Systematic review of the application of perinatal derivatives in animal models on cutaneous wound healing
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.1/17269 |
Resumo: | Knowledge of the beneficial effects of perinatal derivatives (PnD) in wound healing goes back to the early 1900s when the human fetal amniotic membrane served as a biological dressing to treat burns and skin ulcerations. Since the twenty-first century, isolated cells from perinatal tissues and their secretomes have gained increasing scientific interest, as they can be obtained non-invasively, have anti-inflammatory, anti-cancer, and anti-fibrotic characteristics, and are immunologically tolerated in vivo. Many studies that apply PnD in pre-clinical cutaneous wound healing models show large variations in the choice of the animal species (e.g., large animals, rodents), the choice of diabetic or non-diabetic animals, the type of injury (full-thickness wounds, burns, radiation-induced wounds, skin flaps), the source and type of PnD (placenta, umbilical cord, fetal membranes, cells, secretomes, tissue extracts), the method of administration (topical application, intradermal/ subcutaneous injection, intravenous or intraperitoneal injection, subcutaneous implantation), and the type of delivery systems (e.g., hydrogels, synthetic or natural biomaterials as carriers for transplanted cells, extracts or secretomes). This review provides a comprehensive and integrative overview of the application of PnD in wound healing to assess its efficacy in preclinical animal models. We highlight the advantages and limitations of the most commonly used animal models and evaluate the impact of the type of PnD, the route of administration, and the dose of cells/secretome application in correlation with the wound healing outcome. This review is a collaborative effort from the COST SPRINT Action (CA17116), which broadly aims at approaching consensus for different aspects of PnD research, such as providing inputs for future standards for the preclinical application of PnD in wound healing . |
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Systematic review of the application of perinatal derivatives in animal models on cutaneous wound healingRevisão sistemática da aplicação de derivados perinatais em modelos animais em cicatriz cutâneaPerinatal derivativesPlacentaCellsPreclinical studiesAnimal modelsWound healingSkinCutaneousKnowledge of the beneficial effects of perinatal derivatives (PnD) in wound healing goes back to the early 1900s when the human fetal amniotic membrane served as a biological dressing to treat burns and skin ulcerations. Since the twenty-first century, isolated cells from perinatal tissues and their secretomes have gained increasing scientific interest, as they can be obtained non-invasively, have anti-inflammatory, anti-cancer, and anti-fibrotic characteristics, and are immunologically tolerated in vivo. Many studies that apply PnD in pre-clinical cutaneous wound healing models show large variations in the choice of the animal species (e.g., large animals, rodents), the choice of diabetic or non-diabetic animals, the type of injury (full-thickness wounds, burns, radiation-induced wounds, skin flaps), the source and type of PnD (placenta, umbilical cord, fetal membranes, cells, secretomes, tissue extracts), the method of administration (topical application, intradermal/ subcutaneous injection, intravenous or intraperitoneal injection, subcutaneous implantation), and the type of delivery systems (e.g., hydrogels, synthetic or natural biomaterials as carriers for transplanted cells, extracts or secretomes). This review provides a comprehensive and integrative overview of the application of PnD in wound healing to assess its efficacy in preclinical animal models. We highlight the advantages and limitations of the most commonly used animal models and evaluate the impact of the type of PnD, the route of administration, and the dose of cells/secretome application in correlation with the wound healing outcome. This review is a collaborative effort from the COST SPRINT Action (CA17116), which broadly aims at approaching consensus for different aspects of PnD research, such as providing inputs for future standards for the preclinical application of PnD in wound healing .Frontiers MediaSapientiaPichlsberger, MelanieJerman, Urška DraginObradović, HristinaTratnjek, LarisaMacedo, Ana SofiaMendes, FranciscaFonte, PedroHoegler, AnjaSundl, MonikaFuchs, JuliaSchoeberlein, AndreinaKreft, Mateja ErdaniMojsilović, SlavkoLang-Olip, Ingrid2021-10-29T14:48:34Z2021-092021-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/17269eng2296-418510.3389/fbioe.2021.742858info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:29:25Zoai:sapientia.ualg.pt:10400.1/17269Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:07:17.742854Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Systematic review of the application of perinatal derivatives in animal models on cutaneous wound healing Revisão sistemática da aplicação de derivados perinatais em modelos animais em cicatriz cutânea |
title |
Systematic review of the application of perinatal derivatives in animal models on cutaneous wound healing |
spellingShingle |
Systematic review of the application of perinatal derivatives in animal models on cutaneous wound healing Pichlsberger, Melanie Perinatal derivatives Placenta Cells Preclinical studies Animal models Wound healing Skin Cutaneous |
title_short |
Systematic review of the application of perinatal derivatives in animal models on cutaneous wound healing |
title_full |
Systematic review of the application of perinatal derivatives in animal models on cutaneous wound healing |
title_fullStr |
Systematic review of the application of perinatal derivatives in animal models on cutaneous wound healing |
title_full_unstemmed |
Systematic review of the application of perinatal derivatives in animal models on cutaneous wound healing |
title_sort |
Systematic review of the application of perinatal derivatives in animal models on cutaneous wound healing |
author |
Pichlsberger, Melanie |
author_facet |
Pichlsberger, Melanie Jerman, Urška Dragin Obradović, Hristina Tratnjek, Larisa Macedo, Ana Sofia Mendes, Francisca Fonte, Pedro Hoegler, Anja Sundl, Monika Fuchs, Julia Schoeberlein, Andreina Kreft, Mateja Erdani Mojsilović, Slavko Lang-Olip, Ingrid |
author_role |
author |
author2 |
Jerman, Urška Dragin Obradović, Hristina Tratnjek, Larisa Macedo, Ana Sofia Mendes, Francisca Fonte, Pedro Hoegler, Anja Sundl, Monika Fuchs, Julia Schoeberlein, Andreina Kreft, Mateja Erdani Mojsilović, Slavko Lang-Olip, Ingrid |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Sapientia |
dc.contributor.author.fl_str_mv |
Pichlsberger, Melanie Jerman, Urška Dragin Obradović, Hristina Tratnjek, Larisa Macedo, Ana Sofia Mendes, Francisca Fonte, Pedro Hoegler, Anja Sundl, Monika Fuchs, Julia Schoeberlein, Andreina Kreft, Mateja Erdani Mojsilović, Slavko Lang-Olip, Ingrid |
dc.subject.por.fl_str_mv |
Perinatal derivatives Placenta Cells Preclinical studies Animal models Wound healing Skin Cutaneous |
topic |
Perinatal derivatives Placenta Cells Preclinical studies Animal models Wound healing Skin Cutaneous |
description |
Knowledge of the beneficial effects of perinatal derivatives (PnD) in wound healing goes back to the early 1900s when the human fetal amniotic membrane served as a biological dressing to treat burns and skin ulcerations. Since the twenty-first century, isolated cells from perinatal tissues and their secretomes have gained increasing scientific interest, as they can be obtained non-invasively, have anti-inflammatory, anti-cancer, and anti-fibrotic characteristics, and are immunologically tolerated in vivo. Many studies that apply PnD in pre-clinical cutaneous wound healing models show large variations in the choice of the animal species (e.g., large animals, rodents), the choice of diabetic or non-diabetic animals, the type of injury (full-thickness wounds, burns, radiation-induced wounds, skin flaps), the source and type of PnD (placenta, umbilical cord, fetal membranes, cells, secretomes, tissue extracts), the method of administration (topical application, intradermal/ subcutaneous injection, intravenous or intraperitoneal injection, subcutaneous implantation), and the type of delivery systems (e.g., hydrogels, synthetic or natural biomaterials as carriers for transplanted cells, extracts or secretomes). This review provides a comprehensive and integrative overview of the application of PnD in wound healing to assess its efficacy in preclinical animal models. We highlight the advantages and limitations of the most commonly used animal models and evaluate the impact of the type of PnD, the route of administration, and the dose of cells/secretome application in correlation with the wound healing outcome. This review is a collaborative effort from the COST SPRINT Action (CA17116), which broadly aims at approaching consensus for different aspects of PnD research, such as providing inputs for future standards for the preclinical application of PnD in wound healing . |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-10-29T14:48:34Z 2021-09 2021-09-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.1/17269 |
url |
http://hdl.handle.net/10400.1/17269 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2296-4185 10.3389/fbioe.2021.742858 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media |
publisher.none.fl_str_mv |
Frontiers Media |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133317587533824 |