Nanoparticles for recognition and delivery in metastatic colorectal cancer cells

Detalhes bibliográficos
Autor(a) principal: Roda, Ana Sofia Martins
Data de Publicação: 2016
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/63808
Resumo: "Colorectal cancer is a global health concern. The high incidence of colorectal metastasis, mainly in the liver, triggers an increase of the mortality rate and greatly reduces the effective cure chances. For this reason, the investigation in the area is now focused on efficient detection and elimination of metastasis. Nanotechnology has become a fundamental research field since it provides promising perspectives regarding specific, oriented and sustained delivery of loaded nanoparticles for nanoteragnostic approaches. The current project aims to develop a nanocarrier, strategically constructed for specific administration, recognition and therapy of colorectal liver metastasis. Concerning this goal, two different approaches were concurrently developed: a green-therapeutic technology and a novel nanoparticulate system, by nanoprecipitation and inverse microemulsion, respectively. (…)"
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spelling Nanoparticles for recognition and delivery in metastatic colorectal cancer cellsmetastatic colorectal cancerpolymeric nanoparticlesdrug deliverymPEG-co-PCLchitosancollagenase"Colorectal cancer is a global health concern. The high incidence of colorectal metastasis, mainly in the liver, triggers an increase of the mortality rate and greatly reduces the effective cure chances. For this reason, the investigation in the area is now focused on efficient detection and elimination of metastasis. Nanotechnology has become a fundamental research field since it provides promising perspectives regarding specific, oriented and sustained delivery of loaded nanoparticles for nanoteragnostic approaches. The current project aims to develop a nanocarrier, strategically constructed for specific administration, recognition and therapy of colorectal liver metastasis. Concerning this goal, two different approaches were concurrently developed: a green-therapeutic technology and a novel nanoparticulate system, by nanoprecipitation and inverse microemulsion, respectively. (…)"Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica António XavierRUNRoda, Ana Sofia Martins2019-03-19T16:24:48Z2016-102016-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10362/63808enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:30:16Zoai:run.unl.pt:10362/63808Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:33:59.471675Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Nanoparticles for recognition and delivery in metastatic colorectal cancer cells
title Nanoparticles for recognition and delivery in metastatic colorectal cancer cells
spellingShingle Nanoparticles for recognition and delivery in metastatic colorectal cancer cells
Roda, Ana Sofia Martins
metastatic colorectal cancer
polymeric nanoparticles
drug delivery
mPEG-co-PCL
chitosan
collagenase
title_short Nanoparticles for recognition and delivery in metastatic colorectal cancer cells
title_full Nanoparticles for recognition and delivery in metastatic colorectal cancer cells
title_fullStr Nanoparticles for recognition and delivery in metastatic colorectal cancer cells
title_full_unstemmed Nanoparticles for recognition and delivery in metastatic colorectal cancer cells
title_sort Nanoparticles for recognition and delivery in metastatic colorectal cancer cells
author Roda, Ana Sofia Martins
author_facet Roda, Ana Sofia Martins
author_role author
dc.contributor.none.fl_str_mv RUN
dc.contributor.author.fl_str_mv Roda, Ana Sofia Martins
dc.subject.por.fl_str_mv metastatic colorectal cancer
polymeric nanoparticles
drug delivery
mPEG-co-PCL
chitosan
collagenase
topic metastatic colorectal cancer
polymeric nanoparticles
drug delivery
mPEG-co-PCL
chitosan
collagenase
description "Colorectal cancer is a global health concern. The high incidence of colorectal metastasis, mainly in the liver, triggers an increase of the mortality rate and greatly reduces the effective cure chances. For this reason, the investigation in the area is now focused on efficient detection and elimination of metastasis. Nanotechnology has become a fundamental research field since it provides promising perspectives regarding specific, oriented and sustained delivery of loaded nanoparticles for nanoteragnostic approaches. The current project aims to develop a nanocarrier, strategically constructed for specific administration, recognition and therapy of colorectal liver metastasis. Concerning this goal, two different approaches were concurrently developed: a green-therapeutic technology and a novel nanoparticulate system, by nanoprecipitation and inverse microemulsion, respectively. (…)"
publishDate 2016
dc.date.none.fl_str_mv 2016-10
2016-10-01T00:00:00Z
2019-03-19T16:24:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/63808
url http://hdl.handle.net/10362/63808
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica António Xavier
publisher.none.fl_str_mv Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica António Xavier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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