SURGICAL TREATMENT OF CAROTID BODY TUMORS — A SINGLE CENTER EXPERIENCE AND LITERATURE REVIEW

Detalhes bibliográficos
Autor(a) principal: Catarino, Joana
Data de Publicação: 2019
Outros Autores: Alves, Gonçalo, Camacho, Nelson, Correia, Ricardo, Bento, Rita, Pais, Fábio, Garcia, Rita, Ferreira, Maria Emília
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.48750/acv.250
Resumo: Introduction: Carotid body tumors (CBT) are rare (1–2/100.000) slow-growing, hipervascular neuroendocrine tumors, originate from the neural crest. Their exact cause is unknown. Most are sporadic, but a subset (25%) are associated with hereditary paraganglioma syndrome. Complete surgical removal is the treatment of choice for all CBTs. Methods: This is a retrospective study of patients with CBT, who were treated at our institution between 2012 and 2018 and a literature review. Results: Over the last 6 years, 13 patients were treated for CBTs in our center (7 female, 6 male), who were aged 46 years (range 14–72 years). Three (23%) of the tumors were Shamblin I, eight (61,5%) Shamblin II and two (15,5%) Shamblin III. The median tumor diameter was 3,6 cm (range from 2,5 to 6,6cm). We performed preoperative embolization with micro coils in 5 patients (39%), 2 days before surgery.Two patients (40%) presented with Shamblin's III tumors (one with cranial extension) and 3 (60%) had tumor >5cm, Shamblin II. There were no postembolization strokes, TIAs or access site hematomas. All 13 CBTs tumors (including large tumors, extended cranially and Shamblin's III) were treated with resection alone (100%), without need for arterial resection or reconstruction. Average blood loss was 130 mL (range from 100 to 180 mL). In this study the overall rate of complications was 7% (1 patient) who had permanent hoarseness due to vagus nerve resection (vagus sacrificed due to tumor involvement), there were no cases of stroke, TIA or hematoma . There were no mortalities in the perioperative period or during follow-up. Conclusion: CBTs are rare and surgical excision can be very demanding and laborious. From our experience, pre-operative embolization is safe and may be of value in large and Shamblin III tumors.
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spelling SURGICAL TREATMENT OF CAROTID BODY TUMORS — A SINGLE CENTER EXPERIENCE AND LITERATURE REVIEWTRATAMENTO CIRÚRGICO DE TUMORES DO CORPO CAROTÍDEO — EXPERIÊNCIA DE UM CENTRO E REVISÃO DE LITERATURACarotid body tumorsurgical treatmentSurgical treatmentPre-operative embolizationTumores corpo carotídeoTratamento cirúrgicoEmbolização pré-operatóriaIntroduction: Carotid body tumors (CBT) are rare (1–2/100.000) slow-growing, hipervascular neuroendocrine tumors, originate from the neural crest. Their exact cause is unknown. Most are sporadic, but a subset (25%) are associated with hereditary paraganglioma syndrome. Complete surgical removal is the treatment of choice for all CBTs. Methods: This is a retrospective study of patients with CBT, who were treated at our institution between 2012 and 2018 and a literature review. Results: Over the last 6 years, 13 patients were treated for CBTs in our center (7 female, 6 male), who were aged 46 years (range 14–72 years). Three (23%) of the tumors were Shamblin I, eight (61,5%) Shamblin II and two (15,5%) Shamblin III. The median tumor diameter was 3,6 cm (range from 2,5 to 6,6cm). We performed preoperative embolization with micro coils in 5 patients (39%), 2 days before surgery.Two patients (40%) presented with Shamblin's III tumors (one with cranial extension) and 3 (60%) had tumor >5cm, Shamblin II. There were no postembolization strokes, TIAs or access site hematomas. All 13 CBTs tumors (including large tumors, extended cranially and Shamblin's III) were treated with resection alone (100%), without need for arterial resection or reconstruction. Average blood loss was 130 mL (range from 100 to 180 mL). In this study the overall rate of complications was 7% (1 patient) who had permanent hoarseness due to vagus nerve resection (vagus sacrificed due to tumor involvement), there were no cases of stroke, TIA or hematoma . There were no mortalities in the perioperative period or during follow-up. Conclusion: CBTs are rare and surgical excision can be very demanding and laborious. From our experience, pre-operative embolization is safe and may be of value in large and Shamblin III tumors.Introdução: Os tumores do corpo carotídeo (TCC) são tumores raros (1–2/100.000), de crescimento lento, neuroendócrinos e hipervasculares. A sua causa exata é desconhecida e a maioria são esporádicos. O tratamento cirúrgico através da excisão completa do tumor é o goldstandard. Métodos: Estudo retrospectivo dos doentes com TCC submetidos a tratamento cirúrgico na nossa instituição, entre 2012 e 2018 e revisão da literatura. Resultados: No período entre 2012 e 2018 foram tratados 13 doentes com TCC, 7 mulheres (54%) e 6 homens (46%), com idade média de 46 anos (min. 14 — máx. 72 anos). Três (23%) foram classificados como Shamblin I, oito (61,5%) Shamblin II e dois (15,5%) Shamblin III. O tamanho médio dos tumores foi de 3,6cm (min. 2,5cm — máx. 6,6cm). Realizámos embolização pré-operatória em 5 doentes (39%), dois dias antes da cirurgia. Dois dos doentes (40%) apresentavam tumores Shamblin III (um deles com extensa extensão cranial) e três doentes (60%) tumores >5cm Shamblin II. Não se registaram AIT, AVC ou complicações do acesso, associadas ao procedimento. Todos os 13 TCC foram tratados cirurgicamente com ressecção simples (100%), sem necessidade de reconstrução arterial. As perdas hemáticas médias foram de 130ml (min. 100 – máx. 180ml). Neste estudo a taxa de complicações total foi de 7%, um doente com rouquido permanente por lesão no nervo vago (nervo sacrificado por envolvimento tumoral), não houve registo de AIT, AVC ou hematomas. Não houve mortalidade peri-operatória ou durante o follow-up. Conclusão: Os TCC são raros e o seu tratamento cirúrgico pode ser extremamente exigente e trabalhoso. Na nossa expe- riência a embolização pré operatória é segura e pode ser uma mais valia principalmente em tumores de grandes dimensões e/ou classe Shamblin III.Sociedade Portuguesa de Angiologia e Cirurgia Vascular2019-12-27T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.48750/acv.250oai:ojs.acvjournal.com:article/250Angiologia e Cirurgia Vascular; Vol. 15 No. 3 (2019): September; 181-187Angiologia e Cirurgia Vascular; Vol. 15 N.º 3 (2019): Setembro; 181-1872183-00961646-706Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttp://acvjournal.com/index.php/acv/article/view/250https://doi.org/10.48750/acv.250http://acvjournal.com/index.php/acv/article/view/250/148Copyright (c) 2019 Angiologia e Cirurgia Vascularinfo:eu-repo/semantics/openAccessCatarino, JoanaAlves, GonçaloCamacho, NelsonCorreia, RicardoBento, RitaPais, FábioGarcia, RitaFerreira, Maria Emília2022-05-23T15:10:06Zoai:ojs.acvjournal.com:article/250Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T14:57:37.665752Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv SURGICAL TREATMENT OF CAROTID BODY TUMORS — A SINGLE CENTER EXPERIENCE AND LITERATURE REVIEW
TRATAMENTO CIRÚRGICO DE TUMORES DO CORPO CAROTÍDEO — EXPERIÊNCIA DE UM CENTRO E REVISÃO DE LITERATURA
title SURGICAL TREATMENT OF CAROTID BODY TUMORS — A SINGLE CENTER EXPERIENCE AND LITERATURE REVIEW
spellingShingle SURGICAL TREATMENT OF CAROTID BODY TUMORS — A SINGLE CENTER EXPERIENCE AND LITERATURE REVIEW
Catarino, Joana
Carotid body tumors
urgical treatment
Surgical treatment
Pre-operative embolization
Tumores corpo carotídeo
Tratamento cirúrgico
Embolização pré-operatória
title_short SURGICAL TREATMENT OF CAROTID BODY TUMORS — A SINGLE CENTER EXPERIENCE AND LITERATURE REVIEW
title_full SURGICAL TREATMENT OF CAROTID BODY TUMORS — A SINGLE CENTER EXPERIENCE AND LITERATURE REVIEW
title_fullStr SURGICAL TREATMENT OF CAROTID BODY TUMORS — A SINGLE CENTER EXPERIENCE AND LITERATURE REVIEW
title_full_unstemmed SURGICAL TREATMENT OF CAROTID BODY TUMORS — A SINGLE CENTER EXPERIENCE AND LITERATURE REVIEW
title_sort SURGICAL TREATMENT OF CAROTID BODY TUMORS — A SINGLE CENTER EXPERIENCE AND LITERATURE REVIEW
author Catarino, Joana
author_facet Catarino, Joana
Alves, Gonçalo
Camacho, Nelson
Correia, Ricardo
Bento, Rita
Pais, Fábio
Garcia, Rita
Ferreira, Maria Emília
author_role author
author2 Alves, Gonçalo
Camacho, Nelson
Correia, Ricardo
Bento, Rita
Pais, Fábio
Garcia, Rita
Ferreira, Maria Emília
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Catarino, Joana
Alves, Gonçalo
Camacho, Nelson
Correia, Ricardo
Bento, Rita
Pais, Fábio
Garcia, Rita
Ferreira, Maria Emília
dc.subject.por.fl_str_mv Carotid body tumors
urgical treatment
Surgical treatment
Pre-operative embolization
Tumores corpo carotídeo
Tratamento cirúrgico
Embolização pré-operatória
topic Carotid body tumors
urgical treatment
Surgical treatment
Pre-operative embolization
Tumores corpo carotídeo
Tratamento cirúrgico
Embolização pré-operatória
description Introduction: Carotid body tumors (CBT) are rare (1–2/100.000) slow-growing, hipervascular neuroendocrine tumors, originate from the neural crest. Their exact cause is unknown. Most are sporadic, but a subset (25%) are associated with hereditary paraganglioma syndrome. Complete surgical removal is the treatment of choice for all CBTs. Methods: This is a retrospective study of patients with CBT, who were treated at our institution between 2012 and 2018 and a literature review. Results: Over the last 6 years, 13 patients were treated for CBTs in our center (7 female, 6 male), who were aged 46 years (range 14–72 years). Three (23%) of the tumors were Shamblin I, eight (61,5%) Shamblin II and two (15,5%) Shamblin III. The median tumor diameter was 3,6 cm (range from 2,5 to 6,6cm). We performed preoperative embolization with micro coils in 5 patients (39%), 2 days before surgery.Two patients (40%) presented with Shamblin's III tumors (one with cranial extension) and 3 (60%) had tumor >5cm, Shamblin II. There were no postembolization strokes, TIAs or access site hematomas. All 13 CBTs tumors (including large tumors, extended cranially and Shamblin's III) were treated with resection alone (100%), without need for arterial resection or reconstruction. Average blood loss was 130 mL (range from 100 to 180 mL). In this study the overall rate of complications was 7% (1 patient) who had permanent hoarseness due to vagus nerve resection (vagus sacrificed due to tumor involvement), there were no cases of stroke, TIA or hematoma . There were no mortalities in the perioperative period or during follow-up. Conclusion: CBTs are rare and surgical excision can be very demanding and laborious. From our experience, pre-operative embolization is safe and may be of value in large and Shamblin III tumors.
publishDate 2019
dc.date.none.fl_str_mv 2019-12-27T00:00:00Z
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dc.relation.none.fl_str_mv http://acvjournal.com/index.php/acv/article/view/250
https://doi.org/10.48750/acv.250
http://acvjournal.com/index.php/acv/article/view/250/148
dc.rights.driver.fl_str_mv Copyright (c) 2019 Angiologia e Cirurgia Vascular
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2019 Angiologia e Cirurgia Vascular
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Angiologia e Cirurgia Vascular
publisher.none.fl_str_mv Sociedade Portuguesa de Angiologia e Cirurgia Vascular
dc.source.none.fl_str_mv Angiologia e Cirurgia Vascular; Vol. 15 No. 3 (2019): September; 181-187
Angiologia e Cirurgia Vascular; Vol. 15 N.º 3 (2019): Setembro; 181-187
2183-0096
1646-706X
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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