Estudo do nível de função cognitiva e de atividade física e o impacto na qualidade de vida de sobreviventes de cancro da mama

• Autor(a) principal: Andreia Filipa Teixeira de Carvalho
• Data de Publicação: 2019
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: https://hdl.handle.net/10216/121444
• topic: Outras ciências sociais; Other social sciences

Cancer treatment-related cognitive impairment (CRCI) is frequently reported in breast cancer survivors. Physical exercise has been described as a non-pharmacological strategy to attenuate most of the side effects, particularly the cognitive function decline. Therefore, we aimed to evaluate physical activity status and cognitive function among breast cancers survivors and their association with quality of life (QoL). The present study was developed in Mama Help, Porto, a Breast Cancer Support Association. Women with a breast cancer diagnosis (n=29, aged between [34 -80years] and sub-divided in 3 groups: Without quimio-control; Quimio; Post-Quimio) were recruited and participated in the present study after signing the informed consent. The International Physical Activity Questionnaire (IPAQ) was used in all included volunteers to register the three intensity levels of physical activity - vigorous and moderate-intensity activity and/or walking. Data were converted to Metabolic Equivalent minutes per week (MET, min/week). The QoL and the CRCI were evaluated using the Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog) questionnaire. Although without statistically significance alterations, a moderate-sized effect (ES) for total score FACT-Cog was observed in women during chemotherapy (ES=0.4; 37.0 [8.3-65.7]) and in post-chemotherapy (ES=0.5; 36.2 [19.9-52.6] groups compared to no-chemotherapy group (46.6 [-10.5-103.9]). No associations between age, total score FACT-Cog or its domains (p>0.05), but a positive correlation between perceived cognitive abilities and months of diagnosis was observed (r=0.507; p=0.05). A large-sized effect (ES=0.93; 1315 [279.9-2350] vs.733.4 [462.2-1002.6]) was found in METs between current chemotherapy vs. no-chemotherapy groups. A moderate-sized effect in total score FACT-Cog (ES=0.5; 41.6 [28-54.6] vs. 30.5 [3.4-57.5]) and in QoL (ES=0.4; 14.5 [7.2-18.9] vs. 10.3 [-1.9-22.7]) were observed in active group vs. inactive group. Data from this study provide evidence for the presence of cognitive complaints and poor physical activity status in women undergone chemotherapy, which likely reflect on a negative impact on QoL.