study of all births before 32 weeks of gestational age. Setting 16 regions in 11 European countries in 2011/2012. Patients Survivors to discharge from neonatal care (n=6422). Main outcome measures Severe neonatal morbidity was defined as intraventricular haemorrhage grades III and IV, cystic periventricular leukomalacia, surgical necrotizing enterocolitis and retinopathy of prematurity grades ≥3. A secondary outcome included severe bronchopulmonary dysplasia (BPD), data available in 14 regions. Common definitions for neonatal morbidities were established before data abstraction from medical records. Regional severe neonatal morbidity rates were correlated with regional in-hospital mortality rates for live births after adjustment on maternal and neonatal characteristics. Results 10.6% of survivors had a severe neonatal morbidity without severe BPD (regional range 6.4%–23.5%) and 13.8% including severe BPD (regional range 10.0%–23.5%). Adjusted inhospital mortality was 13.7% (regional range 8.4%–18.8%). Differences between regions remained significant after consideration of maternal and neonatal characteristics (P<0.001) and severe neonatal morbidity rates were not correlated with mortality rates (P=0.50). Conclusion Severe neonatal morbidity rates for VPT survivors varied widely across European regions and were independent of mortality rates.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10216/113056
url http://hdl.handle.net/10216/113056
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1468-2052
10.1136/archdischild-2017-313697
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dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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