Early pseudoprogression following chemoradiotherapy in glioblastoma patients: the value of RANO evaluation

Detalhes bibliográficos
Autor(a) principal: Reis, R. M.
Data de Publicação: 2013
Outros Autores: Linhares, Paulo, Carvalho, Bruno, Figueiredo, Rita, Vaz, Rui
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/25962
Resumo: Early Pseudo-progression Following Chemoradiotherapy in Glioblastoma Patients: The Value of RANO Evaluation
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spelling Early pseudoprogression following chemoradiotherapy in glioblastoma patients: the value of RANO evaluationScience & TechnologyEarly Pseudo-progression Following Chemoradiotherapy in Glioblastoma Patients: The Value of RANO EvaluationThe aim of this study was to determine the frequency of pseudoprogression in a cohort of glioblastoma (GBM) patients following radiotherapy/temozolomide (RT/TMZ) by comparing Macdonald criterial to Response Assessment in Neuro-Oncology (RANO) criteria. The impact on prognosis and survival analysis was also studied. Materials and Methods. All patients receiving RT/TMZ for newly diagnosed GBM from January 2005 to December 2009 were retrospectively evaluated, and demographic, clinical, radiographic, treatment, and survival data were reviewed. Updated RANO criteria were used for the evaluation of the pre-RT and post-RT MRI and compared to classic Macdonald criteria. Survival data was evaluated using the Kaplan-Meier and log-rank analysis. Results and Discussion. 70 patients were available for full radiological response assessment. Early progression was confirmed in 42 patients (60%) according to Macdonald criteria and 15 patients (21%) according to RANO criteria. Pseudoprogression was identified in 10 (23.8%) or 2 (13.3%) patients in Macdonald and RANO groups, respectively. Cumulative survival of pseudoprogression group was higher than that of true progression group and not statistically different from the non-progressive disease group. Conclusion. In this cohort, the frequency of pseudoprogression varied between 13% and 24%, being overdiagnosed by older Macdonald criteria, which emphasizes the importance of RANO criteria and new radiological biomarkers for correct response evaluation.The authors acknowledge Francisco Soares, MD, for statistical support.Hindawi Publishing CorporationUniversidade do MinhoReis, R. M.Linhares, PauloCarvalho, BrunoFigueiredo, RitaVaz, Rui20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/25962eng1687-845010.1155/2013/690585http://www.hindawi.com/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T11:56:23Zoai:repositorium.sdum.uminho.pt:1822/25962Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:45:58.869602Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Early pseudoprogression following chemoradiotherapy in glioblastoma patients: the value of RANO evaluation
title Early pseudoprogression following chemoradiotherapy in glioblastoma patients: the value of RANO evaluation
spellingShingle Early pseudoprogression following chemoradiotherapy in glioblastoma patients: the value of RANO evaluation
Reis, R. M.
Science & Technology
title_short Early pseudoprogression following chemoradiotherapy in glioblastoma patients: the value of RANO evaluation
title_full Early pseudoprogression following chemoradiotherapy in glioblastoma patients: the value of RANO evaluation
title_fullStr Early pseudoprogression following chemoradiotherapy in glioblastoma patients: the value of RANO evaluation
title_full_unstemmed Early pseudoprogression following chemoradiotherapy in glioblastoma patients: the value of RANO evaluation
title_sort Early pseudoprogression following chemoradiotherapy in glioblastoma patients: the value of RANO evaluation
author Reis, R. M.
author_facet Reis, R. M.
Linhares, Paulo
Carvalho, Bruno
Figueiredo, Rita
Vaz, Rui
author_role author
author2 Linhares, Paulo
Carvalho, Bruno
Figueiredo, Rita
Vaz, Rui
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Reis, R. M.
Linhares, Paulo
Carvalho, Bruno
Figueiredo, Rita
Vaz, Rui
dc.subject.por.fl_str_mv Science & Technology
topic Science & Technology
description Early Pseudo-progression Following Chemoradiotherapy in Glioblastoma Patients: The Value of RANO Evaluation
publishDate 2013
dc.date.none.fl_str_mv 2013
2013-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/25962
url http://hdl.handle.net/1822/25962
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1687-8450
10.1155/2013/690585
http://www.hindawi.com/
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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