A theory for bone resorption based on the local rupture of osteocytes cells connections: A finite element study

Detalhes bibliográficos
Autor(a) principal: Ridha Hambli
Data de Publicação: 2015
Outros Autores: Khalid H. Almitani, Abdessalem Chamekh, Hechmi Toumi, João Manuel R. S. Tavares
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/78109
Resumo: In this work, a bone damage resorption finite element model based on the disruption of the inhibitory signal transmitted between osteocytes cells in bone due to damage accumulation is developed and discussed. A strain-based stimulus function coupled to a damage-dependent spatial function is proposed to represent the connection between two osteocytes embedded in the bone tissue. The signal is transmitted to the bone surface to activate bone resorption. The proposed model is based on the idea that the osteocyte signal reduction is not related to the reduction of the stimulus sensed locally by osteocytes due to damage, but to the difficulties for the signal in travelling along a disrupted area due to microcracks that can destroy connections of the intercellular network between osteocytes and bone-lining cells. To check the potential of the proposed model to predict the damage resorption process, two bone resorption mechano-regulation rules corresponding to two mechanotransduction approaches have been implemented and tested: (1) Bone resorption based on a coupled strain-damage stimulus function without ruptured osteocyte connections (NROC); and (2) Bone resorption based on a strain stimulus function with ruptured osteocyte connections (ROC). The comparison between the results obtained by both models, shows that the proposed model based on ruptured osteocytes connections predicts realistic results in conformity with previously published findings concerning the fatigue damage repair in bone.
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spelling A theory for bone resorption based on the local rupture of osteocytes cells connections: A finite element studyCiências Tecnológicas, Ciências da engenharia e tecnologiasTechnological sciences, Engineering and technologyIn this work, a bone damage resorption finite element model based on the disruption of the inhibitory signal transmitted between osteocytes cells in bone due to damage accumulation is developed and discussed. A strain-based stimulus function coupled to a damage-dependent spatial function is proposed to represent the connection between two osteocytes embedded in the bone tissue. The signal is transmitted to the bone surface to activate bone resorption. The proposed model is based on the idea that the osteocyte signal reduction is not related to the reduction of the stimulus sensed locally by osteocytes due to damage, but to the difficulties for the signal in travelling along a disrupted area due to microcracks that can destroy connections of the intercellular network between osteocytes and bone-lining cells. To check the potential of the proposed model to predict the damage resorption process, two bone resorption mechano-regulation rules corresponding to two mechanotransduction approaches have been implemented and tested: (1) Bone resorption based on a coupled strain-damage stimulus function without ruptured osteocyte connections (NROC); and (2) Bone resorption based on a strain stimulus function with ruptured osteocyte connections (ROC). The comparison between the results obtained by both models, shows that the proposed model based on ruptured osteocytes connections predicts realistic results in conformity with previously published findings concerning the fatigue damage repair in bone.20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/78109eng0025-556410.1016/j.mbs.2015.01.005Ridha HambliKhalid H. AlmitaniAbdessalem ChamekhHechmi ToumiJoão Manuel R. S. Tavaresinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T15:22:48Zoai:repositorio-aberto.up.pt:10216/78109Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:22:10.378888Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A theory for bone resorption based on the local rupture of osteocytes cells connections: A finite element study
title A theory for bone resorption based on the local rupture of osteocytes cells connections: A finite element study
spellingShingle A theory for bone resorption based on the local rupture of osteocytes cells connections: A finite element study
Ridha Hambli
Ciências Tecnológicas, Ciências da engenharia e tecnologias
Technological sciences, Engineering and technology
title_short A theory for bone resorption based on the local rupture of osteocytes cells connections: A finite element study
title_full A theory for bone resorption based on the local rupture of osteocytes cells connections: A finite element study
title_fullStr A theory for bone resorption based on the local rupture of osteocytes cells connections: A finite element study
title_full_unstemmed A theory for bone resorption based on the local rupture of osteocytes cells connections: A finite element study
title_sort A theory for bone resorption based on the local rupture of osteocytes cells connections: A finite element study
author Ridha Hambli
author_facet Ridha Hambli
Khalid H. Almitani
Abdessalem Chamekh
Hechmi Toumi
João Manuel R. S. Tavares
author_role author
author2 Khalid H. Almitani
Abdessalem Chamekh
Hechmi Toumi
João Manuel R. S. Tavares
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Ridha Hambli
Khalid H. Almitani
Abdessalem Chamekh
Hechmi Toumi
João Manuel R. S. Tavares
dc.subject.por.fl_str_mv Ciências Tecnológicas, Ciências da engenharia e tecnologias
Technological sciences, Engineering and technology
topic Ciências Tecnológicas, Ciências da engenharia e tecnologias
Technological sciences, Engineering and technology
description In this work, a bone damage resorption finite element model based on the disruption of the inhibitory signal transmitted between osteocytes cells in bone due to damage accumulation is developed and discussed. A strain-based stimulus function coupled to a damage-dependent spatial function is proposed to represent the connection between two osteocytes embedded in the bone tissue. The signal is transmitted to the bone surface to activate bone resorption. The proposed model is based on the idea that the osteocyte signal reduction is not related to the reduction of the stimulus sensed locally by osteocytes due to damage, but to the difficulties for the signal in travelling along a disrupted area due to microcracks that can destroy connections of the intercellular network between osteocytes and bone-lining cells. To check the potential of the proposed model to predict the damage resorption process, two bone resorption mechano-regulation rules corresponding to two mechanotransduction approaches have been implemented and tested: (1) Bone resorption based on a coupled strain-damage stimulus function without ruptured osteocyte connections (NROC); and (2) Bone resorption based on a strain stimulus function with ruptured osteocyte connections (ROC). The comparison between the results obtained by both models, shows that the proposed model based on ruptured osteocytes connections predicts realistic results in conformity with previously published findings concerning the fatigue damage repair in bone.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/78109
url https://hdl.handle.net/10216/78109
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0025-5564
10.1016/j.mbs.2015.01.005
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dc.format.none.fl_str_mv application/pdf
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instacron:RCAAP
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