Human CD8+ T Cells in Asthma: Possible Pathways and Roles for NK-Like Subtypes

Detalhes bibliográficos
Autor(a) principal: Lourenço, Olga
Data de Publicação: 2016
Outros Autores: Fonseca, A M, Barata, Luis Taborda
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.6/9355
Resumo: Asthma affects approximately 300 million people worldwide and is the most common chronic lung disease, which usually is associated with bronchial inflammation. Most research has focused upon the role of CD4+ T cells, and relatively few studies have addressed the phenotypic and functional roles of CD8+ T cell types and subtypes. Human NK-like CD8+ T cells may involve cells that have been described as CD8+CD28-, CD8+CD28-CD57+, CD8+CD27-, or CD8+ effector memory (TEM) cells, among other. However, most of the data that are available regarding these various cell types were obtained in murine models did not thoroughly characterize these cells with phenotypically or functionally or did not involve asthma-related settings. Nevertheless, one may conceptualize three principal roles for human NK-like CD8+ T cells in asthma: disease-promoting, regulatory, and/or tissue repair. Although evidence for some of these roles is scarce, it is possible to extrapolate some data from overlapping or related CD8+ T cell phenotypes, with caution. Clearly, further research is warranted, namely in terms of thorough functional and phenotypic characterization of human NK-like CD8+ T cells in human asthma of varying severity.
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spelling Human CD8+ T Cells in Asthma: Possible Pathways and Roles for NK-Like SubtypesAsthmaCells - CD8Cells - CD28Cells - CD27Cells - CD57HumanNK-likeT cellsAsthma affects approximately 300 million people worldwide and is the most common chronic lung disease, which usually is associated with bronchial inflammation. Most research has focused upon the role of CD4+ T cells, and relatively few studies have addressed the phenotypic and functional roles of CD8+ T cell types and subtypes. Human NK-like CD8+ T cells may involve cells that have been described as CD8+CD28-, CD8+CD28-CD57+, CD8+CD27-, or CD8+ effector memory (TEM) cells, among other. However, most of the data that are available regarding these various cell types were obtained in murine models did not thoroughly characterize these cells with phenotypically or functionally or did not involve asthma-related settings. Nevertheless, one may conceptualize three principal roles for human NK-like CD8+ T cells in asthma: disease-promoting, regulatory, and/or tissue repair. Although evidence for some of these roles is scarce, it is possible to extrapolate some data from overlapping or related CD8+ T cell phenotypes, with caution. Clearly, further research is warranted, namely in terms of thorough functional and phenotypic characterization of human NK-like CD8+ T cells in human asthma of varying severity.uBibliorumLourenço, OlgaFonseca, A MBarata, Luis Taborda2020-02-19T09:42:06Z20162016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/9355eng10.3389/fimmu.2016.00638info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-15T09:50:20Zoai:ubibliorum.ubi.pt:10400.6/9355Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:49:29.417284Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Human CD8+ T Cells in Asthma: Possible Pathways and Roles for NK-Like Subtypes
title Human CD8+ T Cells in Asthma: Possible Pathways and Roles for NK-Like Subtypes
spellingShingle Human CD8+ T Cells in Asthma: Possible Pathways and Roles for NK-Like Subtypes
Lourenço, Olga
Asthma
Cells - CD8
Cells - CD28
Cells - CD27
Cells - CD57
Human
NK-like
T cells
title_short Human CD8+ T Cells in Asthma: Possible Pathways and Roles for NK-Like Subtypes
title_full Human CD8+ T Cells in Asthma: Possible Pathways and Roles for NK-Like Subtypes
title_fullStr Human CD8+ T Cells in Asthma: Possible Pathways and Roles for NK-Like Subtypes
title_full_unstemmed Human CD8+ T Cells in Asthma: Possible Pathways and Roles for NK-Like Subtypes
title_sort Human CD8+ T Cells in Asthma: Possible Pathways and Roles for NK-Like Subtypes
author Lourenço, Olga
author_facet Lourenço, Olga
Fonseca, A M
Barata, Luis Taborda
author_role author
author2 Fonseca, A M
Barata, Luis Taborda
author2_role author
author
dc.contributor.none.fl_str_mv uBibliorum
dc.contributor.author.fl_str_mv Lourenço, Olga
Fonseca, A M
Barata, Luis Taborda
dc.subject.por.fl_str_mv Asthma
Cells - CD8
Cells - CD28
Cells - CD27
Cells - CD57
Human
NK-like
T cells
topic Asthma
Cells - CD8
Cells - CD28
Cells - CD27
Cells - CD57
Human
NK-like
T cells
description Asthma affects approximately 300 million people worldwide and is the most common chronic lung disease, which usually is associated with bronchial inflammation. Most research has focused upon the role of CD4+ T cells, and relatively few studies have addressed the phenotypic and functional roles of CD8+ T cell types and subtypes. Human NK-like CD8+ T cells may involve cells that have been described as CD8+CD28-, CD8+CD28-CD57+, CD8+CD27-, or CD8+ effector memory (TEM) cells, among other. However, most of the data that are available regarding these various cell types were obtained in murine models did not thoroughly characterize these cells with phenotypically or functionally or did not involve asthma-related settings. Nevertheless, one may conceptualize three principal roles for human NK-like CD8+ T cells in asthma: disease-promoting, regulatory, and/or tissue repair. Although evidence for some of these roles is scarce, it is possible to extrapolate some data from overlapping or related CD8+ T cell phenotypes, with caution. Clearly, further research is warranted, namely in terms of thorough functional and phenotypic characterization of human NK-like CD8+ T cells in human asthma of varying severity.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-01-01T00:00:00Z
2020-02-19T09:42:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.6/9355
url http://hdl.handle.net/10400.6/9355
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.3389/fimmu.2016.00638
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dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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