THE ROLE OF THE RED CELL DISTRIBUTION WIDTH IN CAROTID ARTERY DISEASE

Detalhes bibliográficos
Autor(a) principal: Duarte-Gamas, Luis
Data de Publicação: 2020
Outros Autores: Pereira-Neves, António, Fragão-Marques, Mariana, Vilaça, Isabel, Rocha-Neves, João P., Teixeira, José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.48750/acv.324
Resumo: Introduction: Carotid disease affects 3-4% of the general population. The association between systemic low-grade inflammation and atherosclerosis has led to the study of blood biomarkers, such as red blood cell distribution width – coefficient of variation (RDW-CV), and their role in the pathophysiology and prognosis of carotid artery disease. The aim of this study was to review the literature regarding the relevance of RDW-CV in carotid artery disease.  Methods: A Medline search was performed in order to identify publications focused on the physiopathology of RDW-CV and its impact in patients with carotid artery disease. Results: Increased RDW-CV was associated with increased carotid intima-media thickness (CIMT) in several studies. It was associated with plaque presence and progression. One study demonstrated an independent association between all-cause and cardiovascular-related mortality in patients with asymptomatic carotid artery stenosis and increased RDW-CV.  Conclusion: RDW-CV is a widely available, easy to measure, and low-cost marker that seems to be associated with subclinical carotid atherosclerosis. However, further studies are needed in order to determine its clinical relevance in this setting.
id RCAP_d043cc6ab33f096a580b268666e2d3fd
oai_identifier_str oai:ojs.acvjournal.com:article/324
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling THE ROLE OF THE RED CELL DISTRIBUTION WIDTH IN CAROTID ARTERY DISEASEA RELEVÂNCIA DO ÍNDICE DE ANISOCITOSE NA DOENÇA CAROTÍDEACarotid artery diseaseErythrocyte size determinationBiomarkersDoença arterial carotídeaDeterminação de tamanho eritrocitárioBiomarcadoresIntroduction: Carotid disease affects 3-4% of the general population. The association between systemic low-grade inflammation and atherosclerosis has led to the study of blood biomarkers, such as red blood cell distribution width – coefficient of variation (RDW-CV), and their role in the pathophysiology and prognosis of carotid artery disease. The aim of this study was to review the literature regarding the relevance of RDW-CV in carotid artery disease.  Methods: A Medline search was performed in order to identify publications focused on the physiopathology of RDW-CV and its impact in patients with carotid artery disease. Results: Increased RDW-CV was associated with increased carotid intima-media thickness (CIMT) in several studies. It was associated with plaque presence and progression. One study demonstrated an independent association between all-cause and cardiovascular-related mortality in patients with asymptomatic carotid artery stenosis and increased RDW-CV.  Conclusion: RDW-CV is a widely available, easy to measure, and low-cost marker that seems to be associated with subclinical carotid atherosclerosis. However, further studies are needed in order to determine its clinical relevance in this setting.Introdução: A doença carotídea afeta 3-4% da população geral. A associação entre inflamação sistémica de baixo grau e aterosclerose estimulou o estudo de biomarcadores sanguíneos, nomeadamente o índice de anisocitose (RDW-CV), e a sua importância na fisiopatologia e prognóstico da doença carotídea. O objetivo deste estudo foi elaborar uma revisão da literatura no que diz respeito à relevância do RDW-CV na doença carotídea.  Métodos: Foi realizada uma pesquisa na base Medline de forma a identificar publicações focadas na fisiopatologia do RDW-CV e o seu impacto na doença carotídea.  Resultados: Um aumento de RDW-CV associou-se a um espessamento íntima-média carotídea (CIMT) em vários estudos. Associou-se à presença de placas de aterosclerose e sua progressão. Um estudo demonstrou uma associação independente entre mortalidade por todas as causas e mortalidade cardiovascular com o aumento do RDW-CV em doentes com estenose carotídea assintomática.  Conclusão: O RDW-CV é um marcador de baixo custo, prontamente disponível e fácil de se obter que parece estar associado a aterosclerose carotídea subclínica. Contudo são necessários mais estudos para se determinar a sua importância clínica neste contexto. Sociedade Portuguesa de Angiologia e Cirurgia Vascular2020-12-13T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.48750/acv.324oai:ojs.acvjournal.com:article/324Angiologia e Cirurgia Vascular; Vol. 16 No. 3 (2020): September; 167-170Angiologia e Cirurgia Vascular; Vol. 16 N.º 3 (2020): Setembro; 167-1702183-00961646-706Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://acvjournal.com/index.php/acv/article/view/324https://doi.org/10.48750/acv.324http://acvjournal.com/index.php/acv/article/view/324/203Copyright (c) 2020 Angiologia e Cirurgia Vascularinfo:eu-repo/semantics/openAccessDuarte-Gamas, LuisPereira-Neves, AntónioFragão-Marques, MarianaVilaça, IsabelRocha-Neves, João P.Teixeira, José2022-05-23T15:10:10Zoai:ojs.acvjournal.com:article/324Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T14:57:41.263176Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv THE ROLE OF THE RED CELL DISTRIBUTION WIDTH IN CAROTID ARTERY DISEASE
A RELEVÂNCIA DO ÍNDICE DE ANISOCITOSE NA DOENÇA CAROTÍDEA
title THE ROLE OF THE RED CELL DISTRIBUTION WIDTH IN CAROTID ARTERY DISEASE
spellingShingle THE ROLE OF THE RED CELL DISTRIBUTION WIDTH IN CAROTID ARTERY DISEASE
Duarte-Gamas, Luis
Carotid artery disease
Erythrocyte size determination
Biomarkers
Doença arterial carotídea
Determinação de tamanho eritrocitário
Biomarcadores
title_short THE ROLE OF THE RED CELL DISTRIBUTION WIDTH IN CAROTID ARTERY DISEASE
title_full THE ROLE OF THE RED CELL DISTRIBUTION WIDTH IN CAROTID ARTERY DISEASE
title_fullStr THE ROLE OF THE RED CELL DISTRIBUTION WIDTH IN CAROTID ARTERY DISEASE
title_full_unstemmed THE ROLE OF THE RED CELL DISTRIBUTION WIDTH IN CAROTID ARTERY DISEASE
title_sort THE ROLE OF THE RED CELL DISTRIBUTION WIDTH IN CAROTID ARTERY DISEASE
author Duarte-Gamas, Luis
author_facet Duarte-Gamas, Luis
Pereira-Neves, António
Fragão-Marques, Mariana
Vilaça, Isabel
Rocha-Neves, João P.
Teixeira, José
author_role author
author2 Pereira-Neves, António
Fragão-Marques, Mariana
Vilaça, Isabel
Rocha-Neves, João P.
Teixeira, José
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Duarte-Gamas, Luis
Pereira-Neves, António
Fragão-Marques, Mariana
Vilaça, Isabel
Rocha-Neves, João P.
Teixeira, José
dc.subject.por.fl_str_mv Carotid artery disease
Erythrocyte size determination
Biomarkers
Doença arterial carotídea
Determinação de tamanho eritrocitário
Biomarcadores
topic Carotid artery disease
Erythrocyte size determination
Biomarkers
Doença arterial carotídea
Determinação de tamanho eritrocitário
Biomarcadores
description Introduction: Carotid disease affects 3-4% of the general population. The association between systemic low-grade inflammation and atherosclerosis has led to the study of blood biomarkers, such as red blood cell distribution width – coefficient of variation (RDW-CV), and their role in the pathophysiology and prognosis of carotid artery disease. The aim of this study was to review the literature regarding the relevance of RDW-CV in carotid artery disease.  Methods: A Medline search was performed in order to identify publications focused on the physiopathology of RDW-CV and its impact in patients with carotid artery disease. Results: Increased RDW-CV was associated with increased carotid intima-media thickness (CIMT) in several studies. It was associated with plaque presence and progression. One study demonstrated an independent association between all-cause and cardiovascular-related mortality in patients with asymptomatic carotid artery stenosis and increased RDW-CV.  Conclusion: RDW-CV is a widely available, easy to measure, and low-cost marker that seems to be associated with subclinical carotid atherosclerosis. However, further studies are needed in order to determine its clinical relevance in this setting.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-13T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.48750/acv.324
oai:ojs.acvjournal.com:article/324
url https://doi.org/10.48750/acv.324
identifier_str_mv oai:ojs.acvjournal.com:article/324
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://acvjournal.com/index.php/acv/article/view/324
https://doi.org/10.48750/acv.324
http://acvjournal.com/index.php/acv/article/view/324/203
dc.rights.driver.fl_str_mv Copyright (c) 2020 Angiologia e Cirurgia Vascular
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Angiologia e Cirurgia Vascular
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Angiologia e Cirurgia Vascular
publisher.none.fl_str_mv Sociedade Portuguesa de Angiologia e Cirurgia Vascular
dc.source.none.fl_str_mv Angiologia e Cirurgia Vascular; Vol. 16 No. 3 (2020): September; 167-170
Angiologia e Cirurgia Vascular; Vol. 16 N.º 3 (2020): Setembro; 167-170
2183-0096
1646-706X
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799129849831358464

Registros relacionados