Renal replacement therapies for metformin induced lactic acidosis

Detalhes bibliográficos
Autor(a) principal: Francisco Manuel Pires Maia Figueira de Lemos
Data de Publicação: 2020
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/128850
Resumo: Metformin is an oral hypoglicemic drug used as first line therapy in type 2 diabetes mellitus, a very common disease worldwide. It is well tolerated, safe and inexpensive, and it is not associated with some undesired adverse effects like weight gain or hypoglicemia. The most dangerous side effect associated with metformin use is lactic acidosis, a rare but life-threatening condition with a mortality rate up to 50%. Regarding treatment of metformin-associated lactic acidosis (MALA), initial approach consists on resuscitating the patient and assuring supportive measures. Then, extracorporeal treatments, such as renal replacement therapies (RRT), are considered very effective and their use is supported. However, renal replacement therapies have diferente modalities and choosing which modality to use, as well as its timing and duration, can be a very hard task as there are no irrefutable indications about this subject.
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spelling Renal replacement therapies for metformin induced lactic acidosisCiências médicas e da saúdeMedical and Health sciencesMetformin is an oral hypoglicemic drug used as first line therapy in type 2 diabetes mellitus, a very common disease worldwide. It is well tolerated, safe and inexpensive, and it is not associated with some undesired adverse effects like weight gain or hypoglicemia. The most dangerous side effect associated with metformin use is lactic acidosis, a rare but life-threatening condition with a mortality rate up to 50%. Regarding treatment of metformin-associated lactic acidosis (MALA), initial approach consists on resuscitating the patient and assuring supportive measures. Then, extracorporeal treatments, such as renal replacement therapies (RRT), are considered very effective and their use is supported. However, renal replacement therapies have diferente modalities and choosing which modality to use, as well as its timing and duration, can be a very hard task as there are no irrefutable indications about this subject.2020-05-192020-05-19T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttps://hdl.handle.net/10216/128850TID:202613534porFrancisco Manuel Pires Maia Figueira de Lemosinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T12:38:07Zoai:repositorio-aberto.up.pt:10216/128850Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:23:50.513955Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Renal replacement therapies for metformin induced lactic acidosis
title Renal replacement therapies for metformin induced lactic acidosis
spellingShingle Renal replacement therapies for metformin induced lactic acidosis
Francisco Manuel Pires Maia Figueira de Lemos
Ciências médicas e da saúde
Medical and Health sciences
title_short Renal replacement therapies for metformin induced lactic acidosis
title_full Renal replacement therapies for metformin induced lactic acidosis
title_fullStr Renal replacement therapies for metformin induced lactic acidosis
title_full_unstemmed Renal replacement therapies for metformin induced lactic acidosis
title_sort Renal replacement therapies for metformin induced lactic acidosis
author Francisco Manuel Pires Maia Figueira de Lemos
author_facet Francisco Manuel Pires Maia Figueira de Lemos
author_role author
dc.contributor.author.fl_str_mv Francisco Manuel Pires Maia Figueira de Lemos
dc.subject.por.fl_str_mv Ciências médicas e da saúde
Medical and Health sciences
topic Ciências médicas e da saúde
Medical and Health sciences
description Metformin is an oral hypoglicemic drug used as first line therapy in type 2 diabetes mellitus, a very common disease worldwide. It is well tolerated, safe and inexpensive, and it is not associated with some undesired adverse effects like weight gain or hypoglicemia. The most dangerous side effect associated with metformin use is lactic acidosis, a rare but life-threatening condition with a mortality rate up to 50%. Regarding treatment of metformin-associated lactic acidosis (MALA), initial approach consists on resuscitating the patient and assuring supportive measures. Then, extracorporeal treatments, such as renal replacement therapies (RRT), are considered very effective and their use is supported. However, renal replacement therapies have diferente modalities and choosing which modality to use, as well as its timing and duration, can be a very hard task as there are no irrefutable indications about this subject.
publishDate 2020
dc.date.none.fl_str_mv 2020-05-19
2020-05-19T00:00:00Z
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dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/128850
TID:202613534
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identifier_str_mv TID:202613534
dc.language.iso.fl_str_mv por
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