Schistosoma haematobium and bladder cancer: what lies beneath?
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.18/198 |
Resumo: | Schistosoma haematobium is a parasitic flatworm that infects millions of people, mostly in the developing world, and is associated with high incidence of bladder cancer although why is not clear. But our group was able to define the mechanistic relationship for the first time between infection of S. haematobium and cancer. We used in vitro models to demonstrate the presence of informative carcinogenesis-associated phenotypes in CHO cells exposed to Sh total antigen, in which we showed increased cell proliferation, decreased apoptosis, up regulation of the anti-apoptotic molecule Bcl-2, down regulation of the tumor suppressor protein p27, and increased cell migration and invasion. We further discuss the molecular and cellular events that might be responsible for schistosomiasis-related bladder cancer. |
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Schistosoma haematobium and bladder cancer: what lies beneath?Schistosoma haematobiumSquamous cell carcinoma of the bladderCHO cellsCarcinogenesis-associatedAnimal modelsKras mutationsEstrogenic DNA adductsInfecções Sistémicas e ZoonosesSchistosoma haematobium is a parasitic flatworm that infects millions of people, mostly in the developing world, and is associated with high incidence of bladder cancer although why is not clear. But our group was able to define the mechanistic relationship for the first time between infection of S. haematobium and cancer. We used in vitro models to demonstrate the presence of informative carcinogenesis-associated phenotypes in CHO cells exposed to Sh total antigen, in which we showed increased cell proliferation, decreased apoptosis, up regulation of the anti-apoptotic molecule Bcl-2, down regulation of the tumor suppressor protein p27, and increased cell migration and invasion. We further discuss the molecular and cellular events that might be responsible for schistosomiasis-related bladder cancer.Landes BioscienceRepositório Científico do Instituto Nacional de SaúdeBotelho, Mónica CatarinaMachado, José CarlosCosta, José Manuel Correia da2011-09-19T12:20:55Z2010-032010-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/198engVirulence. 2010 Mar-Apr;1(2):84-72150-5594info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:38:03Zoai:repositorio.insa.pt:10400.18/198Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:35:24.904484Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Schistosoma haematobium and bladder cancer: what lies beneath? |
title |
Schistosoma haematobium and bladder cancer: what lies beneath? |
spellingShingle |
Schistosoma haematobium and bladder cancer: what lies beneath? Botelho, Mónica Catarina Schistosoma haematobium Squamous cell carcinoma of the bladder CHO cells Carcinogenesis-associated Animal models Kras mutations Estrogenic DNA adducts Infecções Sistémicas e Zoonoses |
title_short |
Schistosoma haematobium and bladder cancer: what lies beneath? |
title_full |
Schistosoma haematobium and bladder cancer: what lies beneath? |
title_fullStr |
Schistosoma haematobium and bladder cancer: what lies beneath? |
title_full_unstemmed |
Schistosoma haematobium and bladder cancer: what lies beneath? |
title_sort |
Schistosoma haematobium and bladder cancer: what lies beneath? |
author |
Botelho, Mónica Catarina |
author_facet |
Botelho, Mónica Catarina Machado, José Carlos Costa, José Manuel Correia da |
author_role |
author |
author2 |
Machado, José Carlos Costa, José Manuel Correia da |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Botelho, Mónica Catarina Machado, José Carlos Costa, José Manuel Correia da |
dc.subject.por.fl_str_mv |
Schistosoma haematobium Squamous cell carcinoma of the bladder CHO cells Carcinogenesis-associated Animal models Kras mutations Estrogenic DNA adducts Infecções Sistémicas e Zoonoses |
topic |
Schistosoma haematobium Squamous cell carcinoma of the bladder CHO cells Carcinogenesis-associated Animal models Kras mutations Estrogenic DNA adducts Infecções Sistémicas e Zoonoses |
description |
Schistosoma haematobium is a parasitic flatworm that infects millions of people, mostly in the developing world, and is associated with high incidence of bladder cancer although why is not clear. But our group was able to define the mechanistic relationship for the first time between infection of S. haematobium and cancer. We used in vitro models to demonstrate the presence of informative carcinogenesis-associated phenotypes in CHO cells exposed to Sh total antigen, in which we showed increased cell proliferation, decreased apoptosis, up regulation of the anti-apoptotic molecule Bcl-2, down regulation of the tumor suppressor protein p27, and increased cell migration and invasion. We further discuss the molecular and cellular events that might be responsible for schistosomiasis-related bladder cancer. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-03 2010-03-01T00:00:00Z 2011-09-19T12:20:55Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/198 |
url |
http://hdl.handle.net/10400.18/198 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Virulence. 2010 Mar-Apr;1(2):84-7 2150-5594 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Landes Bioscience |
publisher.none.fl_str_mv |
Landes Bioscience |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132080210182144 |