Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer’s disease : two triggers, one disease

Detalhes bibliográficos
Autor(a) principal: Martins, Ivo C.
Data de Publicação: 2021
Outros Autores: Menezes, Regina, Ferreira, Sofia, Raimundo, Ana F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/46491
Resumo: © Neural Regeneration Research. This is an open access journal, and articles are distributed under the terms of the Creative Commons AttributionNonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
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spelling Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer’s disease : two triggers, one diseaseAggregationAlzheimerAmylinAmyloidDiabetesIslet amyloid polypeptide© Neural Regeneration Research. This is an open access journal, and articles are distributed under the terms of the Creative Commons AttributionNonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.Alzheimer’s disease (AD) is a neurodegenerative disorder that affects millions worldwide. Due to population ageing, the incidence of AD is increasing. AD patients develop cognitive decline and dementia, features for which is known, requiring permanent care. This poses a major socio-economic burden on healthcare systems as AD patients’ relatives and healthcare workers are forced to cope with rising numbers of affected people. Despite recent advances, AD pathological mechanisms are not fully understood. Nevertheless, it is clear that the amyloid beta (Aβ) peptide, which forms amyloid plaques in AD patients’ brains, plays a key role. Type 2 diabetes, the most common form of diabetes, affects hundreds of million people globally. Islet amyloid polypeptide (IAPP) is a hormone coproduced and secreted with insulin in pancreatic β-cells, with a key role in diabetes, as it helps regulate glucose levels and control adiposity and satiation. Similarly to Aβ, IAPP is very amyloidogenic, generating intracellular amyloid deposits that cause β-cell dysfunction and death. It is now clear that IAPP can also have a pathological role in AD, decreasing cognitive function. IAPP harms the blood-brain barrier, directly interacts and co-deposits with Aβ, promoting diabetes-associated dementia. IAPP can cause a metabolic dysfunction in the brain, leading to other diabetes-related forms of AD. Thus, here we discuss IAPP association with diabetes, Aβ and dementia, in the context of what we designate a “diabetes brain phenotype” AD hypothesis. Such approach helps to set a conceptual framework for future IAPP-based drugs against AD.This work was supported by iNOVA4Health – UID/Multi/04462/2019, a program financially supported by Fundação para a Ciência e Tecnologia/ Ministério da Educação e Ciência, through national funds and co-funded by FEDER under the PT2020 Partnership Agreement, Funding from INTERFACE Programme, through the Innovation, Technology and Circular Economy Fund (FITEC), FCT via PTDC/BIA-MOL/31104/2017 and UID/Multi/04462/2019-SubProj iNOVA4Health C44 (to RM), PD/BD/135504/2018 (to AFR), Sociedade Portuguesa de Diabetologia for the Nuno Castelo-Branco Prize – 2016 (to RM), and ICM acknowledges FCT-MCTES Program “Concurso de Estímulo ao Emprego Científico” (CEECIND/01670/2017)Wolters KluwerRepositório da Universidade de LisboaMartins, Ivo C.Menezes, ReginaFerreira, SofiaRaimundo, Ana F.2021-02-23T13:42:35Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/46491engNeural Regen Res. 2021 Jun;16(6):1127-11301673-537410.4103/1673-5374.3003231876-7958info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:48:49Zoai:repositorio.ul.pt:10451/46491Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:58:39.392352Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer’s disease : two triggers, one disease
title Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer’s disease : two triggers, one disease
spellingShingle Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer’s disease : two triggers, one disease
Martins, Ivo C.
Aggregation
Alzheimer
Amylin
Amyloid
Diabetes
Islet amyloid polypeptide
title_short Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer’s disease : two triggers, one disease
title_full Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer’s disease : two triggers, one disease
title_fullStr Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer’s disease : two triggers, one disease
title_full_unstemmed Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer’s disease : two triggers, one disease
title_sort Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer’s disease : two triggers, one disease
author Martins, Ivo C.
author_facet Martins, Ivo C.
Menezes, Regina
Ferreira, Sofia
Raimundo, Ana F.
author_role author
author2 Menezes, Regina
Ferreira, Sofia
Raimundo, Ana F.
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Martins, Ivo C.
Menezes, Regina
Ferreira, Sofia
Raimundo, Ana F.
dc.subject.por.fl_str_mv Aggregation
Alzheimer
Amylin
Amyloid
Diabetes
Islet amyloid polypeptide
topic Aggregation
Alzheimer
Amylin
Amyloid
Diabetes
Islet amyloid polypeptide
description © Neural Regeneration Research. This is an open access journal, and articles are distributed under the terms of the Creative Commons AttributionNonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
publishDate 2021
dc.date.none.fl_str_mv 2021-02-23T13:42:35Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/46491
url http://hdl.handle.net/10451/46491
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Neural Regen Res. 2021 Jun;16(6):1127-1130
1673-5374
10.4103/1673-5374.300323
1876-7958
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wolters Kluwer
publisher.none.fl_str_mv Wolters Kluwer
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799134532515921920

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