Hormonal regulation of c-KIT receptor and its ligand: implications for human infertility?

Detalhes bibliográficos
Autor(a) principal: Figueira, Marília I
Data de Publicação: 2014
Outros Autores: Cardoso, HJ, Correia, Sara, Baptista, Cláudio, Socorro, Sílvia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.6/7651
Resumo: The c-KIT, a tyrosine kinase receptor, and its ligand the stem cell factor (SCF) play an important role in the production of male and female gametes. The interaction of SCF with c-KIT is required for germ cell survival and growth, and abnormalities in the activity of the SCF/c-KIT system have been associated with human infertility. Recently, it was demonstrated that gonadotropic and sex steroid hormones, among others, regulate the expression of SCF and c-KIT in testicular and ovarian cells. Therefore, the hormonal (de)regulation of SCF/c-KIT system in the testis and ovary may be a cause underpinning infertility. In the present review, we will discuss the effects of hormones modulating the expression levels of SCF and c-KIT in the human gonads. In addition, the implications of hormonal regulation of SCF/c-KIT system for germ cell development and fertility will be highlighted.
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spelling Hormonal regulation of c-KIT receptor and its ligand: implications for human infertility?Androgensc-KITEstrogensGonadotropinsInfertilityThe c-KIT, a tyrosine kinase receptor, and its ligand the stem cell factor (SCF) play an important role in the production of male and female gametes. The interaction of SCF with c-KIT is required for germ cell survival and growth, and abnormalities in the activity of the SCF/c-KIT system have been associated with human infertility. Recently, it was demonstrated that gonadotropic and sex steroid hormones, among others, regulate the expression of SCF and c-KIT in testicular and ovarian cells. Therefore, the hormonal (de)regulation of SCF/c-KIT system in the testis and ovary may be a cause underpinning infertility. In the present review, we will discuss the effects of hormones modulating the expression levels of SCF and c-KIT in the human gonads. In addition, the implications of hormonal regulation of SCF/c-KIT system for germ cell development and fertility will be highlighted.uBibliorumFigueira, Marília ICardoso, HJCorreia, SaraBaptista, CláudioSocorro, Sílvia2019-12-02T17:16:45Z2014-092014-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/7651eng10.1016/j.proghi.2014.09.001metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-15T09:47:11Zoai:ubibliorum.ubi.pt:10400.6/7651Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:48:07.482938Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Hormonal regulation of c-KIT receptor and its ligand: implications for human infertility?
title Hormonal regulation of c-KIT receptor and its ligand: implications for human infertility?
spellingShingle Hormonal regulation of c-KIT receptor and its ligand: implications for human infertility?
Figueira, Marília I
Androgens
c-KIT
Estrogens
Gonadotropins
Infertility
title_short Hormonal regulation of c-KIT receptor and its ligand: implications for human infertility?
title_full Hormonal regulation of c-KIT receptor and its ligand: implications for human infertility?
title_fullStr Hormonal regulation of c-KIT receptor and its ligand: implications for human infertility?
title_full_unstemmed Hormonal regulation of c-KIT receptor and its ligand: implications for human infertility?
title_sort Hormonal regulation of c-KIT receptor and its ligand: implications for human infertility?
author Figueira, Marília I
author_facet Figueira, Marília I
Cardoso, HJ
Correia, Sara
Baptista, Cláudio
Socorro, Sílvia
author_role author
author2 Cardoso, HJ
Correia, Sara
Baptista, Cláudio
Socorro, Sílvia
author2_role author
author
author
author
dc.contributor.none.fl_str_mv uBibliorum
dc.contributor.author.fl_str_mv Figueira, Marília I
Cardoso, HJ
Correia, Sara
Baptista, Cláudio
Socorro, Sílvia
dc.subject.por.fl_str_mv Androgens
c-KIT
Estrogens
Gonadotropins
Infertility
topic Androgens
c-KIT
Estrogens
Gonadotropins
Infertility
description The c-KIT, a tyrosine kinase receptor, and its ligand the stem cell factor (SCF) play an important role in the production of male and female gametes. The interaction of SCF with c-KIT is required for germ cell survival and growth, and abnormalities in the activity of the SCF/c-KIT system have been associated with human infertility. Recently, it was demonstrated that gonadotropic and sex steroid hormones, among others, regulate the expression of SCF and c-KIT in testicular and ovarian cells. Therefore, the hormonal (de)regulation of SCF/c-KIT system in the testis and ovary may be a cause underpinning infertility. In the present review, we will discuss the effects of hormones modulating the expression levels of SCF and c-KIT in the human gonads. In addition, the implications of hormonal regulation of SCF/c-KIT system for germ cell development and fertility will be highlighted.
publishDate 2014
dc.date.none.fl_str_mv 2014-09
2014-09-01T00:00:00Z
2019-12-02T17:16:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.6/7651
url http://hdl.handle.net/10400.6/7651
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.proghi.2014.09.001
dc.rights.driver.fl_str_mv metadata only access
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eu_rights_str_mv openAccess
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instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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