Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells

Detalhes bibliográficos
Autor(a) principal: Teixeira, Ricardo G.
Data de Publicação: 2018
Outros Autores: Brás, Ana Rita, Côrte-Real, Leonor, Tatikonda, Rajendhraprasad, Sanches, Anabela, Robalo, Maria Paula, Avecilla, Fernando, Moreira, Tiago, Garcia, M. Helena, Haukka, Matti, Preto, Ana, Valente, Andreia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.21/9156
Resumo: Three new compounds have been synthesized and completely characterized by analytical and spectroscopic techniques. The new bipyridine-perfluorinated ligand L1 and the new organometallic complex [Ru(eta(5)-MeCp)(PPh3)(2)Cl] (Ru1) crystalize in the centrosymmetric triclinic space group P (1) over bar. Analysis of the phenotypic effects induced by both organometallic complexes Ru1 and [Ru(eta(5)-MeCp)(PPh3)(L1)] [CF3SO3] (Ru2), on human colorectal cancer cells (SW480 and RKO) survival, showed that Ru2 has a potent anti-proliferative activity, 4-6 times higher than cisplatin, and induce apoptosis in these cells. Data obtained in a noncancerous cell line derived from normal colon epithelial cells (NCM460) revealed an intrinsic selectivity of Ru2 for malignant cells at low concentrations, showing the high potential of this compound as a selective anticancer agent. (C) 2017 Elsevier Masson SAS. All rights reserved.
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spelling Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cellsRuthenium methylcyclopentadienylColorectal cancerApoptosisCompostos organometálicosApoptoseCancro colo-retalThree new compounds have been synthesized and completely characterized by analytical and spectroscopic techniques. The new bipyridine-perfluorinated ligand L1 and the new organometallic complex [Ru(eta(5)-MeCp)(PPh3)(2)Cl] (Ru1) crystalize in the centrosymmetric triclinic space group P (1) over bar. Analysis of the phenotypic effects induced by both organometallic complexes Ru1 and [Ru(eta(5)-MeCp)(PPh3)(L1)] [CF3SO3] (Ru2), on human colorectal cancer cells (SW480 and RKO) survival, showed that Ru2 has a potent anti-proliferative activity, 4-6 times higher than cisplatin, and induce apoptosis in these cells. Data obtained in a noncancerous cell line derived from normal colon epithelial cells (NCM460) revealed an intrinsic selectivity of Ru2 for malignant cells at low concentrations, showing the high potential of this compound as a selective anticancer agent. (C) 2017 Elsevier Masson SAS. All rights reserved.ElsevierRCIPLTeixeira, Ricardo G.Brás, Ana RitaCôrte-Real, LeonorTatikonda, RajendhraprasadSanches, AnabelaRobalo, Maria PaulaAvecilla, FernandoMoreira, TiagoGarcia, M. HelenaHaukka, MattiPreto, AnaValente, Andreia2018-12-11T10:47:15Z2018-01-012018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/9156engTEIXEIRA, Ricardo G.; [et al] – Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells. European Journal of Medicinal Chemistry. ISSN 0223-5234. Vol. 143, (2018), pp. 503-5140223-523410.1016/j.ejmech.2017.11.059metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T09:57:31Zoai:repositorio.ipl.pt:10400.21/9156Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:17:47.360979Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells
title Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells
spellingShingle Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells
Teixeira, Ricardo G.
Ruthenium methylcyclopentadienyl
Colorectal cancer
Apoptosis
Compostos organometálicos
Apoptose
Cancro colo-retal
title_short Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells
title_full Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells
title_fullStr Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells
title_full_unstemmed Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells
title_sort Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells
author Teixeira, Ricardo G.
author_facet Teixeira, Ricardo G.
Brás, Ana Rita
Côrte-Real, Leonor
Tatikonda, Rajendhraprasad
Sanches, Anabela
Robalo, Maria Paula
Avecilla, Fernando
Moreira, Tiago
Garcia, M. Helena
Haukka, Matti
Preto, Ana
Valente, Andreia
author_role author
author2 Brás, Ana Rita
Côrte-Real, Leonor
Tatikonda, Rajendhraprasad
Sanches, Anabela
Robalo, Maria Paula
Avecilla, Fernando
Moreira, Tiago
Garcia, M. Helena
Haukka, Matti
Preto, Ana
Valente, Andreia
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv RCIPL
dc.contributor.author.fl_str_mv Teixeira, Ricardo G.
Brás, Ana Rita
Côrte-Real, Leonor
Tatikonda, Rajendhraprasad
Sanches, Anabela
Robalo, Maria Paula
Avecilla, Fernando
Moreira, Tiago
Garcia, M. Helena
Haukka, Matti
Preto, Ana
Valente, Andreia
dc.subject.por.fl_str_mv Ruthenium methylcyclopentadienyl
Colorectal cancer
Apoptosis
Compostos organometálicos
Apoptose
Cancro colo-retal
topic Ruthenium methylcyclopentadienyl
Colorectal cancer
Apoptosis
Compostos organometálicos
Apoptose
Cancro colo-retal
description Three new compounds have been synthesized and completely characterized by analytical and spectroscopic techniques. The new bipyridine-perfluorinated ligand L1 and the new organometallic complex [Ru(eta(5)-MeCp)(PPh3)(2)Cl] (Ru1) crystalize in the centrosymmetric triclinic space group P (1) over bar. Analysis of the phenotypic effects induced by both organometallic complexes Ru1 and [Ru(eta(5)-MeCp)(PPh3)(L1)] [CF3SO3] (Ru2), on human colorectal cancer cells (SW480 and RKO) survival, showed that Ru2 has a potent anti-proliferative activity, 4-6 times higher than cisplatin, and induce apoptosis in these cells. Data obtained in a noncancerous cell line derived from normal colon epithelial cells (NCM460) revealed an intrinsic selectivity of Ru2 for malignant cells at low concentrations, showing the high potential of this compound as a selective anticancer agent. (C) 2017 Elsevier Masson SAS. All rights reserved.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-11T10:47:15Z
2018-01-01
2018-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.21/9156
url http://hdl.handle.net/10400.21/9156
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv TEIXEIRA, Ricardo G.; [et al] – Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells. European Journal of Medicinal Chemistry. ISSN 0223-5234. Vol. 143, (2018), pp. 503-514
0223-5234
10.1016/j.ejmech.2017.11.059
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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