Nucleic acid oxidation in Alzheimer disease
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/4683 https://doi.org/10.1016/j.freeradbiomed.2008.01.002 |
Resumo: | Increasing evidence suggests that oxidative stress is intimately associated with Alzheimer disease pathophysiology. Nucleic acids (nuclear DNA, mitochondrial DNA, and RNA) are one of the several cellular macromolecules damaged by reactive oxygen species, particularly the hydroxyl radical. Because neurons are irreplaceable and survive as long as the organism does, they need elaborate defense mechanisms to ensure their longevity. In Alzheimer disease, however, an accumulation of nucleic acid oxidation is observed, indicating an increased level of oxidative stress and/or a decreased capacity to repair the nucleic acid damage. In this review, we present data supporting the notion that mitochondrial and metal abnormalities are key sources of oxidative stress in Alzheimer disease. Furthermore, we outline the mechanisms of nucleic acid oxidation and repair. Finally, evidence showing the occurrence of nucleic acid oxidation in Alzheimer disease will be discussed. |
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Nucleic acid oxidation in Alzheimer diseaseAlzheimer's diseaseDNA oxidationDNA repairOxidative stressRNA damageRNA repairFree radicalsIncreasing evidence suggests that oxidative stress is intimately associated with Alzheimer disease pathophysiology. Nucleic acids (nuclear DNA, mitochondrial DNA, and RNA) are one of the several cellular macromolecules damaged by reactive oxygen species, particularly the hydroxyl radical. Because neurons are irreplaceable and survive as long as the organism does, they need elaborate defense mechanisms to ensure their longevity. In Alzheimer disease, however, an accumulation of nucleic acid oxidation is observed, indicating an increased level of oxidative stress and/or a decreased capacity to repair the nucleic acid damage. In this review, we present data supporting the notion that mitochondrial and metal abnormalities are key sources of oxidative stress in Alzheimer disease. Furthermore, we outline the mechanisms of nucleic acid oxidation and repair. Finally, evidence showing the occurrence of nucleic acid oxidation in Alzheimer disease will be discussed.http://www.sciencedirect.com/science/article/B6T38-4RM7MWS-3/1/07d7e5640ecf31a878beade229f579502008info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleaplication/PDFhttp://hdl.handle.net/10316/4683http://hdl.handle.net/10316/4683https://doi.org/10.1016/j.freeradbiomed.2008.01.002engFree Radical Biology and Medicine. 44:8 (2008) 1493-1505Moreira, Paula I.Nunomura, AkihikoNakamura, MasaoTakeda, AtsushiShenk, Justin C.Aliev, GjumrakchSmith, Mark A.Perry, Georgeinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-02-26T11:01:38Zoai:estudogeral.uc.pt:10316/4683Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:43:29.923632Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Nucleic acid oxidation in Alzheimer disease |
title |
Nucleic acid oxidation in Alzheimer disease |
spellingShingle |
Nucleic acid oxidation in Alzheimer disease Moreira, Paula I. Alzheimer's disease DNA oxidation DNA repair Oxidative stress RNA damage RNA repair Free radicals |
title_short |
Nucleic acid oxidation in Alzheimer disease |
title_full |
Nucleic acid oxidation in Alzheimer disease |
title_fullStr |
Nucleic acid oxidation in Alzheimer disease |
title_full_unstemmed |
Nucleic acid oxidation in Alzheimer disease |
title_sort |
Nucleic acid oxidation in Alzheimer disease |
author |
Moreira, Paula I. |
author_facet |
Moreira, Paula I. Nunomura, Akihiko Nakamura, Masao Takeda, Atsushi Shenk, Justin C. Aliev, Gjumrakch Smith, Mark A. Perry, George |
author_role |
author |
author2 |
Nunomura, Akihiko Nakamura, Masao Takeda, Atsushi Shenk, Justin C. Aliev, Gjumrakch Smith, Mark A. Perry, George |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Moreira, Paula I. Nunomura, Akihiko Nakamura, Masao Takeda, Atsushi Shenk, Justin C. Aliev, Gjumrakch Smith, Mark A. Perry, George |
dc.subject.por.fl_str_mv |
Alzheimer's disease DNA oxidation DNA repair Oxidative stress RNA damage RNA repair Free radicals |
topic |
Alzheimer's disease DNA oxidation DNA repair Oxidative stress RNA damage RNA repair Free radicals |
description |
Increasing evidence suggests that oxidative stress is intimately associated with Alzheimer disease pathophysiology. Nucleic acids (nuclear DNA, mitochondrial DNA, and RNA) are one of the several cellular macromolecules damaged by reactive oxygen species, particularly the hydroxyl radical. Because neurons are irreplaceable and survive as long as the organism does, they need elaborate defense mechanisms to ensure their longevity. In Alzheimer disease, however, an accumulation of nucleic acid oxidation is observed, indicating an increased level of oxidative stress and/or a decreased capacity to repair the nucleic acid damage. In this review, we present data supporting the notion that mitochondrial and metal abnormalities are key sources of oxidative stress in Alzheimer disease. Furthermore, we outline the mechanisms of nucleic acid oxidation and repair. Finally, evidence showing the occurrence of nucleic acid oxidation in Alzheimer disease will be discussed. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/4683 http://hdl.handle.net/10316/4683 https://doi.org/10.1016/j.freeradbiomed.2008.01.002 |
url |
http://hdl.handle.net/10316/4683 https://doi.org/10.1016/j.freeradbiomed.2008.01.002 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Free Radical Biology and Medicine. 44:8 (2008) 1493-1505 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
aplication/PDF |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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