Decrease of E-cadherin expression in canine cutaneous histiocytoma appears to be related to its spontaneous regression.
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10348/2747 |
Resumo: | Background: Canine cutaneous histiocytoma (CCH) is an epidermotropic tumour of Langerhans cells, most frequent in young dogs, which undergoes spontaneous regression. Materials and Methods: E-cadherin immunoexpression was analysed in ninety-three CCH, categorized according to Cockerell and Slauson (1976) criteria into four histological groups, representing different stages of tumour regression. Results: All tumours expressed membranous Ecadherin both in keratinocytes, and in tumoural cells and no differences were noted among the histological groups analysed.However, the intensity of the E-cadherin immunolabeling decreased in the presence of lymphoid infiltration and varied significantly among the groups considered (p<0.0001).Conclusion: This study strongly suggests a down-regulation of E-cadherin expression in CCH pathogenesis and progression.The loss of E-cadherin expression might represent an activation/ maturation process of the tumoural cells constituting a switch for CCH regression |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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Decrease of E-cadherin expression in canine cutaneous histiocytoma appears to be related to its spontaneous regression.Canine cutaneous histiocytomaE-cadherinimmunohistochemistrytumour regressionBackground: Canine cutaneous histiocytoma (CCH) is an epidermotropic tumour of Langerhans cells, most frequent in young dogs, which undergoes spontaneous regression. Materials and Methods: E-cadherin immunoexpression was analysed in ninety-three CCH, categorized according to Cockerell and Slauson (1976) criteria into four histological groups, representing different stages of tumour regression. Results: All tumours expressed membranous Ecadherin both in keratinocytes, and in tumoural cells and no differences were noted among the histological groups analysed.However, the intensity of the E-cadherin immunolabeling decreased in the presence of lymphoid infiltration and varied significantly among the groups considered (p<0.0001).Conclusion: This study strongly suggests a down-regulation of E-cadherin expression in CCH pathogenesis and progression.The loss of E-cadherin expression might represent an activation/ maturation process of the tumoural cells constituting a switch for CCH regression2013-09-24T09:45:28Z2009-01-01T00:00:00Z2009info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10348/2747engPires, IsabelQueiroga, FelisbinaAlves, AnabelaSilva, FilipeLopes, Carlosinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-02T12:47:11Zoai:repositorio.utad.pt:10348/2747Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:04:22.881071Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Decrease of E-cadherin expression in canine cutaneous histiocytoma appears to be related to its spontaneous regression. |
title |
Decrease of E-cadherin expression in canine cutaneous histiocytoma appears to be related to its spontaneous regression. |
spellingShingle |
Decrease of E-cadherin expression in canine cutaneous histiocytoma appears to be related to its spontaneous regression. Pires, Isabel Canine cutaneous histiocytoma E-cadherin immunohistochemistry tumour regression |
title_short |
Decrease of E-cadherin expression in canine cutaneous histiocytoma appears to be related to its spontaneous regression. |
title_full |
Decrease of E-cadherin expression in canine cutaneous histiocytoma appears to be related to its spontaneous regression. |
title_fullStr |
Decrease of E-cadherin expression in canine cutaneous histiocytoma appears to be related to its spontaneous regression. |
title_full_unstemmed |
Decrease of E-cadherin expression in canine cutaneous histiocytoma appears to be related to its spontaneous regression. |
title_sort |
Decrease of E-cadherin expression in canine cutaneous histiocytoma appears to be related to its spontaneous regression. |
author |
Pires, Isabel |
author_facet |
Pires, Isabel Queiroga, Felisbina Alves, Anabela Silva, Filipe Lopes, Carlos |
author_role |
author |
author2 |
Queiroga, Felisbina Alves, Anabela Silva, Filipe Lopes, Carlos |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Pires, Isabel Queiroga, Felisbina Alves, Anabela Silva, Filipe Lopes, Carlos |
dc.subject.por.fl_str_mv |
Canine cutaneous histiocytoma E-cadherin immunohistochemistry tumour regression |
topic |
Canine cutaneous histiocytoma E-cadherin immunohistochemistry tumour regression |
description |
Background: Canine cutaneous histiocytoma (CCH) is an epidermotropic tumour of Langerhans cells, most frequent in young dogs, which undergoes spontaneous regression. Materials and Methods: E-cadherin immunoexpression was analysed in ninety-three CCH, categorized according to Cockerell and Slauson (1976) criteria into four histological groups, representing different stages of tumour regression. Results: All tumours expressed membranous Ecadherin both in keratinocytes, and in tumoural cells and no differences were noted among the histological groups analysed.However, the intensity of the E-cadherin immunolabeling decreased in the presence of lymphoid infiltration and varied significantly among the groups considered (p<0.0001).Conclusion: This study strongly suggests a down-regulation of E-cadherin expression in CCH pathogenesis and progression.The loss of E-cadherin expression might represent an activation/ maturation process of the tumoural cells constituting a switch for CCH regression |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-01-01T00:00:00Z 2009 2013-09-24T09:45:28Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10348/2747 |
url |
http://hdl.handle.net/10348/2747 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799137129416097792 |