The role of human papillomavirus in head and neck tumors

• Autor(a) principal: Saraiva, Nadine
• Data de Publicação: 2017
• Outros Autores: Rodrigues, Joana, Bonito, Nuno, Prazeres, Hugo, Cruz, Eugénia, Costa, Miguel, Teixeira, Margarida, Silva, Regina, Gervásio, Helena
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: https://doi.org/10.34631/sporl.624
• topic: Human Papilloma Virus; tumors of the head and neck; DNA; alcohol; tobacco; Papiloma Vírus Humano; tumores da cabeça e pescoço; DNA; álcool; tabaco

The human papillomavirus (HPV) infection is a risk factor for the development of tumors of the head and neck. We intend to assess the prevalence of HPV in these tumors in patients without alcohol and tobacco risk factors.The presence of HPV DNA was tested by PCR (Polymerase Chain Reaction) in all patients with head and neck tumor identified between 2010 and 2013.44 patients with a mean age of 61.4 years were identified, with a predominance of males. 6 of these patients were HPV-DNA positive, of which 50.0% had a stage IVA. 66.7% underwent surgery and the remaining systemic therapy. The HPV-DNA positive population’s overall survival at 12 and 60 months was 100% and 50%, respectively and the HPV-DNA negative population’s overall survival was 86.8% and 15.8%, respectively.In our population, 13.6% of patients were positive for DNAHPV, which is comparable to published studies.