Modulation of Leptin and Leptin Receptor Expression in Mice Acutely Infected with Neospora caninum
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/10216/128289 |
Resumo: | Neospora caninumis an apicomplexan parasite that in cattle assumes particular importance, as it is responsible for abortions reported worldwide. Leptin is an adipokine mainly secreted by adipocytes, which beside its role in maintaining metabolic homeostasis also has important effects in both innate and adaptive immunity. In previous work, we showed that mice chronically infected withN. caninumhad elevated serum leptin levels. Here, we sought to assess whether acute infection withN. caninuminfection influenced the production of this adipokine as well as leptin receptor mRNA levels. Our results show that acute infection withN. caninumled to decreased leptin serum levels and mRNA expression in adipose tissue. A decrease in leptin receptor transcript variant 1 mRNA (long isoform) and leptin receptor transcript variant 3 mRNA (one of the short isoforms) expression was also observed. An increase in the number of cells staining positive for leptin in the liver of infected mice was observed, although this increase was less marked in Interleukin (IL)-12/IL-23 p40-deficient mice. Overall, our results show thatN. caninuminfection also influences leptin production during acute infection. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
spelling |
Modulation of Leptin and Leptin Receptor Expression in Mice Acutely Infected with Neospora caninumNeospora caninumis an apicomplexan parasite that in cattle assumes particular importance, as it is responsible for abortions reported worldwide. Leptin is an adipokine mainly secreted by adipocytes, which beside its role in maintaining metabolic homeostasis also has important effects in both innate and adaptive immunity. In previous work, we showed that mice chronically infected withN. caninumhad elevated serum leptin levels. Here, we sought to assess whether acute infection withN. caninuminfection influenced the production of this adipokine as well as leptin receptor mRNA levels. Our results show that acute infection withN. caninumled to decreased leptin serum levels and mRNA expression in adipose tissue. A decrease in leptin receptor transcript variant 1 mRNA (long isoform) and leptin receptor transcript variant 3 mRNA (one of the short isoforms) expression was also observed. An increase in the number of cells staining positive for leptin in the liver of infected mice was observed, although this increase was less marked in Interleukin (IL)-12/IL-23 p40-deficient mice. Overall, our results show thatN. caninuminfection also influences leptin production during acute infection.20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/128289eng10.3390/pathogens9070587Teixeira, LCorreia, AOliveira, BMPinto, AFerreira, PGManuel Vilanovainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-09-27T07:36:32Zoai:repositorio-aberto.up.pt:10216/128289Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-09-27T07:36:32Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Modulation of Leptin and Leptin Receptor Expression in Mice Acutely Infected with Neospora caninum |
title |
Modulation of Leptin and Leptin Receptor Expression in Mice Acutely Infected with Neospora caninum |
spellingShingle |
Modulation of Leptin and Leptin Receptor Expression in Mice Acutely Infected with Neospora caninum Teixeira, L |
title_short |
Modulation of Leptin and Leptin Receptor Expression in Mice Acutely Infected with Neospora caninum |
title_full |
Modulation of Leptin and Leptin Receptor Expression in Mice Acutely Infected with Neospora caninum |
title_fullStr |
Modulation of Leptin and Leptin Receptor Expression in Mice Acutely Infected with Neospora caninum |
title_full_unstemmed |
Modulation of Leptin and Leptin Receptor Expression in Mice Acutely Infected with Neospora caninum |
title_sort |
Modulation of Leptin and Leptin Receptor Expression in Mice Acutely Infected with Neospora caninum |
author |
Teixeira, L |
author_facet |
Teixeira, L Correia, A Oliveira, BM Pinto, A Ferreira, PG Manuel Vilanova |
author_role |
author |
author2 |
Correia, A Oliveira, BM Pinto, A Ferreira, PG Manuel Vilanova |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Teixeira, L Correia, A Oliveira, BM Pinto, A Ferreira, PG Manuel Vilanova |
description |
Neospora caninumis an apicomplexan parasite that in cattle assumes particular importance, as it is responsible for abortions reported worldwide. Leptin is an adipokine mainly secreted by adipocytes, which beside its role in maintaining metabolic homeostasis also has important effects in both innate and adaptive immunity. In previous work, we showed that mice chronically infected withN. caninumhad elevated serum leptin levels. Here, we sought to assess whether acute infection withN. caninuminfection influenced the production of this adipokine as well as leptin receptor mRNA levels. Our results show that acute infection withN. caninumled to decreased leptin serum levels and mRNA expression in adipose tissue. A decrease in leptin receptor transcript variant 1 mRNA (long isoform) and leptin receptor transcript variant 3 mRNA (one of the short isoforms) expression was also observed. An increase in the number of cells staining positive for leptin in the liver of infected mice was observed, although this increase was less marked in Interleukin (IL)-12/IL-23 p40-deficient mice. Overall, our results show thatN. caninuminfection also influences leptin production during acute infection. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020 2020-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/10216/128289 |
url |
https://hdl.handle.net/10216/128289 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.3390/pathogens9070587 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
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1817547623056277504 |