Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer’s disease : two triggers, one disease
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/46491 |
Resumo: | © Neural Regeneration Research. This is an open access journal, and articles are distributed under the terms of the Creative Commons AttributionNonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
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Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer’s disease : two triggers, one diseaseAggregationAlzheimerAmylinAmyloidDiabetesIslet amyloid polypeptide© Neural Regeneration Research. This is an open access journal, and articles are distributed under the terms of the Creative Commons AttributionNonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.Alzheimer’s disease (AD) is a neurodegenerative disorder that affects millions worldwide. Due to population ageing, the incidence of AD is increasing. AD patients develop cognitive decline and dementia, features for which is known, requiring permanent care. This poses a major socio-economic burden on healthcare systems as AD patients’ relatives and healthcare workers are forced to cope with rising numbers of affected people. Despite recent advances, AD pathological mechanisms are not fully understood. Nevertheless, it is clear that the amyloid beta (Aβ) peptide, which forms amyloid plaques in AD patients’ brains, plays a key role. Type 2 diabetes, the most common form of diabetes, affects hundreds of million people globally. Islet amyloid polypeptide (IAPP) is a hormone coproduced and secreted with insulin in pancreatic β-cells, with a key role in diabetes, as it helps regulate glucose levels and control adiposity and satiation. Similarly to Aβ, IAPP is very amyloidogenic, generating intracellular amyloid deposits that cause β-cell dysfunction and death. It is now clear that IAPP can also have a pathological role in AD, decreasing cognitive function. IAPP harms the blood-brain barrier, directly interacts and co-deposits with Aβ, promoting diabetes-associated dementia. IAPP can cause a metabolic dysfunction in the brain, leading to other diabetes-related forms of AD. Thus, here we discuss IAPP association with diabetes, Aβ and dementia, in the context of what we designate a “diabetes brain phenotype” AD hypothesis. Such approach helps to set a conceptual framework for future IAPP-based drugs against AD.This work was supported by iNOVA4Health – UID/Multi/04462/2019, a program financially supported by Fundação para a Ciência e Tecnologia/ Ministério da Educação e Ciência, through national funds and co-funded by FEDER under the PT2020 Partnership Agreement, Funding from INTERFACE Programme, through the Innovation, Technology and Circular Economy Fund (FITEC), FCT via PTDC/BIA-MOL/31104/2017 and UID/Multi/04462/2019-SubProj iNOVA4Health C44 (to RM), PD/BD/135504/2018 (to AFR), Sociedade Portuguesa de Diabetologia for the Nuno Castelo-Branco Prize – 2016 (to RM), and ICM acknowledges FCT-MCTES Program “Concurso de Estímulo ao Emprego Científico” (CEECIND/01670/2017)Wolters KluwerRepositório da Universidade de LisboaMartins, Ivo C.Menezes, ReginaFerreira, SofiaRaimundo, Ana F.2021-02-23T13:42:35Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/46491engNeural Regen Res. 2021 Jun;16(6):1127-11301673-537410.4103/1673-5374.3003231876-7958info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:48:49Zoai:repositorio.ul.pt:10451/46491Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:58:39.392352Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer’s disease : two triggers, one disease |
title |
Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer’s disease : two triggers, one disease |
spellingShingle |
Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer’s disease : two triggers, one disease Martins, Ivo C. Aggregation Alzheimer Amylin Amyloid Diabetes Islet amyloid polypeptide |
title_short |
Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer’s disease : two triggers, one disease |
title_full |
Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer’s disease : two triggers, one disease |
title_fullStr |
Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer’s disease : two triggers, one disease |
title_full_unstemmed |
Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer’s disease : two triggers, one disease |
title_sort |
Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer’s disease : two triggers, one disease |
author |
Martins, Ivo C. |
author_facet |
Martins, Ivo C. Menezes, Regina Ferreira, Sofia Raimundo, Ana F. |
author_role |
author |
author2 |
Menezes, Regina Ferreira, Sofia Raimundo, Ana F. |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Martins, Ivo C. Menezes, Regina Ferreira, Sofia Raimundo, Ana F. |
dc.subject.por.fl_str_mv |
Aggregation Alzheimer Amylin Amyloid Diabetes Islet amyloid polypeptide |
topic |
Aggregation Alzheimer Amylin Amyloid Diabetes Islet amyloid polypeptide |
description |
© Neural Regeneration Research. This is an open access journal, and articles are distributed under the terms of the Creative Commons AttributionNonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-02-23T13:42:35Z 2021 2021-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/46491 |
url |
http://hdl.handle.net/10451/46491 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Neural Regen Res. 2021 Jun;16(6):1127-1130 1673-5374 10.4103/1673-5374.300323 1876-7958 |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Wolters Kluwer |
publisher.none.fl_str_mv |
Wolters Kluwer |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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