Strategies for re-vascularization and promotion of angiogenesis in trauma and disease

Detalhes bibliográficos
Autor(a) principal: Gonçalves, Raquel C.
Data de Publicação: 2021
Outros Autores: Banfi, Andrea, Oliveira, Mariana B., Mano, João F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10773/34392
Resumo: The maintenance of a healthy vascular system is essential to ensure the proper function of all organs of the human body. While macrovessels have the main role of blood transportation from the heart to all tissues, microvessels, in particular capillaries, are responsible for maintaining tissues' functionality by providing oxygen, nutrients and waste exchanges. Occlusion of blood vessels due to atherosclerotic plaque accumulation remains the leading cause of mortality across the world. Autologous vein and artery grafts bypassing are the current gold standard surgical procedures to substitute primarily obstructed vascular structures. Ischemic scenarios that condition blood supply in downstream tissues may arise from blockage phenomena, as well as from other disease or events leading to trauma. The (i) great demand for new vascular substitutes, arising from both the limited availability of healthy autologous vessels, as well as the shortcomings associated with small-diameter synthetic vascular grafts, and (ii) the challenging induction of the formation of adequate and stable microvasculature are current driving forces for the growing interest in the development of bioinspired strategies to ensure the proper function of vasculature in all its dimensional scales. Here, a critical review of well-established technologies and recent biotechnological advances to substitute or regenerate the vascular system is provided.
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spelling Strategies for re-vascularization and promotion of angiogenesis in trauma and diseaseVascular graftMicrovasculatureBiomaterialsVasculogenesisAngiogenesisThe maintenance of a healthy vascular system is essential to ensure the proper function of all organs of the human body. While macrovessels have the main role of blood transportation from the heart to all tissues, microvessels, in particular capillaries, are responsible for maintaining tissues' functionality by providing oxygen, nutrients and waste exchanges. Occlusion of blood vessels due to atherosclerotic plaque accumulation remains the leading cause of mortality across the world. Autologous vein and artery grafts bypassing are the current gold standard surgical procedures to substitute primarily obstructed vascular structures. Ischemic scenarios that condition blood supply in downstream tissues may arise from blockage phenomena, as well as from other disease or events leading to trauma. The (i) great demand for new vascular substitutes, arising from both the limited availability of healthy autologous vessels, as well as the shortcomings associated with small-diameter synthetic vascular grafts, and (ii) the challenging induction of the formation of adequate and stable microvasculature are current driving forces for the growing interest in the development of bioinspired strategies to ensure the proper function of vasculature in all its dimensional scales. Here, a critical review of well-established technologies and recent biotechnological advances to substitute or regenerate the vascular system is provided.Elsevier2021-022021-02-01T00:00:00Z2023-02-28T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/34392eng0142-961210.1016/j.biomaterials.2020.120628Gonçalves, Raquel C.Banfi, AndreaOliveira, Mariana B.Mano, João F.info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T12:06:27Zoai:ria.ua.pt:10773/34392Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:05:44.466217Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Strategies for re-vascularization and promotion of angiogenesis in trauma and disease
title Strategies for re-vascularization and promotion of angiogenesis in trauma and disease
spellingShingle Strategies for re-vascularization and promotion of angiogenesis in trauma and disease
Gonçalves, Raquel C.
Vascular graft
Microvasculature
Biomaterials
Vasculogenesis
Angiogenesis
title_short Strategies for re-vascularization and promotion of angiogenesis in trauma and disease
title_full Strategies for re-vascularization and promotion of angiogenesis in trauma and disease
title_fullStr Strategies for re-vascularization and promotion of angiogenesis in trauma and disease
title_full_unstemmed Strategies for re-vascularization and promotion of angiogenesis in trauma and disease
title_sort Strategies for re-vascularization and promotion of angiogenesis in trauma and disease
author Gonçalves, Raquel C.
author_facet Gonçalves, Raquel C.
Banfi, Andrea
Oliveira, Mariana B.
Mano, João F.
author_role author
author2 Banfi, Andrea
Oliveira, Mariana B.
Mano, João F.
author2_role author
author
author
dc.contributor.author.fl_str_mv Gonçalves, Raquel C.
Banfi, Andrea
Oliveira, Mariana B.
Mano, João F.
dc.subject.por.fl_str_mv Vascular graft
Microvasculature
Biomaterials
Vasculogenesis
Angiogenesis
topic Vascular graft
Microvasculature
Biomaterials
Vasculogenesis
Angiogenesis
description The maintenance of a healthy vascular system is essential to ensure the proper function of all organs of the human body. While macrovessels have the main role of blood transportation from the heart to all tissues, microvessels, in particular capillaries, are responsible for maintaining tissues' functionality by providing oxygen, nutrients and waste exchanges. Occlusion of blood vessels due to atherosclerotic plaque accumulation remains the leading cause of mortality across the world. Autologous vein and artery grafts bypassing are the current gold standard surgical procedures to substitute primarily obstructed vascular structures. Ischemic scenarios that condition blood supply in downstream tissues may arise from blockage phenomena, as well as from other disease or events leading to trauma. The (i) great demand for new vascular substitutes, arising from both the limited availability of healthy autologous vessels, as well as the shortcomings associated with small-diameter synthetic vascular grafts, and (ii) the challenging induction of the formation of adequate and stable microvasculature are current driving forces for the growing interest in the development of bioinspired strategies to ensure the proper function of vasculature in all its dimensional scales. Here, a critical review of well-established technologies and recent biotechnological advances to substitute or regenerate the vascular system is provided.
publishDate 2021
dc.date.none.fl_str_mv 2021-02
2021-02-01T00:00:00Z
2023-02-28T00:00:00Z
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10773/34392
url http://hdl.handle.net/10773/34392
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0142-9612
10.1016/j.biomaterials.2020.120628
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
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