Neutrophil-to-eosinophil ratio and c-reactive protein are predictors of surgery in acute diverticulitis
Autor(a) principal: | |
---|---|
Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://revista.spcir.com/index.php/spcir/article/view/393 |
Resumo: | Background: Patients with acute diverticulitis (AD) and Hinchey<III may also need surgery. Therefore, as other markers are needed to help deciding which patients should be operated on, we tried to test the value of the C-reactive protein (CRP) and of blood cell count (and their ratios). Methods: Retrospective chart review of patients admitted to our surgical department between 2009 and 2011 with the diagnosis of AD. Only cases with a computed tomography confirmation were included in the study.Results: 174 patients (147 men, 27 women, age range 24-93 years) presented with AD. 161 patients had a modified Hinchey classification <III and 17 patients were submitted to surgery (7 had Hinchey III or IV and 10 had Hinchey<III). The neutrophil-to-eosinophil ratio (NER) had the best discriminant value in deciding for a surgical procedure in the ROC (receiver operating characteristics) curve. NER discriminated non-surgical and surgical treatment with an area under the ROC curve of 0.86 (95% confidence interval (CI), 0.79-0.92). The cut-off>244.25 yielded a sensitivity of 80% (95% CI, 44-98%), a specificity of 86% (95% CI, 79-92%), a positive likelihood ratio of 5.85 (95% CI, 3.40-10.10) and a negative likelihood ratio of 0.23 (95% CI, 0.07-0.80). In fact, NER>244.25 successfully predicted 15 out of 17 cases that were operated on in our sample. Conclusions: NER is a good marker in discriminating those that should be operated on regardless of the Hinchey category. However, more studies are needed to confirm these data. |
id |
RCAP_cec5c71a0c209096ffc6b5174c0c25bc |
---|---|
oai_identifier_str |
oai:revista.spcir.com:article/393 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Neutrophil-to-eosinophil ratio and c-reactive protein are predictors of surgery in acute diverticulitisBackground: Patients with acute diverticulitis (AD) and Hinchey<III may also need surgery. Therefore, as other markers are needed to help deciding which patients should be operated on, we tried to test the value of the C-reactive protein (CRP) and of blood cell count (and their ratios). Methods: Retrospective chart review of patients admitted to our surgical department between 2009 and 2011 with the diagnosis of AD. Only cases with a computed tomography confirmation were included in the study.Results: 174 patients (147 men, 27 women, age range 24-93 years) presented with AD. 161 patients had a modified Hinchey classification <III and 17 patients were submitted to surgery (7 had Hinchey III or IV and 10 had Hinchey<III). The neutrophil-to-eosinophil ratio (NER) had the best discriminant value in deciding for a surgical procedure in the ROC (receiver operating characteristics) curve. NER discriminated non-surgical and surgical treatment with an area under the ROC curve of 0.86 (95% confidence interval (CI), 0.79-0.92). The cut-off>244.25 yielded a sensitivity of 80% (95% CI, 44-98%), a specificity of 86% (95% CI, 79-92%), a positive likelihood ratio of 5.85 (95% CI, 3.40-10.10) and a negative likelihood ratio of 0.23 (95% CI, 0.07-0.80). In fact, NER>244.25 successfully predicted 15 out of 17 cases that were operated on in our sample. Conclusions: NER is a good marker in discriminating those that should be operated on regardless of the Hinchey category. However, more studies are needed to confirm these data.Sociedade Portuguesa de Cirurgia2015-06-29info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://revista.spcir.com/index.php/spcir/article/view/393Revista Portuguesa de Cirurgia; No 33 (2015): Number 33 - June 2015; 11-19Revista Portuguesa de Cirurgia; No 33 (2015): Number 33 - June 2015; 11-192183-11651646-6918reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://revista.spcir.com/index.php/spcir/article/view/393https://revista.spcir.com/index.php/spcir/article/view/393/390Copyright (c) 2016 Revista Portuguesa de Cirurgiainfo:eu-repo/semantics/openAccessMarcelino, GiselaCarvalho, NunoOliveira, GabrielMarialva, CelsoCampanha, RafaelaAlbergaria, DiogoSantos, CarlosLebre, RuiCorte-Real, João2024-03-14T22:05:05Zoai:revista.spcir.com:article/393Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T04:00:48.932768Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Neutrophil-to-eosinophil ratio and c-reactive protein are predictors of surgery in acute diverticulitis |
title |
Neutrophil-to-eosinophil ratio and c-reactive protein are predictors of surgery in acute diverticulitis |
spellingShingle |
Neutrophil-to-eosinophil ratio and c-reactive protein are predictors of surgery in acute diverticulitis Marcelino, Gisela |
title_short |
Neutrophil-to-eosinophil ratio and c-reactive protein are predictors of surgery in acute diverticulitis |
title_full |
Neutrophil-to-eosinophil ratio and c-reactive protein are predictors of surgery in acute diverticulitis |
title_fullStr |
Neutrophil-to-eosinophil ratio and c-reactive protein are predictors of surgery in acute diverticulitis |
title_full_unstemmed |
Neutrophil-to-eosinophil ratio and c-reactive protein are predictors of surgery in acute diverticulitis |
title_sort |
Neutrophil-to-eosinophil ratio and c-reactive protein are predictors of surgery in acute diverticulitis |
author |
Marcelino, Gisela |
author_facet |
Marcelino, Gisela Carvalho, Nuno Oliveira, Gabriel Marialva, Celso Campanha, Rafaela Albergaria, Diogo Santos, Carlos Lebre, Rui Corte-Real, João |
author_role |
author |
author2 |
Carvalho, Nuno Oliveira, Gabriel Marialva, Celso Campanha, Rafaela Albergaria, Diogo Santos, Carlos Lebre, Rui Corte-Real, João |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Marcelino, Gisela Carvalho, Nuno Oliveira, Gabriel Marialva, Celso Campanha, Rafaela Albergaria, Diogo Santos, Carlos Lebre, Rui Corte-Real, João |
description |
Background: Patients with acute diverticulitis (AD) and Hinchey<III may also need surgery. Therefore, as other markers are needed to help deciding which patients should be operated on, we tried to test the value of the C-reactive protein (CRP) and of blood cell count (and their ratios). Methods: Retrospective chart review of patients admitted to our surgical department between 2009 and 2011 with the diagnosis of AD. Only cases with a computed tomography confirmation were included in the study.Results: 174 patients (147 men, 27 women, age range 24-93 years) presented with AD. 161 patients had a modified Hinchey classification <III and 17 patients were submitted to surgery (7 had Hinchey III or IV and 10 had Hinchey<III). The neutrophil-to-eosinophil ratio (NER) had the best discriminant value in deciding for a surgical procedure in the ROC (receiver operating characteristics) curve. NER discriminated non-surgical and surgical treatment with an area under the ROC curve of 0.86 (95% confidence interval (CI), 0.79-0.92). The cut-off>244.25 yielded a sensitivity of 80% (95% CI, 44-98%), a specificity of 86% (95% CI, 79-92%), a positive likelihood ratio of 5.85 (95% CI, 3.40-10.10) and a negative likelihood ratio of 0.23 (95% CI, 0.07-0.80). In fact, NER>244.25 successfully predicted 15 out of 17 cases that were operated on in our sample. Conclusions: NER is a good marker in discriminating those that should be operated on regardless of the Hinchey category. However, more studies are needed to confirm these data. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-06-29 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://revista.spcir.com/index.php/spcir/article/view/393 |
url |
https://revista.spcir.com/index.php/spcir/article/view/393 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://revista.spcir.com/index.php/spcir/article/view/393 https://revista.spcir.com/index.php/spcir/article/view/393/390 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2016 Revista Portuguesa de Cirurgia info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2016 Revista Portuguesa de Cirurgia |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Cirurgia |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Cirurgia |
dc.source.none.fl_str_mv |
Revista Portuguesa de Cirurgia; No 33 (2015): Number 33 - June 2015; 11-19 Revista Portuguesa de Cirurgia; No 33 (2015): Number 33 - June 2015; 11-19 2183-1165 1646-6918 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799138182789332992 |