Changes in diadenosine polyphosphates during alignment-fit and orthokeratology rigid gas permeable lens wear

Detalhes bibliográficos
Autor(a) principal: Carracedo, Gonzalo
Data de Publicação: 2012
Outros Autores: González-Méijome, José Manuel, Pintor, Jésus
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/20720
Resumo: The authors thank Paragon Vision Science (Mesa, AZ), Lenticon SA (Madrid, Spain), and Interlenco SA (Madrid, Spain) for donating the lenses, and Bausch & Lomb (Rochester, NY) for donating the care solutions used in the study.
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spelling Changes in diadenosine polyphosphates during alignment-fit and orthokeratology rigid gas permeable lens wearDinocleotidesDry eyeOrthokeratologyAp4AScience & TechnologyThe authors thank Paragon Vision Science (Mesa, AZ), Lenticon SA (Madrid, Spain), and Interlenco SA (Madrid, Spain) for donating the lenses, and Bausch & Lomb (Rochester, NY) for donating the care solutions used in the study.PURPOSE: To evaluate the levels of dinucleotides diadenosine tetraphosphate (Ap(4)A) and diadenosine pentaphosphate (Ap(5)A) in tears of patients wearing rigid gas permeable (RGP) contact lenses on a daily wear basis and of patients wearing reverse-geometry RGP lenses overnight for orthokeratology treatment. METHODS: Twenty-two young volunteers (10 females, 12 males; 23.47 ± 4.49 years) were fitted with an alignment-fit RGP lens (paflufocon B) for a month, and after a 15-day washout period they were fitted with reverse-geometry RGP lenses for corneal reshaping (paflufocon D) for another month. During each period, tears were collected at baseline day 1, 7, 15, and 28. Ap(4)A and Ap(5)A were measured by high-pressure liquid chromatography (HPLC). Additionally, corneal staining, break-up time (BUT), Schirmer test, and dryness symptoms were evaluated. RESULTS: Ap(4)A concentrations increased significantly from baseline during the whole period of daily wear of RGP lenses (P < 0.001); concentration was also significantly higher than in the orthokeratology group, which remained at baseline levels during the study period except at day 1 (P < 0.001) and day 28 (P = 0.041). While BUT and Schirmer remained unchanged in both groups, discomfort and dryness were significantly increased during alignment-fit RGP daily wear but not during the orthokeratology period. CONCLUSIONS: Daily wear of RGP lenses increased the levels of Ap(4)A due to mechanical stimulation by blinking of the corneal epithelium, and this is associated with discomfort. Also, orthokeratology did not produce symptoms or signs of ocular dryness, which could be a potential advantage over soft contact lenses in terms of contact lens-induced dryness.Supported by Ministerio de Ciencia e Innovacion Grant SAF2010-16024, RETIC Red de Patologia ocular del envejecimiento, calidad visual, y calidad de vida Grant RD07/0062/0004, and BSCHUCM Grant GR58/08.Association for Research in Vision and Ophthalmology (ARVO)Universidade do MinhoCarracedo, GonzaloGonzález-Méijome, José ManuelPintor, Jésus20122012-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/20720engCarracedo G, González-Méijome JM, Pintor J. Changes in diadenosine polyphosphates during alignment-fit and orthokeratology rigid gas permeable lens wear. Invest Ophthalmol Vis Sci. 2012 Jul 3;53(8):4426-32. doi:10.1167/iovs.11-9342.0146-040410.1167/iovs.11-934222669724http://www.iovs.org/cgi/pmidlookup?view=long&pmid=22669724info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:32:05Zoai:repositorium.sdum.uminho.pt:1822/20720Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:27:26.970302Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Changes in diadenosine polyphosphates during alignment-fit and orthokeratology rigid gas permeable lens wear
title Changes in diadenosine polyphosphates during alignment-fit and orthokeratology rigid gas permeable lens wear
spellingShingle Changes in diadenosine polyphosphates during alignment-fit and orthokeratology rigid gas permeable lens wear
Carracedo, Gonzalo
Dinocleotides
Dry eye
Orthokeratology
Ap4A
Science & Technology
title_short Changes in diadenosine polyphosphates during alignment-fit and orthokeratology rigid gas permeable lens wear
title_full Changes in diadenosine polyphosphates during alignment-fit and orthokeratology rigid gas permeable lens wear
title_fullStr Changes in diadenosine polyphosphates during alignment-fit and orthokeratology rigid gas permeable lens wear
title_full_unstemmed Changes in diadenosine polyphosphates during alignment-fit and orthokeratology rigid gas permeable lens wear
title_sort Changes in diadenosine polyphosphates during alignment-fit and orthokeratology rigid gas permeable lens wear
author Carracedo, Gonzalo
author_facet Carracedo, Gonzalo
González-Méijome, José Manuel
Pintor, Jésus
author_role author
author2 González-Méijome, José Manuel
Pintor, Jésus
author2_role author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Carracedo, Gonzalo
González-Méijome, José Manuel
Pintor, Jésus
dc.subject.por.fl_str_mv Dinocleotides
Dry eye
Orthokeratology
Ap4A
Science & Technology
topic Dinocleotides
Dry eye
Orthokeratology
Ap4A
Science & Technology
description The authors thank Paragon Vision Science (Mesa, AZ), Lenticon SA (Madrid, Spain), and Interlenco SA (Madrid, Spain) for donating the lenses, and Bausch & Lomb (Rochester, NY) for donating the care solutions used in the study.
publishDate 2012
dc.date.none.fl_str_mv 2012
2012-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/20720
url http://hdl.handle.net/1822/20720
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Carracedo G, González-Méijome JM, Pintor J. Changes in diadenosine polyphosphates during alignment-fit and orthokeratology rigid gas permeable lens wear. Invest Ophthalmol Vis Sci. 2012 Jul 3;53(8):4426-32. doi:10.1167/iovs.11-9342.
0146-0404
10.1167/iovs.11-9342
22669724
http://www.iovs.org/cgi/pmidlookup?view=long&pmid=22669724
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Association for Research in Vision and Ophthalmology (ARVO)
publisher.none.fl_str_mv Association for Research in Vision and Ophthalmology (ARVO)
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799132765924360192

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