SURGICAL TREATMENT OF CAROTID BODY TUMORS — A SINGLE CENTER EXPERIENCE AND LITERATURE REVIEW
Autor(a) principal: | |
---|---|
Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.48750/acv.250 |
Resumo: | Introduction: Carotid body tumors (CBT) are rare (1–2/100.000) slow-growing, hipervascular neuroendocrine tumors, originate from the neural crest. Their exact cause is unknown. Most are sporadic, but a subset (25%) are associated with hereditary paraganglioma syndrome. Complete surgical removal is the treatment of choice for all CBTs. Methods: This is a retrospective study of patients with CBT, who were treated at our institution between 2012 and 2018 and a literature review. Results: Over the last 6 years, 13 patients were treated for CBTs in our center (7 female, 6 male), who were aged 46 years (range 14–72 years). Three (23%) of the tumors were Shamblin I, eight (61,5%) Shamblin II and two (15,5%) Shamblin III. The median tumor diameter was 3,6 cm (range from 2,5 to 6,6cm). We performed preoperative embolization with micro coils in 5 patients (39%), 2 days before surgery.Two patients (40%) presented with Shamblin's III tumors (one with cranial extension) and 3 (60%) had tumor >5cm, Shamblin II. There were no postembolization strokes, TIAs or access site hematomas. All 13 CBTs tumors (including large tumors, extended cranially and Shamblin's III) were treated with resection alone (100%), without need for arterial resection or reconstruction. Average blood loss was 130 mL (range from 100 to 180 mL). In this study the overall rate of complications was 7% (1 patient) who had permanent hoarseness due to vagus nerve resection (vagus sacrificed due to tumor involvement), there were no cases of stroke, TIA or hematoma . There were no mortalities in the perioperative period or during follow-up. Conclusion: CBTs are rare and surgical excision can be very demanding and laborious. From our experience, pre-operative embolization is safe and may be of value in large and Shamblin III tumors. |
id |
RCAP_cdec9596f4a0b48708b8cd33174747d8 |
---|---|
oai_identifier_str |
oai:ojs.acvjournal.com:article/250 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
SURGICAL TREATMENT OF CAROTID BODY TUMORS — A SINGLE CENTER EXPERIENCE AND LITERATURE REVIEWTRATAMENTO CIRÚRGICO DE TUMORES DO CORPO CAROTÍDEO — EXPERIÊNCIA DE UM CENTRO E REVISÃO DE LITERATURACarotid body tumorsurgical treatmentSurgical treatmentPre-operative embolizationTumores corpo carotídeoTratamento cirúrgicoEmbolização pré-operatóriaIntroduction: Carotid body tumors (CBT) are rare (1–2/100.000) slow-growing, hipervascular neuroendocrine tumors, originate from the neural crest. Their exact cause is unknown. Most are sporadic, but a subset (25%) are associated with hereditary paraganglioma syndrome. Complete surgical removal is the treatment of choice for all CBTs. Methods: This is a retrospective study of patients with CBT, who were treated at our institution between 2012 and 2018 and a literature review. Results: Over the last 6 years, 13 patients were treated for CBTs in our center (7 female, 6 male), who were aged 46 years (range 14–72 years). Three (23%) of the tumors were Shamblin I, eight (61,5%) Shamblin II and two (15,5%) Shamblin III. The median tumor diameter was 3,6 cm (range from 2,5 to 6,6cm). We performed preoperative embolization with micro coils in 5 patients (39%), 2 days before surgery.Two patients (40%) presented with Shamblin's III tumors (one with cranial extension) and 3 (60%) had tumor >5cm, Shamblin II. There were no postembolization strokes, TIAs or access site hematomas. All 13 CBTs tumors (including large tumors, extended cranially and Shamblin's III) were treated with resection alone (100%), without need for arterial resection or reconstruction. Average blood loss was 130 mL (range from 100 to 180 mL). In this study the overall rate of complications was 7% (1 patient) who had permanent hoarseness due to vagus nerve resection (vagus sacrificed due to tumor involvement), there were no cases of stroke, TIA or hematoma . There were no mortalities in the perioperative period or during follow-up. Conclusion: CBTs are rare and surgical excision can be very demanding and laborious. From our experience, pre-operative embolization is safe and may be of value in large and Shamblin III tumors.Introdução: Os tumores do corpo carotídeo (TCC) são tumores raros (1–2/100.000), de crescimento lento, neuroendócrinos e hipervasculares. A sua causa exata é desconhecida e a maioria são esporádicos. O tratamento cirúrgico através da excisão completa do tumor é o goldstandard. Métodos: Estudo retrospectivo dos doentes com TCC submetidos a tratamento cirúrgico na nossa instituição, entre 2012 e 2018 e revisão da literatura. Resultados: No período entre 2012 e 2018 foram tratados 13 doentes com TCC, 7 mulheres (54%) e 6 homens (46%), com idade média de 46 anos (min. 14 — máx. 72 anos). Três (23%) foram classificados como Shamblin I, oito (61,5%) Shamblin II e dois (15,5%) Shamblin III. O tamanho médio dos tumores foi de 3,6cm (min. 2,5cm — máx. 6,6cm). Realizámos embolização pré-operatória em 5 doentes (39%), dois dias antes da cirurgia. Dois dos doentes (40%) apresentavam tumores Shamblin III (um deles com extensa extensão cranial) e três doentes (60%) tumores >5cm Shamblin II. Não se registaram AIT, AVC ou complicações do acesso, associadas ao procedimento. Todos os 13 TCC foram tratados cirurgicamente com ressecção simples (100%), sem necessidade de reconstrução arterial. As perdas hemáticas médias foram de 130ml (min. 100 – máx. 180ml). Neste estudo a taxa de complicações total foi de 7%, um doente com rouquido permanente por lesão no nervo vago (nervo sacrificado por envolvimento tumoral), não houve registo de AIT, AVC ou hematomas. Não houve mortalidade peri-operatória ou durante o follow-up. Conclusão: Os TCC são raros e o seu tratamento cirúrgico pode ser extremamente exigente e trabalhoso. Na nossa expe- riência a embolização pré operatória é segura e pode ser uma mais valia principalmente em tumores de grandes dimensões e/ou classe Shamblin III.Sociedade Portuguesa de Angiologia e Cirurgia Vascular2019-12-27T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.48750/acv.250oai:ojs.acvjournal.com:article/250Angiologia e Cirurgia Vascular; Vol. 15 No. 3 (2019): September; 181-187Angiologia e Cirurgia Vascular; Vol. 15 N.º 3 (2019): Setembro; 181-1872183-00961646-706Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttp://acvjournal.com/index.php/acv/article/view/250https://doi.org/10.48750/acv.250http://acvjournal.com/index.php/acv/article/view/250/148Copyright (c) 2019 Angiologia e Cirurgia Vascularinfo:eu-repo/semantics/openAccessCatarino, JoanaAlves, GonçaloCamacho, NelsonCorreia, RicardoBento, RitaPais, FábioGarcia, RitaFerreira, Maria Emília2022-05-23T15:10:06Zoai:ojs.acvjournal.com:article/250Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T14:57:37.665752Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
SURGICAL TREATMENT OF CAROTID BODY TUMORS — A SINGLE CENTER EXPERIENCE AND LITERATURE REVIEW TRATAMENTO CIRÚRGICO DE TUMORES DO CORPO CAROTÍDEO — EXPERIÊNCIA DE UM CENTRO E REVISÃO DE LITERATURA |
title |
SURGICAL TREATMENT OF CAROTID BODY TUMORS — A SINGLE CENTER EXPERIENCE AND LITERATURE REVIEW |
spellingShingle |
SURGICAL TREATMENT OF CAROTID BODY TUMORS — A SINGLE CENTER EXPERIENCE AND LITERATURE REVIEW Catarino, Joana Carotid body tumors urgical treatment Surgical treatment Pre-operative embolization Tumores corpo carotídeo Tratamento cirúrgico Embolização pré-operatória |
title_short |
SURGICAL TREATMENT OF CAROTID BODY TUMORS — A SINGLE CENTER EXPERIENCE AND LITERATURE REVIEW |
title_full |
SURGICAL TREATMENT OF CAROTID BODY TUMORS — A SINGLE CENTER EXPERIENCE AND LITERATURE REVIEW |
title_fullStr |
SURGICAL TREATMENT OF CAROTID BODY TUMORS — A SINGLE CENTER EXPERIENCE AND LITERATURE REVIEW |
title_full_unstemmed |
SURGICAL TREATMENT OF CAROTID BODY TUMORS — A SINGLE CENTER EXPERIENCE AND LITERATURE REVIEW |
title_sort |
SURGICAL TREATMENT OF CAROTID BODY TUMORS — A SINGLE CENTER EXPERIENCE AND LITERATURE REVIEW |
author |
Catarino, Joana |
author_facet |
Catarino, Joana Alves, Gonçalo Camacho, Nelson Correia, Ricardo Bento, Rita Pais, Fábio Garcia, Rita Ferreira, Maria Emília |
author_role |
author |
author2 |
Alves, Gonçalo Camacho, Nelson Correia, Ricardo Bento, Rita Pais, Fábio Garcia, Rita Ferreira, Maria Emília |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Catarino, Joana Alves, Gonçalo Camacho, Nelson Correia, Ricardo Bento, Rita Pais, Fábio Garcia, Rita Ferreira, Maria Emília |
dc.subject.por.fl_str_mv |
Carotid body tumors urgical treatment Surgical treatment Pre-operative embolization Tumores corpo carotídeo Tratamento cirúrgico Embolização pré-operatória |
topic |
Carotid body tumors urgical treatment Surgical treatment Pre-operative embolization Tumores corpo carotídeo Tratamento cirúrgico Embolização pré-operatória |
description |
Introduction: Carotid body tumors (CBT) are rare (1–2/100.000) slow-growing, hipervascular neuroendocrine tumors, originate from the neural crest. Their exact cause is unknown. Most are sporadic, but a subset (25%) are associated with hereditary paraganglioma syndrome. Complete surgical removal is the treatment of choice for all CBTs. Methods: This is a retrospective study of patients with CBT, who were treated at our institution between 2012 and 2018 and a literature review. Results: Over the last 6 years, 13 patients were treated for CBTs in our center (7 female, 6 male), who were aged 46 years (range 14–72 years). Three (23%) of the tumors were Shamblin I, eight (61,5%) Shamblin II and two (15,5%) Shamblin III. The median tumor diameter was 3,6 cm (range from 2,5 to 6,6cm). We performed preoperative embolization with micro coils in 5 patients (39%), 2 days before surgery.Two patients (40%) presented with Shamblin's III tumors (one with cranial extension) and 3 (60%) had tumor >5cm, Shamblin II. There were no postembolization strokes, TIAs or access site hematomas. All 13 CBTs tumors (including large tumors, extended cranially and Shamblin's III) were treated with resection alone (100%), without need for arterial resection or reconstruction. Average blood loss was 130 mL (range from 100 to 180 mL). In this study the overall rate of complications was 7% (1 patient) who had permanent hoarseness due to vagus nerve resection (vagus sacrificed due to tumor involvement), there were no cases of stroke, TIA or hematoma . There were no mortalities in the perioperative period or during follow-up. Conclusion: CBTs are rare and surgical excision can be very demanding and laborious. From our experience, pre-operative embolization is safe and may be of value in large and Shamblin III tumors. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-12-27T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.48750/acv.250 oai:ojs.acvjournal.com:article/250 |
url |
https://doi.org/10.48750/acv.250 |
identifier_str_mv |
oai:ojs.acvjournal.com:article/250 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
http://acvjournal.com/index.php/acv/article/view/250 https://doi.org/10.48750/acv.250 http://acvjournal.com/index.php/acv/article/view/250/148 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2019 Angiologia e Cirurgia Vascular info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2019 Angiologia e Cirurgia Vascular |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Angiologia e Cirurgia Vascular |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Angiologia e Cirurgia Vascular |
dc.source.none.fl_str_mv |
Angiologia e Cirurgia Vascular; Vol. 15 No. 3 (2019): September; 181-187 Angiologia e Cirurgia Vascular; Vol. 15 N.º 3 (2019): Setembro; 181-187 2183-0096 1646-706X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799129849701335040 |